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"model", "text": "CUP used the observed estimate; EPIC also prints the measurement-error-calibrated estimate 1.49 (0.91–2.43) per 100 g", "page": "SLR 2016 T79; Norat 2005 Table 4", "alternative": [1.49, 0.91, 2.43], "alt_note": "calibrated estimate, Table 4", "outcome": "colorectal"}, {"study": "english2004", "class": "model", "text": "CUP used the model not adjusted for processed meat; the paper also gives the mutually adjusted estimate (1.12 per 100 g after ×5.83)", "page": "SLR 2016 T79; English 2004 text/Table 3", "alternative": [1.1225, 0.8888, 1.5666], "alt_note": "model adjusted for processed meat, per serving/week × 5.83", "outcome": "colorectal"}, {"study": "english2004", "class": "cases", "text": "452 tumours entered as cases; 451 persons; contrast '<3' not '≤3'", "page": "SLR 2016 T79; English 2004 Table 1", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "jarvinen2001", "class": "exposure", "text": "Järvinen's row is labelled 'Red meat' (Table 3), but its quartile cut-points are 91–94 % of those for 'Meat, all', i.e. near-total meat; SLR 2010 itself flagged Järvinen, Lee and Nöthlings as undefined and ran without them (1.21, 1.06–1.37, p156)", "page": "SLR 2016 T79; Järvinen 2001 Table 2", "alternative": "remove", "alt_note": "no red-meat row in the paper", "outcome": "colorectal"}, {"study": "jarvinen2001", "class": "cases", "text": "CUP's colorectal case count includes the 63 colon cases twice in its total", "page": "SLR 2016 T79", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "lee2009", "class": "transcription", "text": "2010 extraction 0.80 (0.52–1.23); 2016 re-extraction 0.81 (0.50–1.29) from the same table", "page": "SLR 2010 Fig 70; SLR 2016 Fig 125", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "takachi2011", "class": "dose", "text": "CUP's men's doses (20–117 g) are the medians for total meat; red meat medians are 15–102 g (Table 2)", "page": "SLR 2016 T79; Takachi 2011 Table 2", "alternative": [1.394970580080643, 1.0751170832467631, 1.8099823262169192], "alt_note": "GL with the paper's red-meat medians, men+women fixed", "outcome": "colon"}, {"study": "takachi2011", "class": "exposure", "text": "JPHC 'red meat' includes ham, sausage and bacon; no unprocessed row in the paper", "page": "Takachi 2011 Methods", "alternative": null, "alt_note": "", "outcome": "colon"}, {"study": "takachi2011", "class": "cases", "text": "men's colon cases 481, CUP entered 259", "page": "SLR 2016 T79; Takachi 2011 Table 2", "alternative": null, "alt_note": "", "outcome": "colon"}, {"study": "larsson2005_distal", "class": "duplicate", "text": "SMC entered twice (distal and proximal colon as separate rows); one cohort, one row", "page": "SLR 2016 Fig 128", "alternative": [1.6851769595085448, 1.1108464998521765, 2.556448064819367], "alt_note": "distal + proximal combined (fixed) as one SMC row", "outcome": "colon"}, {"study": "larsson2005_proximal", "class": "duplicate", "text": "see distal row", "page": "SLR 2016 Fig 128", "alternative": "remove", "alt_note": "", "outcome": "colon"}, {"study": "jarvinen2001", "class": "exposure", "text": "near-total meat (see CRC)", "page": "Järvinen 2001 Table 3", "alternative": "remove", "alt_note": "no red-meat row", "outcome": "colon"}, {"study": "norat2005", "class": "model", "text": "observed estimate used; calibrated colon estimate 1.36 (0.74–2.50) printed", "page": "Norat 2005 Table 4", "alternative": [1.36, 0.74, 2.5], "alt_note": "calibrated", "outcome": "colon"}, {"study": "english2004", "class": "model", "text": "model not adjusted for processed meat", "page": "English 2004", "alternative": [1.0, 0.697, 1.4048], "alt_note": "adjusted for processed meat", "outcome": "colon"}, {"study": "wei2004", "class": "exposure", "text": "'red meat as main dish' excludes hamburger and mixed dishes; NHS and HPFS combined by CUP", "page": "Wei 2004 Table II", "alternative": null, "alt_note": "", "outcome": "colon"}, {"study": "bostick1994", "class": "exposure", "text": "'red meat main dish' includes ham", "page": "Bostick 1994 Table 3", "alternative": null, "alt_note": "", "outcome": "colon"}, {"study": "jarvinen2001", "class": "exposure", "text": "near-total meat", "page": "Järvinen 2001", "alternative": "remove", "alt_note": "", "outcome": "rectum"}, {"study": "takachi2011", "class": "dose", "text": "men's doses are total-meat medians", "page": "Takachi 2011 Table 2", "alternative": [0.9548993969806616, 0.6324995505698258, 1.4416340020045089], "alt_note": "paper's red-meat medians", "outcome": "rectum"}, {"study": "norat2005", "class": "model", "text": "observed estimate used; calibrated rectum estimate 1.75 (0.93–3.30) printed", "page": "Norat 2005 Table 4", "alternative": [1.75, 0.93, 3.3], "alt_note": "calibrated", "outcome": "rectum"}, {"study": "english2004", "class": "model", "text": "model not adjusted for processed meat (adjusted gives 1.48)", "page": "English 2004", "alternative": 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(w 2.13 %)"}, {"label": "lee2009", "cohort": "lee2009", "rr": 0.85, "lo": 0.45, "hi": 1.61, "w": 4.9063442337882615, "note": "SLR 2010 Fig 74 p170: per 100 g/day (categories: >=67 vs <24 g/day) (w 4.94 %)"}], "loo": {}, "reproduced": true}, {"name": "Colon – Chan 2011 Fig 4 (SLR's 9 + Larsson 2005 colon)", "k": 10, "re": [1.1685746328488957, 1.022344867109432, 1.3357201825631715], "fe": [1.1685746328488957, 1.022344867109432, 1.3357201825631715], "I2": 0.0, "Q": 6.926815643864484, "tau2": 0.0, "published": [1.17, 1.02, 1.33], "comment": "", "rows": [{"label": "bostick1994", "cohort": "bostick1994", "rr": 0.94, "lo": 0.43, "hi": 2.04, "w": 2.9491607655269942, "note": "SLR 2010 Fig 74 p170; T37 p165: per 100 g/day (categories: >3 vs <1 servings/week (beef, pork or lamb)) (w 3.29 %)"}, {"label": "singh1998", "cohort": "singh1998", "rr": 2.49, "lo": 0.46, "hi": 13.39, "w": 0.6290772060122294, "note": "SLR 2010 Fig 74 p170; T37 p164: per 100 g/day (categories: >=1 time/week vs never) (w 0.70 %)"}, {"label": "jarvinen2001", "cohort": "jarvinen2001", "rr": 1.3, "lo": 0.77, "hi": 2.17, "w": 6.65938910475511, "note": "SLR 2010 Fig 74 p170: per 100 g/day (categories: Q4 vs Q1) (w 7.47 %)"}, {"label": "english2004", "cohort": "english2004", "rr": 1.0, "lo": 0.69, "hi": 1.46, "w": 12.725872409711133, "note": "SLR 2010 Fig 74 p170: times/week converted (w 13.95 %)"}, {"label": "wei2004_(T37)", "cohort": "wei2004", "rr": 1.07, "lo": 0.74, "hi": 1.52, "w": 8.465323753626866, "note": "SLR 2010 Fig 74 p170; T37 p161: per 100 g/day (categories: >=5 servings/week vs 0-3/month) (w 15.55 %)"}, {"label": "wei2004_(T37)", "cohort": "wei2004", "rr": 1.19, "lo": 0.75, "hi": 1.88, "w": 8.465323753626866, "note": "SLR 2010 Fig 74 p170; T37 p162: per 100 g/day (categories: >=5 servings/week vs 0-3/month) (w 9.45 %)"}, {"label": "norat2005", "cohort": "norat2005", "rr": 1.2, "lo": 0.96, "hi": 1.48, "w": 38.15292799558391, "note": "SLR 2010 Fig 74 p170: per 100 g/day observed (w 42.51 %)"}, {"label": "oba2006", "cohort": "oba2006", "rr": 0.74, "lo": 0.28, "hi": 1.96, "w": 1.88792791669058, "note": "SLR 2010 Fig 74 p170: per 100 g/day (categories: M 56.6 vs 18.7; W 42.3 vs 10.7 g/day) (w 2.13 %)"}, {"label": "lee2009", "cohort": "lee2009", "rr": 0.85, "lo": 0.45, "hi": 1.61, "w": 4.399329283902239, "note": "SLR 2010 Fig 74 p170: per 100 g/day (categories: >=67 vs <24 g/day) (w 4.94 %)"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.68, "lo": 1.11, "hi": 2.55, "w": 10.333864191476614, "note": "Chan 2011 Fig 4: Larsson 2005 colon 1.68 (1.11–2.55), w 10.33 %; not in SLR Fig 74 and contradicts Chan S2"}], "loo": {}, "reproduced": true}, {"name": "Rectum – SLR 2010 Fig 78 (7 rows)", "k": 7, "re": [1.1832026615106503, 0.9814772029762794, 1.4263892568880394], "fe": [1.1832026615106503, 0.9814772029762794, 1.4263892568880394], "I2": 0.0, "Q": 4.094455811208733, "tau2": 0.0, "published": [1.18, 0.98, 1.42], "comment": "", "rows": [{"label": "jarvinen2001", "cohort": "jarvinen2001", "rr": 1.32, "lo": 0.69, "hi": 2.53, "w": 8.278857732251788, "note": "SLR 2010 Fig 78: per 100 g/day (categories: Q4 vs Q1) (w 8.24 %)"}, {"label": "english2004", "cohort": "english2004", "rr": 1.57, "lo": 0.99, "hi": 2.49, "w": 16.428669111106338, "note": "SLR 2010 Fig 78: times/week converted (w 16.35 %)"}, {"label": "wei2004_dered)", "cohort": "wei2004", "rr": 0.95, "lo": 0.47, "hi": 1.89, "w": 4.795920922538436, "note": "SLR 2010 Fig 78: per 100 g/day (categories: >=5 servings/week vs 0-3/month) (w 7.30 %)"}, {"label": "wei2004_dered)", "cohort": "wei2004", "rr": 0.91, "lo": 0.39, "hi": 2.15, "w": 4.795920922538436, "note": "SLR 2010 Fig 78: per 100 g/day (categories: >=5 servings/week vs 0-3/month) (w 4.72 %)"}, {"label": "norat2005", "cohort": "norat2005", "rr": 1.23, "lo": 0.94, "hi": 1.62, "w": 47.17357329291262, "note": "SLR 2010 Fig 78: per 100 g/day observed (w 47.17 %)"}, {"label": "lee2009", "cohort": "lee2009", "rr": 0.74, "lo": 0.33, "hi": 1.66, "w": 5.355186839452104, "note": "SLR 2010 Fig 78: per 100 g/day (categories: >=67 vs <24 g/day) (w 5.34 %)"}, {"label": "larsson2005", "cohort": "larsson2005", "rr": 0.98, "lo": 0.55, "hi": 1.72, "w": 10.75091271437519, "note": "SLR 2010 Fig 78: servings/week converted (w 10.87 %)"}], "loo": {}, "reproduced": true}, {"name": "CRC – highest vs lowest (SLR 2010 Fig 73, 12 rows)", "k": 12, "re": [1.1030762856870238, 1.0034151567948464, 1.212635950140284], "fe": [1.1041169448992636, 1.0217824830811277, 1.1930858555508153], "I2": 22.440504696289967, "Q": 14.182660623210397, "tau2": 0.005876373046786333, "published": [1.1, 1.0, 1.21], "comment": "", "rows": [{"label": "cross2010", "cohort": "cross2010", "rr": 1.13, "lo": 0.98, "hi": 1.3, "w": 21.081223093601814, "note": "SLR 2010 Fig 73: Q5 vs Q1 (w  %)"}, {"label": "lee2009", "cohort": "lee2009", "rr": 0.8, "lo": 0.6, "hi": 1.1, "w": 7.836529664666337, "note": "SLR 2010 Fig 73: >=67 vs <24 g/day (w  %)"}, {"label": "nothlings2009", "cohort": "nothlings2009", "rr": 0.96, "lo": 0.74, "hi": 1.23, "w": 10.292534453489298, "note": "SLR 2010 Fig 73: 26 vs 0-10.3 g/1000kcal/day (w  %)"}, {"label": "butler2008", "cohort": "butler2008", "rr": 1.01, "lo": 0.82, "hi": 1.26, "w": 13.051289129711813, "note": "SLR 2010 Fig 73: Q4 vs Q1 (w  %)"}, {"label": "chan2005", "cohort": "chan2005", "rr": 1.21, "lo": 0.85, "hi": 1.72, "w": 6.1092696724776125, "note": "SLR 2010 Fig 73: >0.5 vs <=0.5 servings/day (w  %)"}, {"label": "larsson2005", "cohort": "larsson2005", "rr": 1.22, "lo": 0.98, "hi": 1.53, "w": 12.422099352642883, "note": "SLR 2010 Fig 73: >=4 vs <2 servings/wk (w  %)"}, {"label": "norat2005", "cohort": "norat2005", "rr": 1.17, "lo": 0.92, "hi": 1.49, "w": 11.112346381514735, "note": "SLR 2010 Fig 73: >80 vs <=10 g/day (w  %)"}, {"label": "english2004", "cohort": "english2004", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 7.141050494338231, "note": "SLR 2010 Fig 73: >=6.5 vs <=3 times/wk (w  %)"}, {"label": "tiemersma2002", "cohort": "tiemersma2002", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.4577506780916853, "note": "SLR 2010 Fig 73: >=5 vs 0-3 times/wk (w  %)"}, {"label": "jarvinen2001", "cohort": "jarvinen2001", "rr": 1.5, "lo": 0.77, "hi": 2.94, "w": 1.9024908338650357, "note": "SLR 2010 Fig 73: Q4 vs Q1 (w  %)"}, {"label": "pietinen1999", "cohort": "pietinen1999", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 4.186502908174451, "note": "SLR 2010 Fig 73: 99 vs 35 g (w  %)"}, {"label": "kato1997", "cohort": "kato1997", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.4069133374261016, "note": "SLR 2010 Fig 73: Q4 vs Q1 (w  %)"}], "loo": {}, "reproduced": true}], "deviations": [{"study": "nothlings2009", "class": "exposure", "text": "Nöthlings 2009 analyses 'red meat' and 'processed red meat' without defining red meat; the later full-cohort MEC paper (Ollberding 2012) separates 'total red meat' from 'red meat excluding processed', so the 2009 variable probably includes processed meat (inference, not printed)", "page": "SLR 2010 T37; Nöthlings 2009 Methods", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "nothlings2009", "class": "inclusion", "text": "Nöthlings 2009 is a nested case-control study of 1,009 cases; the full MEC cohort analysis (Ollberding 2012, 3,404 cases) appeared later", "page": "Nöthlings 2009; Ollberding 2012", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "norat2005", "class": "model", "text": "observed estimate; calibrated 1.49 (0.91–2.43) printed", "page": "Norat 2005 Table 4", "alternative": [1.49, 0.91, 2.43], "alt_note": "calibrated", "outcome": "colorectal"}, {"study": "english2004", "class": "model", "text": "model not adjusted for processed meat", "page": "English 2004", "alternative": [1.1225, 0.8888, 1.5666], "alt_note": "adjusted for processed meat", "outcome": "colorectal"}, {"study": "jarvinen2001", "class": "exposure", "text": "near-total meat", "page": "Järvinen 2001 Table 3", "alternative": "remove", "alt_note": "no red-meat row", "outcome": "colorectal"}, {"study": "lee2009", "class": "transcription", "text": "0.80 (0.52–1.23) here; 0.81 (0.50–1.29) in SLR 2016 from the same table", "page": "SLR 2010 Fig 70; SLR 2016 Fig 125", "alternative": null, "alt_note": "", "outcome": "colorectal"}], "notes": ["Chan 2011's colon set includes Larsson 2005 colon (Fig 4, weight 10.33 %); its Table S2 states only Larsson's colorectal and rectal results were used. The SLR 2010 Fig 74 set (9 rows) does not include it. Both are reproduced."]}, "larsson2006": {"id": "larsson2006", "title": "Larsson & Wolk 2006 (Int J Cancer 119:2657): red meat, highest vs lowest, 15 cohort studies", "runs": [{"name": "CRC HvL – published per-study values (Table I / Fig 1)", "k": 15, "re": [1.2820405407407736, 1.1538567619882258, 1.4244644588906668], "fe": [1.2820405407407736, 1.1538567619882258, 1.4244644588906668], "I2": 0.0, "Q": 4.8609160792367945, "tau2": 0.0, "published": [1.28, 1.15, 1.42], "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 4.077661545778968, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 3.1708582691350697, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 3.744609924958338, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 0.9, "hi": 4.3, "w": 1.8147256571718364, "note": "Table I p2658: 145 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 5.500178912317673, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 5.638022452393719, "note": "Table I p2658: 185 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "jarvinen2001", "cohort": "fmches", "rr": 1.5, "lo": 0.77, "hi": 2.94, "w": 2.4729058201290335, "note": "Table I p2658: 109 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 3.2422483133844326, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 14.261619903470454, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 4.131415520542922, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 5.228402066512194, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 10.774535133549259, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.32, "lo": 1.03, "hi": 1.68, "w": 18.545385669250603, "note": "Table I p2659: 733 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.36, "lo": 0.93, "hi": 2.0, "w": 7.570652683693477, "note": "Table I p2659: 1667 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "norat2005", "cohort": "epic", "rr": 1.35, "lo": 0.96, "hi": 1.88, "w": 9.826778127712029, "note": "Table I p2659: 1329 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}], "loo": {"bostick1994": [1.2934944748445742, 1.1615888247998216, 1.4403788334841925], "kato1997": [1.2837814434462367, 1.1534484368933167, 1.4288413264279596], "chen1998": [1.2866096980254724, 1.1556213368397237, 1.4324454406320677], "hsing1998": [1.2727525068179826, 1.1443878756296262, 1.4155156464937317], "singh1998": [1.2749611817585187, 1.1440224335141522, 1.420886485589157], "pietinen1999": [1.2938251869523694, 1.160857250277857, 1.4420236544946914], "jarvinen2001": [1.2769466101255285, 1.1477478620307107, 1.4206888978438785], "tiemersma2002": [1.2725580112714776, 1.143319292169615, 1.4164056385142978], "flood2003": [1.3151182321632804, 1.1736976819759923, 1.4735787512645433], "wei2004_nhs": [1.2852397194525575, 1.154141059976089, 1.4312298502686587], "wei2004_hpfs": [1.2844009019644105, 1.1526719091573918, 1.431184072294187], "english2004": [1.2684860506303688, 1.134624747265302, 1.4181401071341124], "larsson2005": [1.2735517287267797, 1.1332493179334069, 1.431224338789568], "chao2005": [1.2758566599473429, 1.1434449726799838, 1.423601708542878], "norat2005": [1.2748444358104802, 1.140982408698285, 1.424411387175653]}, "reproduced": true}, {"name": "CRC HvL – corrected: inclusion", "k": 14, "re": [1.2727525068179826, 1.1443878756296262, 1.4155156464937317], "fe": [1.2727525068179826, 1.1443878756296262, 1.4155156464937317], "I2": 0.0, "Q": 3.8707213285999367, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 4.153027603244474, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 3.229464184276307, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 3.813820300469384, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 5.601836883515748, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 5.742228139738901, "note": "Table I p2658: 185 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "jarvinen2001", "cohort": "fmches", "rr": 1.5, "lo": 0.77, "hi": 2.94, "w": 2.518611713091031, "note": "Table I p2658: 109 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 3.302173706887706, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 14.525212664451018, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 4.207775094784054, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 5.325036876972476, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 10.973677270512484, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.32, "lo": 1.03, "hi": 1.68, "w": 18.888153843209412, "note": "Table I p2659: 733 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.36, "lo": 0.93, "hi": 2.0, "w": 7.710578530604743, "note": "Table I p2659: 1667 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "norat2005", "cohort": "epic", "rr": 1.35, "lo": 0.96, "hi": 1.88, "w": 10.008403188242266, "note": "Table I p2659: 1329 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}], "loo": {"bostick1994": [1.2839391525509385, 1.1518185087704178, 1.431214844092945], "kato1997": [1.2742046011784576, 1.1436795744154404, 1.4196260928190558], "chen1998": [1.2770076657125875, 1.1458198601353493, 1.4232154940097483], "singh1998": [1.265041252376286, 1.1339235395330596, 1.4113203531101968], "pietinen1999": [1.2841133198806123, 1.1509250892770038, 1.432714460443863], "jarvinen2001": [1.2673616806892465, 1.1379867607921543, 1.4114449174798744], "tiemersma2002": [1.2628458128290818, 1.1334382955191042, 1.4070281137356047], "flood2003": [1.3046968105115948, 1.162973214575438, 1.4636912923059506], "wei2004_nhs": [1.2755823915098976, 1.1442861760247354, 1.4219436288068354], "wei2004_hpfs": [1.2746201732448434, 1.142692534194757, 1.4217792953268857], "english2004": [1.2578904617301754, 1.1238522043287102, 1.407915033326711], "larsson2005": [1.2619952101460452, 1.1214819705314807, 1.4201136998009858], "chao2005": [1.2657216434785086, 1.1331240255528072, 1.4138357696443318], "norat2005": [1.2644393246928394, 1.1303879442486606, 1.4143877011112047]}}, {"name": "CRC HvL – corrected: exposure", "k": 14, "re": [1.2126871295324706, 1.0971852596559333, 1.3403480052173433], "fe": [1.2126871295324706, 1.0971852596559333, 1.3403480052173433], "I2": 0.0, "Q": 8.062799867118493, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 3.681179838651355, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.8625474185428303, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 3.3805116988288657, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 0.9, "hi": 4.3, "w": 1.638275130700709, "note": "Table I p2658: 145 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 4.965382117590949, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 5.228359796063862, "note": "exposure: unprocessed red meat Q4 vs Q1, multivariate"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.9269960218957056, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 12.87492526433681, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 3.7297071737248793, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 4.720030845995831, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 9.726898875538058, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.22, "lo": 0.98, "hi": 1.53, "w": 20.193377478746225, "note": "exposure: red meat main dish (unprocessed) ≥4 servings/week"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.36, "lo": 0.93, "hi": 2.0, "w": 6.834538303820974, "note": "Table I p2659: 1667 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "norat2005", "cohort": "epic", "rr": 1.17, "lo": 0.92, "hi": 1.49, "w": 17.23727003556295, "note": "exposure: fresh red meat ≥80 vs <10 g/day, model ‡"}], "loo": {"bostick1994": [1.2198278516568668, 1.1015567325713305, 1.3507974157667402], "kato1997": [1.2121806492485712, 1.0951224984298016, 1.3417511999977203], "chen1998": [1.2142085356679566, 1.0966563923721782, 1.3443612587711806], "hsing1998": [1.2036517253811878, 1.0881068235407714, 1.3314662169829], "singh1998": [1.2031729641661972, 1.085770745876241, 1.333269649415916], "pietinen1999": [1.2408387515525152, 1.1196018238298604, 1.375203911411617], "tiemersma2002": [1.2025946639380252, 1.086425594674868, 1.33118543305768], "flood2003": [1.2302912831963853, 1.1051925806843763, 1.3695501290568928], "wei2004_nhs": [1.2127913543916877, 1.0951743272727266, 1.343039945932682], "wei2004_hpfs": [1.2113498396163813, 1.093294354618134, 1.3421531243991063], "english2004": [1.1940634956107352, 1.0746737494567355, 1.3267167196285257], "larsson2005": [1.2108437216822037, 1.0825043477667569, 1.3543987341592776], "chao2005": [1.2025307938865224, 1.0840796719213512, 1.333924385541159], "norat2005": [1.2217718281242271, 1.0944818172490678, 1.3638658737610811]}}, {"name": "CRC HvL – corrected: model", "k": 15, "re": [1.2773935537653711, 1.1596218398011795, 1.4071262158024633], "fe": [1.2773935537653711, 1.1596218398011795, 1.4071262158024633], "I2": 0.0, "Q": 4.764212006315342, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 3.437973873798877, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.6734263656801334, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 3.1571700949288592, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 0.9, "hi": 4.3, "w": 1.530038559460045, "note": "Table I p2658: 145 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 4.637332252683408, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 4.753551434715315, "note": "Table I p2658: 185 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "jarvinen2001", "cohort": "fmches", "rr": 1.5, "lo": 0.77, "hi": 2.94, "w": 2.0849659802612877, "note": "Table I p2658: 109 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.733617017656319, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 12.024312482956438, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 3.4832951342263456, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 4.408190700621562, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 9.084267999097532, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.32, "lo": 1.03, "hi": 1.68, "w": 15.636057748934066, "note": "Table I p2659: 733 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.2828350156563866, "lo": 1.0441240901214999, "hi": 1.5761207819681886, "w": 22.0706089315611, "note": "model: fixed-effect pool of colon and rectum as fn 6 states"}, {"label": "norat2005", "cohort": "epic", "rr": 1.35, "lo": 0.96, "hi": 1.88, "w": 8.285191423418716, "note": "Table I p2659: 1329 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}], "loo": {"bostick1994": [1.2867786056059445, 1.1661494451545933, 1.4198859217616604], "kato1997": [1.2787208428953154, 1.1592960687232208, 1.4104481488113187], "chen1998": [1.2810559087541145, 1.1611290357741813, 1.413369393746687], "hsing1998": [1.2695373976682276, 1.1516275802895861, 1.3995194554761654], "singh1998": [1.2712730351097057, 1.1513867482760156, 1.4036422880642847], "pietinen1999": [1.2869608704194477, 1.1655247413833825, 1.4210494408080325], "jarvinen2001": [1.2730314639711913, 1.1544786468029782, 1.4037584088267727], "tiemersma2002": [1.269334953514893, 1.150751859090852, 1.4001378416086925], "flood2003": [1.3037654855716434, 1.1760133663588026, 1.445395511643574], "wei2004_nhs": [1.2798947484529435, 1.1598841125592056, 1.412322618595921], "wei2004_hpfs": [1.2791448899547442, 1.158653881734174, 1.4121660275701946], "english2004": [1.2657489824004065, 1.143643019683121, 1.4008921130752652], "larsson2005": [1.2696492600240248, 1.142741199159077, 1.4106511996467814], "chao2005": [1.2758566599473429, 1.1434449726799838, 1.423601708542878], "norat2005": [1.2710300773028527, 1.1489233892914963, 1.4061141695485309]}}, {"name": "CRC HvL – corrected: all classes", "k": 13, "re": [1.2106853407437248, 1.1028702573000342, 1.3290402788448683], "fe": [1.2106853407437248, 1.1028702573000342, 1.3290402788448683], "I2": 0.0, "Q": 6.737149785977535, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 3.1966036794882213, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.485732838897621, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 2.9355143211336006, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 4.311758578187605, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 4.540118900550383, "note": "exposure: unprocessed red meat Q4 vs Q1, multivariate"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.541697679423086, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 11.180120308437012, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 3.238743065405486, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 4.098704391235575, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 8.446487837699912, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.22, "lo": 0.98, "hi": 1.53, "w": 17.53520001171785, "note": "exposure: red meat main dish (unprocessed) ≥4 servings/week"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.2828350156563866, "lo": 1.0441240901214999, "hi": 1.5761207819681886, "w": 20.521095362838423, "note": "model: fixed-effect pool of colon and rectum as fn 6 states"}, {"label": "norat2005", "cohort": "epic", "rr": 1.17, "lo": 0.92, "hi": 1.49, "w": 14.968223024985223, "note": "exposure: fresh red meat ≥80 vs <10 g/day, model ‡"}], "loo": {"bostick1994": [1.2167760198396578, 1.106726767272347, 1.3377682064253371], "kato1997": [1.2101969760207798, 1.1011238603061138, 1.3300744571665952], "chen1998": [1.211937581615076, 1.102466579574243, 1.3322786639919966], "singh1998": [1.202399614206924, 1.093048405805207, 1.3226905821978854], "pietinen1999": [1.234779414285389, 1.1223555201880535, 1.3584645636059276], "tiemersma2002": [1.2019137652671323, 1.0935575495410799, 1.3210065622470912], "flood2003": [1.22538484270507, 1.1099203251874108, 1.3528610825986886], "wei2004_nhs": [1.2107082868295134, 1.1011850915020611, 1.3311245921412036], "wei2004_hpfs": [1.2094480282534226, 1.0995723257755974, 1.3303031540142771], "english2004": [1.1945659802885014, 1.0836174018561404, 1.3168742757529774], "larsson2005": [1.2087138719396124, 1.0907303684854646, 1.3394595643723655], "chao2005": [1.1927251379109618, 1.0742468933924767, 1.3242702988995079], "norat2005": [1.2179922850515237, 1.1008214670389567, 1.3476346990538226]}}, {"name": "CRC HvL – corrected: errors only (model choices as published)", "k": 13, "re": [1.2036517253811878, 1.0881068235407714, 1.3314662169829], "fe": [1.2036517253811878, 1.0881068235407714, 1.3314662169829], "I2": 0.0, "Q": 6.775166394589668, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 3.74249215692671, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.9102249094823365, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 3.4368162039866714, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 5.048083616049668, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 5.315441349784362, "note": "exposure: unprocessed red meat Q4 vs Q1, multivariate"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.975746944032375, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 13.089365077162588, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 1.21, "lo": 0.72, "hi": 2.03, "w": 3.791827744664731, "note": "Table I p2658: 876 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 1.24, "lo": 0.78, "hi": 1.96, "w": 4.798645867859368, "note": "Table I p2659: 602 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 9.88890636928432, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.22, "lo": 0.98, "hi": 1.53, "w": 20.52971062227579, "note": "exposure: red meat main dish (unprocessed) ≥4 servings/week"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.36, "lo": 0.93, "hi": 2.0, "w": 6.94837175019302, "note": "Table I p2659: 1667 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "norat2005", "cohort": "epic", "rr": 1.17, "lo": 0.92, "hi": 1.49, "w": 17.524367388298064, "note": "exposure: fresh red meat ≥80 vs <10 g/day, model ‡"}], "loo": {"bostick1994": [1.2105102171936064, 1.0921825496438418, 1.3416575703466005], "kato1997": [1.2028707206160256, 1.0857694361767438, 1.3326014919062317], "chen1998": [1.2048671112406852, 1.087268203349166, 1.3351855147402596], "singh1998": [1.1935688095035946, 1.0761384643972123, 1.3238133847560283], "pietinen1999": [1.2315737041484782, 1.1102419742014586, 1.3661650559022893], "tiemersma2002": [1.1931895111495407, 1.0769934663919258, 1.3219218629866645], "flood2003": [1.2200870338135332, 1.0949056780991875, 1.3595804641950648], "wei2004_nhs": [1.2034022058430083, 1.0857407157422863, 1.333814646563886], "wei2004_hpfs": [1.201848054312671, 1.0837502784872397, 1.3328151090963345], "english2004": [1.1838558671462915, 1.0644546669717412, 1.316650448030686], "larsson2005": [1.1994641695691572, 1.0710791847260257, 1.3432380300138504], "chao2005": [1.1927251379109618, 1.0742468933924767, 1.3242702988995079], "norat2005": [1.2109257701017087, 1.0835673559666095, 1.353253411171979]}}, {"name": "CRC HvL – corrected + follow-ups", "k": 13, "re": [1.1476976162253911, 1.05450328314777, 1.2491282287500107], "fe": [1.1476976162253911, 1.05450328314777, 1.2491282287500107], "I2": 0.0, "Q": 11.497227249500503, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 2.635386511821576, "note": "Table I p2658: 212 cases; total red meat (both reported) | from Fig 1 p. 2660 (render"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 2.0493209207190626, "note": "Table I p2658: 100 cases; excluded from type-of-meat strata (items not specified) | f"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 2.42013575120865, "note": "Table I p2658: 212 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 3.5547573420192777, "note": "Table I p2658: 157 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 3.7430251955701572, "note": "exposure: unprocessed red meat Q4 vs Q1, multivariate"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 1.6, "lo": 0.9, "hi": 2.9, "w": 2.095460198729488, "note": "Table I p2658: 102 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "flood2003", "cohort": "bcddp", "rr": 1.1, "lo": 0.83, "hi": 1.45, "w": 9.217263450724232, "note": "Table I p2658: 487 cases; total red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "wei2004_nhs", "cohort": "nhs", "rr": 0.96, "lo": 0.76, "hi": 1.21, "w": 13.264512093301972, "note": "follow-up: NHS → Bernstein 2015 women >1 svg/d vs lowest, unprocessed red meat"}, {"label": "wei2004_hpfs", "cohort": "hpfs", "rr": 0.98, "lo": 0.75, "hi": 1.27, "w": 10.341394171930409, "note": "follow-up: HPFS → Bernstein 2015 men >1 svg/d vs lowest, unprocessed red meat"}, {"label": "english2004", "cohort": "mccs", "rr": 1.4, "lo": 1.0, "hi": 1.9, "w": 6.96356581911435, "note": "Table I p2659: 451 cases; fresh red meat only | from Fig 1 p. 2660 (rendered): RR (95"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.22, "lo": 0.98, "hi": 1.53, "w": 14.456602765461795, "note": "exposure: red meat main dish (unprocessed) ≥4 servings/week"}, {"label": "chao2005", "cohort": "cps2", "rr": 1.2828350156563866, "lo": 1.0441240901214999, "hi": 1.5761207819681886, "w": 16.918274315346807, "note": "model: fixed-effect pool of colon and rectum as fn 6 states"}, {"label": "norat2005", "cohort": "epic", "rr": 1.17, "lo": 0.92, "hi": 1.49, "w": 12.340301464052217, "note": "exposure: fresh red meat ≥80 vs <10 g/day, model ‡"}], "loo": {"bostick1994": [1.1507036684216772, 1.0539717732129024, 1.25631346699418], "kato1997": [1.1457611236130474, 1.0492530844632784, 1.2511457643744262], "chen1998": [1.1469061427289295, 1.0498333266214972, 1.2529547947029485], "singh1998": [1.1390235478288024, 1.0449162574200155, 1.2416063328479907], "pietinen1999": [1.1639178682259228, 1.0676637849144348, 1.2688496351725052], "tiemersma2002": [1.1395651871699295, 1.0460877485657325, 1.241395683670065], "flood2003": [1.1524906798864842, 1.051875900528747, 1.2627295354495207], "wei2004_nhs": [1.1794735458006793, 1.0769519190521002, 1.2917548319780896], "wei2004_hpfs": [1.1687997123732954, 1.0688021351190427, 1.278153105010165], "english2004": [1.1307538600520715, 1.0357070623045508, 1.234523098816801], "larsson2005": [1.1359005191966158, 1.0354581528804552, 1.2460860788259247], "chao2005": [1.1219748677146832, 1.022426732355304, 1.231215464098336], "norat2005": [1.1443660168400702, 1.042326304503008, 1.2563950222121913]}}, {"name": "DR reconstruction per 120 g – our GL values for Larsson's DR studies where gram doses exist", "k": 8, "re": [1.2651729482098608, 1.0958260183572637, 1.4606904399674325], "fe": [1.2651729482098608, 1.0958260183572637, 1.4606904399674325], "I2": 0.0, "Q": 4.01006689739562, "tau2": 0.0, "published": [1.28, 1.18, 1.39], "comment": "not reproducible from the paper; studies without gram-based categories in our table: chen1998, hsing1998, flood2003, wei2004, chao2005", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 0.9250029663381212, "lo": 0.36392328672698904, "hi": 2.351536840046294, "w": 2.372509263273523, "note": "database GL/continuous per 100 g → per 120 g (colon, red_main_dish)"}, {"label": "singh1998", "cohort": "ahs", "rr": 2.9868192194663825, "lo": 0.3964004004001619, "hi": 22.506497628115092, "w": 0.5062899362131162, "note": "database GL/continuous per 100 g → per 120 g (colon, red_undefined)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8040337313703267, "lo": 0.36453174099925506, "hi": 1.773395958321603, "w": 3.3002141212742337, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_unprocessed)"}, {"label": "jarvinen2001", "cohort": "fmches", "rr": 1.4702850106490482, "lo": 0.9030150588902051, "hi": 2.3939443975216146, "w": 8.689678942588849, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_undefined)"}, {"label": "tiemersma2002", "cohort": "monica_nl", "rr": 2.186337110723703, "lo": 0.8293253316840454, "hi": 5.764099491597568, "w": 2.1974227909922663, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_unprocessed)"}, {"label": "english2004", "cohort": "mccs", "rr": 1.2298933623228532, "lo": 0.8680902033699593, "hi": 1.7137589924928207, "w": 17.85533468545099, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_unprocessed)"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.2759932758156731, "lo": 0.8786492067376667, "hi": 1.8531675900826612, "w": 14.83162376949722, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_main_dish)"}, {"label": "norat2005", "cohort": "epic", "rr": 1.2570207430874425, "lo": 1.0240477462785176, "hi": 1.5360425453326891, "w": 50.2469264907098, "note": "database GL/continuous per 100 g → per 120 g (colorectal, red_unprocessed)"}], "loo": {"bostick1994": [1.2748382529390987, 1.1022828148165886, 1.4744061590284672], "singh1998": [1.2596547412680916, 1.0906481077797012, 1.454850612109332], "pietinen1999": [1.2848989019698853, 1.1102087699624543, 1.487076334606193], "jarvinen2001": [1.2472115705572946, 1.0730741450885994, 1.44960784755797], "tiemersma2002": [1.2497186476668365, 1.080704007813127, 1.4451660094114216], "english2004": [1.2729743819248596, 1.0863304428557017, 1.4916858748588215], "larsson2005": [1.2632980478600815, 1.0811388561805066, 1.4761489225955984], "norat2005": [1.2734597335209192, 1.038742313715104, 1.561214626079009]}, "reproduced": false}], "deviations": [{"study": "hsing1998", "class": "inclusion", "text": "Lutheran Brotherhood: fatal cases only (mortality); Larsson's own sensitivity analysis excluding mortality studies gives 1.27 (1.14–1.42)", "page": "Table I fn7; text p2660", "alternative": "remove", "alt_note": "mortality study", "outcome": "colorectal"}, {"study": "pietinen1999", "class": "exposure", "text": "Larsson's row 203 vs 79 g/day is ATBC's red meat *including* processed (Chan 2011 S1; Pietinen Table 5); the unprocessed row (99 vs 35 g/day) gives 0.8 (0.5–1.2)", "page": "Pietinen 1999 Table 5", "alternative": [0.8, 0.5, 1.2], "alt_note": "unprocessed red meat Q4 vs Q1, multivariate", "outcome": "colorectal"}, {"study": "norat2005", "class": "exposure", "text": "Larsson chose EPIC's total red meat (fresh + processed, ≥160 vs <20 g) 1.35 (0.96–1.88); the fresh red meat row (≥80 vs <10 g) is 1.17 (0.92–1.49) — as WCRF 2007 Fig 4.3.1 uses", "page": "Norat 2005 Table 3; Larsson Table I fn 4 (stated rule: total red meat preferred)", "alternative": [1.17, 0.92, 1.49], "alt_note": "fresh red meat ≥80 vs <10 g/day, model ‡", "outcome": "colorectal"}, {"study": "larsson2005", "class": "exposure", "text": "SMC total red meat (incl. processed) ≥94 g vs <47 g 1.32 (1.03–1.68); the paper's unprocessed 'red meat as main dish' top category gives 1.22 (0.98–1.53)", "page": "Larsson 2005 Table II", "alternative": [1.22, 0.98, 1.53], "alt_note": "red meat main dish (unprocessed) ≥4 servings/week", "outcome": "colorectal"}, {"study": "chao2005", "class": "exposure", "text": "CPS-II Nutrition Cohort 'red meat' includes processed meat (beef, pork, lamb and processed); no unprocessed row exists", "page": "Chao 2005 Methods", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "chao2005", "class": "model", "text": "Larsson's CRC row for Chao, 1.36 (0.93–2.00), is a random-effects pool of Chao's colon 1.15 (0.90–1.46) and rectum 1.71 (1.15–2.52); footnote 6 says inverse-variance weighting, which as a fixed-effect pool gives 1.28 (1.04–1.58)", "page": "Larsson Table I fn 6; Chao 2005 Table 2", "alternative": [1.2828350156563866, 1.0441240901214999, 1.5761207819681886], "alt_note": "fixed-effect pool of colon and rectum as fn 6 states", "outcome": "colorectal"}, {"study": "bostick1994", "class": "exposure", "text": "Table II fn 4 lists Bostick as reporting both total and fresh red meat; Larsson's row 1.04 (0.62–1.76) is the paper's 'red meat' (>11 vs <4 servings/week) and the main-dish variable includes ham — neither is a clean unprocessed row", "page": "Larsson Table II fn 4; Bostick 1994 Table 3", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "flood2003", "class": "exposure", "text": "BCDDP 'red meat' includes processed meat; no unprocessed row", "page": "Flood 2003 Methods", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "singh1998", "class": "cases", "text": "157 colon cases include 22 rectosigmoid cases", "page": "Singh 1998 Methods", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "chen1998", "class": "inclusion", "text": "Physicians' Health Study nested case-control (212 cases); Larsson's sensitivity excluding nested case-control studies gives 1.28 (1.15–1.42)", "page": "Table I; text p2660", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "wei2004_nhs", "class": "exposure", "text": "'red meat as main dish' excludes hamburger and mixed dishes (both NHS and HPFS)", "page": "Wei 2004 Table II", "alternative": null, "alt_note": "", "outcome": "colorectal"}, {"study": "jarvinen2001", "class": "exposure", "text": "Järvinen's 'red meat' row is near-total meat (quartile cut-points 91–94 % of those for 'Meat, all'); Larsson's own Table II fn 4 excludes it from the type-of-meat strata (items not specified). Same deviation as in CUP 2010/2016 (correction R106)", "page": "Järvinen 2001 Tables 2–3; Larsson Table II fn 4", "alternative": "remove", "alt_note": "no red-meat row in the paper", "outcome": "colorectal"}], "notes": ["Per-study per-120 g estimates (Table III, 1.28 (1.18–1.39), 14 studies) are not printed anywhere in the paper; the dose-response analysis cannot be reproduced from printed values (protocol R3). Our own GL per-100 g reconstruction for the same 14 studies is reported under 'DR reconstruction'."]}, "wcrf2007": {"id": "wcrf2007", "title": "WCRF/AICR Second Expert Report 2007 (Fig 4.3.2: red meat 'per time/week', cohort studies — the values are per time/day, see deviations)", "runs": [{"name": "Per time/day – published per-study values (Fig 4.3.2, 9 rows / 7 studies; axis labelled per time/week)", "k": 9, "re": [1.4268048291122086, 1.0505382933559568, 1.9378370434024077], "fe": [1.149449379715366, 1.0015680590796636, 1.3191653473275848], "I2": 57.88895546057389, "Q": 18.997391509750056, "tau2": 0.09180122884622877, "published": [1.43, 1.05, 1.94], "comment": "", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.81, "lo": 1.17, "hi": 2.8, "w": 17.258920369748026, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 0.96, "lo": 0.8, "hi": 1.14, "w": 24.40523435623224, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 2.2, "lo": 1.24, "hi": 3.91, "w": 13.734248234452606, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "singh1998", "cohort": "ahs", "rr": 4.51, "lo": 0.38, "hi": 53.27, "w": 1.4505591003836558, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_rapid", "cohort": "phs", "rr": 2.57, "lo": 0.78, "hi": 8.84, "w": 5.132054704609153, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_slow", "cohort": "phs", "rr": 0.88, "lo": 0.45, "hi": 1.75, "w": 11.516512436820065, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_men", "cohort": "monica_nl_men", "rr": 3.44, "lo": 0.83, "hi": 14.18, "w": 3.9603154927828346, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_women", "cohort": "monica_nl_women", "rr": 1.42, "lo": 0.22, "hi": 9.0, "w": 2.4687565298714116, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "english2004", "cohort": "mccs", "rr": 1.23, "lo": 0.88, "hi": 1.73, "w": 20.073398775100003, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}], "loo": {}, "reproduced": true}, {"name": "Per time/day – corrected: duplicate", "k": 8, "re": [1.4089277522007062, 1.0445030408719196, 1.900499408086215], "fe": [1.149449379715366, 1.0015680590796636, 1.3191653473275848], "I2": 58.125531264547035, "Q": 16.71662999290415, "tau2": 0.08125547289032715, "published": null, "comment": "", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.81, "lo": 1.17, "hi": 2.8, "w": 17.82535814823528, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 0.96, "lo": 0.8, "hi": 1.14, "w": 26.07668693823499, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 2.2, "lo": 1.24, "hi": 3.91, "w": 13.955244973726439, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "singh1998", "cohort": "ahs", "rr": 4.51, "lo": 0.38, "hi": 53.27, "w": 1.3951451719544234, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_rapid", "cohort": "phs", "rr": 1.1361221508551176, "lo": 0.6281276538282716, "hi": 2.0549541702180054, "w": 13.503088380197958, "note": "duplicate: NAT2 strata combined (fixed)"}, {"label": "tiemersma2002_men", "cohort": "monica_nl_men", "rr": 3.44, "lo": 0.83, "hi": 14.18, "w": 3.8510673254024486, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_women", "cohort": "monica_nl_women", "rr": 1.42, "lo": 0.22, "hi": 9.0, "w": 2.3850090140887428, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "english2004", "cohort": "mccs", "rr": 1.23, "lo": 0.88, "hi": 1.73, "w": 21.00840004815972, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}], "loo": {"willett1990": [1.314030808648435, 0.9647204372542655, 1.789821070849948], "bostick1994": [1.5396778592131588, 1.205593692901751, 1.9663406702513386], "giovannucci1994": [1.2790718557034708, 0.965067046540745, 1.6952447168484346], "singh1998": [1.3851034788940957, 1.0257919373590347, 1.8702736660066313], "chen1998_rapid": [1.4837735367028322, 1.047409311091577, 2.1019327257318436], "tiemersma2002_men": [1.3517372193607158, 1.0081683950982498, 1.8123891991545447], "tiemersma2002_women": [1.4182120132544453, 1.03625509665871, 1.940955775295604], "english2004": [1.5181872610619154, 1.0177246325807239, 2.2647506858569244]}}, {"name": "Per time/day – corrected: inclusion", "k": 7, "re": [1.142276330538891, 0.8776134805824141, 1.4867538434385574], "fe": [1.042175055536652, 0.8970026735402425, 1.2108423736310039], "I2": 27.61233248324161, "Q": 8.288704700439403, "tau2": 0.0302271039453886, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 0.96, "lo": 0.8, "hi": 1.14, "w": 47.10625629480699, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "singh1998", "cohort": "ahs", "rr": 4.51, "lo": 0.38, "hi": 53.27, "w": 1.1161090415685258, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_rapid", "cohort": "phs", "rr": 2.57, "lo": 0.78, "hi": 8.84, "w": 4.3702784094204485, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_slow", "cohort": "phs", "rr": 0.88, "lo": 0.45, "hi": 1.75, "w": 12.03487429293209, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_men", "cohort": "monica_nl_men", "rr": 3.44, "lo": 0.83, "hi": 14.18, "w": 3.261655335221414, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_women", "cohort": "monica_nl_women", "rr": 1.42, "lo": 0.22, "hi": 9.0, "w": 1.9516027868417112, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "english2004", "cohort": "mccs", "rr": 1.23, "lo": 0.88, "hi": 1.73, "w": 30.159223839208813, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}], "loo": {}}, {"name": "Per time/day – corrected: all classes", "k": 6, "re": [1.09809303362279, 0.8853090409846338, 1.3620196503921518], "fe": [1.042175055536652, 0.8970026735402425, 1.2108423736310039], "I2": 16.776842802807945, "Q": 6.007943183593496, "tau2": 0.013356869285061237, "published": null, "comment": "", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 0.96, "lo": 0.8, "hi": 1.14, "w": 56.12046783597842, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "singh1998", "cohort": "ahs", "rr": 4.51, "lo": 0.38, "hi": 53.27, "w": 0.7532147471473079, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_rapid", "cohort": "phs", "rr": 1.1361221508551176, "lo": 0.6281276538282716, "hi": 2.0549541702180054, "w": 11.525886365979003, "note": "duplicate: NAT2 strata combined (fixed)"}, {"label": "tiemersma2002_men", "cohort": "monica_nl_men", "rr": 3.44, "lo": 0.83, "hi": 14.18, "w": 2.2465918424170335, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_women", "cohort": "monica_nl_women", "rr": 1.42, "lo": 0.22, "hi": 9.0, "w": 1.3275096121922245, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "english2004", "cohort": "mccs", "rr": 1.23, "lo": 0.88, "hi": 1.73, "w": 28.026329596286022, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}], "loo": {"bostick1994": [1.283974820186424, 0.9682238521771195, 1.7026964737191574], "singh1998": [1.0734437415769043, 0.8806212512661754, 1.308487008090992], "chen1998_rapid": [1.1420252175120873, 0.84981600501292, 1.534710560568581], "tiemersma2002_men": [1.0282061664029598, 0.8842319753581556, 1.1956228117636802], "tiemersma2002_women": [1.1232643692324207, 0.8692432496610834, 1.4515187131784482], "english2004": [1.1023019575951392, 0.7965933885910516, 1.52533227506092]}}, {"name": "Per time/day – corrected + follow-ups", "k": 7, "re": [1.0212473388839984, 0.9192168090023728, 1.1346029761026228], "fe": [1.0182754217297347, 0.9219983052297074, 1.124606009162391], "I2": 2.779740559626754, "Q": 6.171553166528934, "tau2": 0.0007630313204602455, "published": null, "comment": "Willett 1990 and Giovannucci 1994 replaced by the same cohorts' 2015 follow-up (2,731 cases) on the per-serving/day scale (1.2 × log RR per 100 g).", "rows": [{"label": "bostick1994", "cohort": "iwhs", "rr": 0.96, "lo": 0.8, "hi": 1.14, "w": 32.309908396918395, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "singh1998", "cohort": "ahs", "rr": 4.51, "lo": 0.38, "hi": 53.27, "w": 0.18129605936914844, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "chen1998_rapid", "cohort": "phs", "rr": 1.1361221508551176, "lo": 0.6281276538282716, "hi": 2.0549541702180054, "w": 3.128453739721281, "note": "duplicate: NAT2 strata combined (fixed)"}, {"label": "tiemersma2002_men", "cohort": "monica_nl_men", "rr": 3.44, "lo": 0.83, "hi": 14.18, "w": 0.549369291901563, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "tiemersma2002_women", "cohort": "monica_nl_women", "rr": 1.42, "lo": 0.22, "hi": 9.0, "w": 0.32146712314808945, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "english2004", "cohort": "mccs", "rr": 1.23, "lo": 0.88, "hi": 1.73, "w": 9.456524995877848, "note": "Fig 4.3.2 p121; 10 PDF excerpt (p121) confirms values and the axis"}, {"label": "willett1990", "cohort": "nhs_hpfs", "rr": 1.0, "lo": 0.869496839965074, "hi": 1.133411394847993, "w": 54.05298039306366, "note": "follow-up: NHS+HPFS → Bernstein 2015 Suppl. S5, unprocessed per 100 g → per 120 g/day (one serving/day)"}], "loo": {"bostick1994": [1.085027232246809, 0.9139825986595916, 1.288081519761674], "singh1998": [1.0158270235802094, 0.9197075443315745, 1.1219920377904427], "chen1998_rapid": [1.0309899581096749, 0.9016387642721772, 1.1788981750147112], "tiemersma2002_men": [1.012191325797367, 0.9162657021034721, 1.1181595880620807], "tiemersma2002_women": [1.0332458416473007, 0.9073809571555409, 1.1765697316683206], "english2004": [1.0002544536728815, 0.9015352636610684, 1.10978351310346], "willett1990": [1.09809303362279, 0.8853090409846338, 1.3620196503921518]}}, {"name": "Per 100 g/day – Fig 4.3.3 (3 studies; Larsson's upper limit read off the figure as 1.94)", "k": 3, "re": [1.2887852227394434, 1.039098020352604, 1.5984703250497292], "fe": [1.288735435153333, 1.0465859942213365, 1.5869111864577552], "I2": 5.609991257523717, "Q": 2.1188683279568163, "tau2": 0.0021401520570184128, "published": [1.29, 1.05, 1.59], "comment": "The figure's summary 1.29 (1.05–1.59) is the fixed-effect pool; the text's 1.29 (1.04–1.60) is the random-effects pool. SLR 2010 Table 36's 1.29 (0.94–1.78) is not reproduced.", "rows": [{"label": "pietinen1999", "cohort": "atbc", "rr": 1.05, "lo": 0.74, "hi": 1.48, "w": 36.13550940540641, "note": "Fig 4.3.3 p121 as printed"}, {"label": "norat2005", "cohort": "epic", "rr": 1.49, "lo": 0.91, "hi": 2.43, "w": 18.59425582320422, "note": "Fig 4.3.3 p121 as printed (EPIC calibrated estimate)"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.43, "lo": 1.05, "hi": 1.94, "w": 45.27023477138937, "note": "Fig 4.3.3 p121: printed '1.43 (1.05–0.95)'; upper limit 1.94 by calibrated pixel reading of the author-supplied PDF"}], "loo": {"pietinen1999": [1.4466064627974344, 1.1150852563613465, 1.876690814687957], "norat2005": [1.2388014069255728, 0.9159438290209936, 1.675461832022021], "larsson2005": [1.195732140994192, 0.858409251311889, 1.6656103726998024]}, "reproduced": true}, {"name": "Per 100 g/day – corrected: errors only (exposure; model choices as published)", "k": 3, "re": [1.2197821075593054, 0.9556413672174405, 1.5569317538587477], "fe": [1.2197821075593054, 0.9556413672174405, 1.5569317538587477], "I2": 0.0, "Q": 1.9180618066643256, "tau2": 0.0, "published": null, "comment": "R105: Pietinen and Larsson replaced by the papers' red meat rows without processed meat; Norat's calibrated EPIC estimate kept as published. Fixed and random effects coincide (tau² = 0).", "rows": [{"label": "pietinen1999", "cohort": "atbc", "rr": 0.8338, "lo": 0.4313, "hi": 1.6119, "w": 13.706540461880143, "note": "exposure: unprocessed red meat, GL (R105)"}, {"label": "norat2005", "cohort": "epic", "rr": 1.49, "lo": 0.91, "hi": 2.43, "w": 24.69434995261663, "note": "Fig 4.3.3 p121 as printed (EPIC calibrated estimate)"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.2252, "lo": 0.8978, "hi": 1.6721, "w": 61.59910958550323, "note": "exposure: unprocessed red meat as main dish, GL with 120 g/serving (R105)"}], "loo": {"pietinen1999": [1.2957620706869402, 0.9963930673601562, 1.6850773041599414], "norat2005": [1.13306311980827, 0.8364710909879975, 1.5348193706888922], "larsson2005": [1.1639915742022733, 0.6631978723244829, 2.0429444082278145]}}, {"name": "Per 100 g/day – corrected: all classes", "k": 3, "re": [1.1916698800165415, 1.031010855223674, 1.377363871334369], "fe": [1.1916698800165415, 1.031010855223674, 1.377363871334369], "I2": 0.0, "Q": 1.189430585721829, "tau2": 0.0, "published": null, "comment": "R105 plus Norat 2005 observed instead of calibrated.", "rows": [{"label": "pietinen1999", "cohort": "atbc", "rr": 0.8338, "lo": 0.4313, "hi": 1.6119, "w": 4.82637285292628, "note": "exposure: unprocessed red meat, GL (R105)"}, {"label": "norat2005", "cohort": "epic", "rr": 1.21, "lo": 1.02, "hi": 1.43, "w": 73.48323261646706, "note": "model: observed estimate"}, {"label": "larsson2005", "cohort": "smc", "rr": 1.2252, "lo": 0.8978, "hi": 1.6721, "w": 21.69039453060665, "note": "exposure: unprocessed red meat as main dish, GL with 120 g/serving (R105)"}], "loo": {"pietinen1999": [1.2134474560528639, 1.0460520308837942, 1.4076304859875004], "norat2005": [1.13306311980827, 0.8364710909879975, 1.5348193706888922], "larsson2005": [1.1575809973954871, 0.9139976248829654, 1.4660801396532215]}}], "deviations": [{"study": "english2004", "class": "transcription", "text": "Fig 4.3.2 is labelled 'per time/week', but English 2004 prints 1.03 (0.98–1.08) per serving/week and the figure's 1.23 (0.88–1.73) equals 1.03^7 = 1.23 (0.87–1.71); SLR 2010 calls the same analysis 'per time/day' (p156, Table 36). The increment is per time/day; Willett's 1.81 and Giovannucci's 2.20 are likewise implausible as weekly slopes", "page": "SER Fig 4.3.2 p121; SLR 2010 p156–157; English 2004 Table 3", "alternative": null, "alt_note": "", "outcome": "colorectal/colon"}, {"study": "chen1998_rapid", "class": "duplicate", "text": "Chen 1998 entered twice, split by NAT2 genotype (rapid / slow acetylators); one study", "page": "Fig 4.3.2", "alternative": [1.1361221508551176, 0.6281276538282716, 2.0549541702180054], "alt_note": "NAT2 strata combined (fixed)", "outcome": "colorectal/colon"}, {"study": "chen1998_slow", "class": "duplicate", "text": "see rapid row", "page": "Fig 4.3.2", "alternative": "remove", "alt_note": "", "outcome": "colorectal/colon"}, {"study": "chen1998_rapid", "class": "inclusion", "text": "Physicians' Health Study nested case-control", "page": "Chen 1998", "alternative": null, "alt_note": "", "outcome": "colorectal/colon"}, {"study": "willett1990", "class": "inclusion", "text": "NHS 1980–86 (150 colon cases); the report cites Wei 2004 (NHS+HPFS to 2000, 1,139 colon + 339 rectal cases, ref 19) but used it only in the HvL plot. Wei's continuous estimate cannot substitute: its printed unit (per week) contradicts the paper's Methods (per day) and the row is 'disputed' (rettelogg R15)", "page": "SER refs 9, 19; SLR 2010 Table 37", "alternative": "remove", "alt_note": "superseded cohort; no usable continuous row in Wei 2004", "outcome": "colorectal/colon"}, {"study": "giovannucci1994", "class": "inclusion", "text": "HPFS 1986–92 (205 colon cases); superseded by Wei 2004 (same cohort), which the report cites", "page": "SER refs 10, 19", "alternative": "remove", "alt_note": "superseded cohort", "outcome": "colorectal/colon"}, {"study": "singh1998", "class": "dose", "text": "4.51 (0.38–53.27) per time/week from a never / <1 / ≥1 time per week scale; the top category is open (≥1/week)", "page": "Singh 1998 Table 3", "alternative": null, "alt_note": "", "outcome": "colorectal/colon"}, {"study": "bostick1994", "class": "transcription", "text": "0.96 (0.80–1.14) per time/week has a CI four to five times narrower (log width 0.35) than a GL slope from Bostick's four categories, three above the reference (212 cases) can give (0.94; 0.43–2.04 per 100 g); cannot be checked without the 2005 SLR (called the 2006 SLR in the protocol)", "page": "Fig 4.3.2; Bostick 1994 Table 3", "alternative": null, "alt_note": "", "outcome": "colorectal/colon"}, {"study": "pietinen1999", "class": "exposure", "text": "Fig 4.3.3's 1.05 (0.74–1.48) is ATBC red meat including processed meat (Pietinen 1999 Table 5, multivariate): GL from those categories gives 1.05 (0.74–1.49). The paper's red meat row without processed meat (beef, pork, lamb; the row CUP 2010 and 2016 used) gives 0.83 (0.43–1.61)", "page": "SER Fig 4.3.3 p121; Pietinen 1999 Table 5; derived_per100g.csv", "alternative": [0.8338, 0.4313, 1.6119], "alt_note": "unprocessed red meat, GL (R105)", "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"}, {"study": "larsson2005", "class": "exposure", "text": "Fig 4.3.3's 1.43 (1.05–[0.95]) is SMC total red meat including processed meat (bacon, sausage, ham/cold cuts, blood pudding): GL from those categories gives 1.43 (1.05–1.95), which also confirms that the misprinted upper limit should be about 1.95. The paper's unprocessed 'red meat as main dish' row with CUP's 120 g/serving gives 1.23 (0.90–1.67)", "page": "SER Fig 4.3.3 p121; Larsson 2005 Table I; derived_per100g.csv", "alternative": [1.2252, 0.8978, 1.6721], "alt_note": "unprocessed red meat as main dish, GL with 120 g/serving (R105)", "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"}, {"study": "norat2005", "class": "model", "text": "Norat's 1.49 (0.91–2.43) is EPIC's measurement-error-calibrated estimate for fresh red meat; the observed estimate is 1.21 (1.02–1.43) (the value CUP 2010/2016 used). Shown as a model choice, not corrected", "page": "SER Fig 4.3.3; Norat 2005 Table 4", "alternative": [1.21, 1.02, 1.43], "alt_note": "observed estimate", "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"}], "notes": ["R105 (2.11.2026): Fig 4.3.3's Pietinen and Larsson values are reproduced within rounding from the papers' total red meat rows (incl. processed; Pietinen's upper limit 1.49 vs printed 1.48): 1.0523 and 1.4326 (1.054–1.947). Not registered as deviations before K27a.", "Fig 4.3.3 (per 100 g/day, 3 studies): Larsson 2005 is printed '1.43 (1.05–0.95)' in the report itself (PDF excerpt supplied by the author). Reading the upper limit off the forest plot (≈1.94) reproduces the figure's summary as a fixed-effect pool and the text's as random effects; SLR 2010 Table 36's 1.29 (0.94–1.78) remains unexplained. Norat's 1.49 is EPIC's *calibrated* estimate. The HvL plot (Fig 4.3.1) has no summary; Fig 4.3.4 is a line graph without values. The 2006 SLR is not on disk; per-study weights and case numbers are not printed."]}, "norat2002": {"id": "norat2002", "title": "Norat et al. 2002 (Int J Cancer 98:241): red meat, cohort studies, highest vs lowest (Table I: 1.27 (1.11–1.45), n = 9) and per 120 g/day (Table II: 1.22 (1.05–1.41), n = 9)", "runs": [{"name": "HvL – Appendix III values for the 9 cohorts named in Fig 2 (8 with CIs)", "k": 8, "re": [1.3782480890908402, 1.1553190326195328, 1.6441932846683347], "fe": [1.3782480890908402, 1.1553190326195328, 1.6441932846683347], "I2": 0.0, "Q": 5.404895435002658, "tau2": 0.0, "published": [1.27, 1.11, 1.45], "comment": "Thun 1992 has no CI in Appendix III; Fig 2 plots it with one. Pooling the printed values does not give the published 1.27: Norat's per-study inputs are not printed.", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 13.190200869335575, "note": "Appendix III: >=134 vs <59 (g/day)"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 10.504451400668179, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 1.71, "lo": 1.15, "hi": 2.55, "w": 19.635862583908636, "note": "Appendix III: 129.5 vs 18.5 g/day (red meat)"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 11.438734179097496, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 8.894952279150075, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 15.429207110287669, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 0.9, "hi": 4.3, "w": 5.090703131520239, "note": "Appendix III: >=60 vs <15 times/month (red meat)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 15.815888446032137, "note": "Appendix III: 203 vs 79 g/day (red meat)"}], "loo": {"willett1990": [1.3268424129932355, 1.0979391462158645, 1.60346845723231], "chen1998": [1.4050040188985957, 1.1659499617325073, 1.6930711933708946], "giovannucci1994": [1.3074971421118153, 1.073903299378508, 1.591901968845723], "bostick1994": [1.4292991064615448, 1.1849481414751513, 1.7240382631332314], "kato1997": [1.3936467159710846, 1.1584404103695831, 1.6766086123647417], "singh1998": [1.3725328314448706, 1.132922271016155, 1.6628204966827864], "hsing1998": [1.3547180512581283, 1.1303040562501574, 1.6236878813769762], "pietinen1999": [1.4378932631527124, 1.186350120151122, 1.742771380135726]}, "reproduced": false}, {"name": "HvL – the same 8 + Thun 1992 read off Fig 2 (pixel reading by controller K11, not printed)", "k": 9, "re": [1.2689509941150563, 1.1113886453598962, 1.4488510677056212], "fe": [1.2689509941150563, 1.1113886453598962, 1.4488510677056212], "I2": 0.0, "Q": 7.33988751269177, "tau2": 0.0, "published": [1.27, 1.11, 1.45], "comment": "With Thun's plotted entry (≈1.14, 0.93–1.39) the 9-cohort pool reproduces the published value exactly. The entry is read from figure pixels, not printed; the two sex-specific Thun values in Appendix III have no CIs.", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 7.44786411257665, "note": "Appendix III: >=134 vs <59 (g/day)"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 5.9313521745695, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 1.71, "lo": 1.15, "hi": 2.55, "w": 11.087415400789611, "note": "Appendix III: 129.5 vs 18.5 g/day (red meat)"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 6.458896163125348, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 5.022546397832139, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 8.712121904782833, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 0.9, "hi": 4.3, "w": 2.8744721582804096, "note": "Appendix III: >=60 vs <15 times/month (red meat)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 8.930462024999631, "note": "Appendix III: 203 vs 79 g/day (red meat)"}, {"label": "thun1992", "cohort": "cps2", "rr": 1.14, "lo": 0.93, "hi": 1.39, "w": 43.53486966304388, "note": "Fig 2 p245: single combined CPS-II entry, read from the rendered figure (low confidence)"}], "loo": {"willett1990": [1.2354191988122412, 1.0763748123222134, 1.417963872176705], "chen1998": [1.2829446364257122, 1.1127505177757118, 1.4791697814022164], "giovannucci1994": [1.2226151828848162, 1.0622488821002745, 1.4071917707882011], "bostick1994": [1.286504936531611, 1.1217029601697535, 1.4755198216377445], "kato1997": [1.2800599046912655, 1.1093203464911179, 1.477078613748595], "singh1998": [1.259366443223782, 1.0932227879178371, 1.4507599510789913], "hsing1998": [1.253881548985656, 1.096053600832073, 1.4344361787535869], "pietinen1999": [1.286855581040846, 1.1199374736742138, 1.4786515545578554], "thun1992": [1.3782480890908402, 1.1553190326195328, 1.6441932846683347]}, "reproduced": true}, {"name": "HvL – the same contrasts read from the primary papers (database; Thun, Hsing not in database)", "k": 7, "re": [1.3547180512581283, 1.1303040562501574, 1.6236878813769762], "fe": [1.3547180512581283, 1.1303040562501574, 1.6236878813769762], "I2": 0.0, "Q": 4.722701767756231, "tau2": 0.0, "published": null, "comment": "Transcription check of Appendix III: identical to the Appendix values for all 7 cohorts we hold.", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 13.897691063514936, "note": "paper: red_total Q5 >=134 vs lowest (colon, Age-adjusted, energy-adjusted )"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, 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"willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 9.6798113800632, "note": "Appendix III: >=134 vs <59 (g/day)"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 8.081147902905297, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 1.71, "lo": 1.15, "hi": 2.55, "w": 12.975371118462492, "note": "Appendix III: 129.5 vs 18.5 g/day (red meat)"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 8.654495789785326, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 7.046906955776891, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 10.904130434973466, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "hsing1998", "cohort": "hsing1998", "rr": 1.9, "lo": 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1.4786515545578554], "thun1992": [1.3075248888415936, 1.0559068691163287, 1.6191023895610943]}}, {"name": "HvL (Norat's 9-cohort set) – corrected: inclusion", "k": 7, "re": [1.3547180512581283, 1.1303040562501574, 1.6236878813769762], "fe": [1.3547180512581283, 1.1303040562501574, 1.6236878813769762], "I2": 0.0, "Q": 4.722701767756231, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 13.897691063514936, "note": "Appendix III: >=134 vs <59 (g/day)"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 11.067884545836101, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 1.71, "lo": 1.15, "hi": 2.55, "w": 20.689082346821056, "note": "Appendix III: 129.5 vs 18.5 g/day (red meat)"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 12.052279973108096, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 9.372055818173667, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 16.25679213667407, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 1.1, "lo": 0.7, "hi": 1.7, "w": 16.664214115872074, "note": "Appendix III: 203 vs 79 g/day (red meat)"}], "loo": {"willett1990": [1.2974941188983162, 1.0674349297321668, 1.577136874280597], "chen1998": [1.379659727803196, 1.138590328201789, 1.6717698344831224], "giovannucci1994": [1.274863286916992, 1.040267405529968, 1.5623640534048968], "bostick1994": [1.4046985880889045, 1.1580123098640942, 1.7039353611107437], "kato1997": [1.3683160733869766, 1.1312691612590247, 1.6550339572639152], "singh1998": [1.344240262446867, 1.102877495160419, 1.6384248396694205], "pietinen1999": [1.412332554165668, 1.1581838401973614, 1.722250971155161]}}, {"name": "HvL (Norat's 9-cohort set) – corrected: all classes", "k": 7, "re": [1.274408274317236, 1.018352379595065, 1.5948472082856477], "fe": [1.2819556996954131, 1.0700329656952305, 1.535850266924988], "I2": 33.91962627010204, "Q": 9.07985179461131, "tau2": 0.030871260437264555, "published": null, "comment": "", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 1.77, "lo": 1.09, "hi": 2.88, "w": 14.18750751298449, "note": "Appendix III: >=134 vs <59 (g/day)"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 12.124318874323341, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 1.71, "lo": 1.15, "hi": 2.55, "w": 18.153680796806707, "note": "Appendix III: 129.5 vs 18.5 g/day (red meat)"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 12.875387146930725, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 10.736794824454764, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 15.704275161042029, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 16.218035683457945, "note": "exposure: unprocessed red meat Q4 vs Q1"}], "loo": {"willett1990": [1.2081726654908023, 0.9555996219171021, 1.5275028957323897], "chen1998": [1.2878137156289151, 0.9939088243778715, 1.6686280728013991], "giovannucci1994": [1.1929003962938562, 0.944781477183598, 1.5061804129776644], "bostick1994": [1.3123856264754759, 1.0199793254516296, 1.688618572554691], "kato1997": [1.277979164250921, 0.9879446500489678, 1.6531601686172714], "singh1998": [1.2485598054002995, 0.956780346841932, 1.62932024346731], "pietinen1999": [1.412332554165668, 1.1581838401973614, 1.722250971155161]}}, {"name": "HvL – corrected + follow-ups", "k": 7, "re": [1.0143970407292424, 0.8841997190989146, 1.1637657579091933], "fe": [1.0143970407292424, 0.8841997190989146, 1.1637657579091933], "I2": 0.0, "Q": 4.157023585077593, "tau2": 0.0, "published": null, "comment": "", "rows": [{"label": "willett1990", "cohort": "nhs", "rr": 0.96, "lo": 0.76, "hi": 1.21, "w": 34.898775090783545, "note": "follow-up: NHS → Bernstein 2015 women >1 svg/d vs lowest, unprocessed red meat"}, {"label": "chen1998", "cohort": "phs", "rr": 1.17, "lo": 0.68, "hi": 2.02, "w": 6.367348657569082, "note": "Appendix III: >1 vs <=0.5 servings/day (red meat)"}, {"label": "giovannucci1994", "cohort": "hpfs", "rr": 0.98, "lo": 0.75, "hi": 1.27, "w": 27.208086267536334, "note": "follow-up: HPFS → Bernstein 2015 men >1 svg/d vs lowest, unprocessed red meat"}, {"label": "bostick1994", "cohort": "iwhs", "rr": 1.04, "lo": 0.62, "hi": 1.76, "w": 6.933670873562524, "note": "Appendix III: >11 vs <4 servings/week (red meat)"}, {"label": "kato1997", "cohort": "nyuwhs", "rr": 1.23, "lo": 0.68, "hi": 2.22, "w": 5.391739205931747, "note": "Appendix III: Q4 vs Q1 (red meat)"}, {"label": "singh1998", "cohort": "ahs", "rr": 1.41, "lo": 0.9, "hi": 2.21, "w": 9.352524699652221, "note": "Appendix III: >=1 time/week vs never (red meat)"}, {"label": "pietinen1999", "cohort": "atbc", "rr": 0.8, "lo": 0.5, "hi": 1.2, "w": 9.847855204964548, "note": "exposure: unprocessed red meat Q4 vs Q1"}], "loo": {"willett1990": [1.0448157913670484, 0.8812540603360841, 1.2387347610899317], "chen1998": [1.004600198961602, 0.8716468328240835, 1.1578331059654896], "giovannucci1994": [1.0275616605444822, 0.8747505447027161, 1.2070675149791135], "bostick1994": [1.0125149797861464, 0.8781353400514051, 1.1674585198123641], "kato1997": [1.003316745950156, 0.8711723152236475, 1.1555056044745684], "singh1998": [0.9805118447266762, 0.8487762122768593, 1.1326937109492328], "pietinen1999": [1.0410513815607718, 0.9008253886960113, 1.2031054993004004]}}], "deviations": [{"study": "pietinen1999", "class": "exposure", "text": "Norat's ATBC row (203 vs 79 g/day) is red meat including processed (Pietinen Table 5); the paper's red meat (beef, pork, lamb) row 99 vs 35 g/day gives 0.8 (0.5–1.2)", "page": "Pietinen 1999 Table 5; Chan 2011 S1", "alternative": [0.8, 0.5, 1.2], "alt_note": "unprocessed red meat Q4 vs Q1", "outcome": "colon/colorectal"}, {"study": "hsing1998", "class": "inclusion", "text": "fatal colorectal cancer only (Lutheran Brotherhood mortality cohort)", "page": "Hsing 1998", "alternative": "remove", "alt_note": "mortality", "outcome": "colon/colorectal"}, {"study": "chen1998", "class": "inclusion", "text": "nested case-control (Physicians' Health Study)", "page": "Chen 1998", "alternative": null, "alt_note": "", "outcome": "colon/colorectal"}, {"study": "giovannucci1994", "class": "exposure", "text": "HPFS 'red meat' here is total red meat including processed (Giovannucci Table 2, beef/pork/lamb + processed)", "page": "Giovannucci 1994 Table 2", "alternative": null, "alt_note": "", "outcome": "colon/colorectal"}, {"study": "willett1990", "class": "exposure", "text": "NHS 'red meat' quintiles (g/day) include processed meat", "page": "Willett 1990 Table 4 p1668", "alternative": null, "alt_note": "", "outcome": "colon/colorectal"}, {"study": "thun1992", "class": "inclusion", "text": "CPS-II mortality cohort (fatal colon cancer); value read off Fig 2, not printed", "page": "Thun 1992; Norat Fig 2", "alternative": "remove", "alt_note": "mortality; figure-read", "outcome": "colon/colorectal"}, {"study": "thun1992", "class": "transcription", "text": "Thun 1992 prints quintile-5 'fatty meats' RRs of 1.21 (men) and 1.05 (women) with NO confidence intervals (Table 4, unadjusted, conditional logistic); the single entry plotted in Norat's Fig 2 (≈1.14, 0.91–1.38) with a CI is therefore Norat's own construction, from inputs the paper does not print", "page": "Thun 1992 Table 4 p1495; Norat Appendix III p255; Fig 2 p245", "alternative": null, "alt_note": "", "outcome": "colon/colorectal"}], "notes": ["Per-study values behind Fig 2 (HvL) and Fig 4 (per 120 g) are not printed; the cohort HvL stratum reproduces only with one value read off the figure (R3 not met strictly). Missing from the printed pool: thun1992."]}}