{
 "protocol": "PROTOKOLL_KOLON_R8.md v1.0 incl. change log 2026-10-30 18:20 EDT",
 "inventory": "kontroll/kolon2026/INVENTAR.md",
 "cohorts": [
  {
   "key": "MCCS (English 2004)",
   "region": "Australia",
   "women_only": false,
   "year_site_publication": 2004,
   "colon_mode": "direct",
   "note": "fresh red meat; per serving/week x 5.833 (120 g/serving); subsites 'data not shown' (147 proximal, 111 distal)",
   "cases": {
    "colon": 283,
    "rectum": 169,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 1.0,
     "lo": 0.697,
     "hi": 1.4839,
     "prov": "english2004_010 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]",
     "where": "Table 3, 1512"
    },
    "rectum": {
     "rr": 1.5666,
     "lo": 0.9431,
     "hi": 2.3769,
     "prov": "english2004_015 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]",
     "where": "Table 3, 1512"
    }
   }
  },
  {
   "key": "EPIC (Norat 2005)",
   "region": "Europe",
   "women_only": false,
   "year_site_publication": 2005,
   "colon_mode": "direct",
   "note": "R8.1 substitution: colorectal row is Papadimitriou 2022 (no red-meat site analysis); observed (not calibrated) per 100 g; right/left colon = sensitivity only (change log 3)",
   "cases": {
    "colon": 855,
    "rectum": 474,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 1.2,
     "lo": 0.96,
     "hi": 1.48,
     "prov": "norat2005_033 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    },
    "rectum": {
     "rr": 1.23,
     "lo": 0.94,
     "hi": 1.62,
     "prov": "norat2005_035 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    }
   }
  },
  {
   "key": "SMC (Larsson 2005)",
   "region": "Europe",
   "women_only": true,
   "year_site_publication": 2005,
   "colon_mode": "constructed (R8.3)",
   "note": "beef/pork as main dish; GL with CUP dose rule (paper medians x 120 g); per-category site cases not printed (site totals split proportional to RR)",
   "cases": {
    "colon": 389,
    "rectum": 230,
    "proximal_colon": 234,
    "distal_colon": 155
   },
   "rows": {
    "colon": {
     "rr": 1.6799,
     "lo": 1.109,
     "hi": 2.5447,
     "prov": "larsson2005_037;larsson2005_038;larsson2005_039;larsson2005_040 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 234 (Table II) split proportional to RR]; larsson2005_041;larsson2005_042;larsson2005_043;larsson2005_044 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 155 (Table II) split proportional to RR] [R8.3: proximal + distal combined, fixed]",
     "where": "Table II, 831"
    },
    "rectum": {
     "rr": 0.9782,
     "lo": 0.555,
     "hi": 1.7244,
     "prov": "larsson2005_045;larsson2005_046;larsson2005_047;larsson2005_048 [GL_categories; conversion:cup:paper_median]",
     "where": "Table II, 831"
    },
    "proximal_colon": {
     "rr": 1.1676,
     "lo": 0.6648,
     "hi": 2.0507,
     "prov": "larsson2005_037;larsson2005_038;larsson2005_039;larsson2005_040 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 234 (Table II) split proportional to RR]",
     "where": "Table II, 831"
    },
    "distal_colon": {
     "rr": 2.5912,
     "lo": 1.4012,
     "hi": 4.7916,
     "prov": "larsson2005_041;larsson2005_042;larsson2005_043;larsson2005_044 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 155 (Table II) split proportional to RR]",
     "where": "Table II, 831"
    }
   }
  },
  {
   "key": "NLCS (Gilsing 2015)",
   "region": "Europe",
   "women_only": false,
   "year_site_publication": 2015,
   "colon_mode": "direct",
   "note": "fresh red meat; per 50 g -> ^2; case-cohort; subsites 'data not shown'",
   "cases": {
    "colon": 307,
    "rectum": 92,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 0.9409,
     "lo": 0.7396,
     "hi": 1.21,
     "prov": "gilsing2015_128 [continuous_scaled; per_50g]",
     "where": "Table 4, Sci Rep 5:13484 (PMC text)"
    },
    "rectum": {
     "rr": 0.9025,
     "lo": 0.5625,
     "hi": 1.4161,
     "prov": "gilsing2015_138 [continuous_scaled; per_50g]",
     "where": "Table 4, Sci Rep 5:13484 (PMC text)"
    }
   }
  },
  {
   "key": "JPHC + Takayama (Islam 2019)",
   "region": "Asia",
   "women_only": false,
   "year_site_publication": 2019,
   "colon_mode": "direct",
   "note": "per 100 g; sex strata (Tables 4/5) combined, fixed; case counts from Suppl. S3/S4 (change log 4; n_cases empty in estimates.csv)",
   "cases": {
    "colon": 2552,
    "rectum": 1127,
    "proximal_colon": 1200,
    "distal_colon": 1150
   },
   "rows": {
    "colon": {
     "rr": 1.0507,
     "lo": 0.8778,
     "hi": 1.2575,
     "prov": "islam2019_174 [continuous_scaled; per_100g]; islam2019_299 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    "rectum": {
     "rr": 1.2691,
     "lo": 0.9026,
     "hi": 1.7844,
     "prov": "islam2019_199 [continuous_scaled; per_100g]; islam2019_324 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    "proximal_colon": {
     "rr": 0.7973,
     "lo": 0.6192,
     "hi": 1.0267,
     "prov": "islam2019_224 [continuous_scaled; per_100g]; islam2019_349 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    "distal_colon": {
     "rr": 1.1485,
     "lo": 0.9462,
     "hi": 1.3941,
     "prov": "islam2019_249 [continuous_scaled; per_100g]; islam2019_374 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    }
   }
  },
  {
   "key": "UK Biobank (Knuppel 2020)",
   "region": "Europe",
   "women_only": false,
   "year_site_publication": 2020,
   "colon_mode": "direct",
   "note": "GL from category means, model 2 (Suppl. S5); proximal/distal only in Bradbury 2020 (different follow-up; sensitivity only, change log 2)",
   "cases": {
    "colon": 2114,
    "rectum": 1109,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 1.8649,
     "lo": 1.2725,
     "hi": 2.7331,
     "prov": "knuppel2020_116;knuppel2020_117;knuppel2020_118;knuppel2020_119 [GL_categories; paper_dose_point]",
     "where": "Suppl Table S5, suppl p. 19"
    },
    "rectum": {
     "rr": 0.9697,
     "lo": 0.5853,
     "hi": 1.6066,
     "prov": "knuppel2020_131;knuppel2020_132;knuppel2020_133;knuppel2020_134 [GL_categories; paper_dose_point]",
     "where": "Suppl Table S5, suppl p. 19"
    }
   }
  },
  {
   "key": "Sister Study (Mehta 2020)",
   "region": "N America",
   "women_only": true,
   "year_site_publication": 2020,
   "colon_mode": "direct",
   "note": "per 50 g -> ^2; subsites not analysed (few cases)",
   "cases": {
    "colon": 116,
    "rectum": 30,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 1.2321,
     "lo": 0.6241,
     "hi": 2.4649,
     "prov": "mehta2020_235 [continuous_scaled; per_50g]",
     "where": "Suppl Table 1, suppl"
    },
    "rectum": {
     "rr": 1.6129,
     "lo": 0.4489,
     "hi": 5.7121,
     "prov": "mehta2020_240 [continuous_scaled; per_50g]",
     "where": "Suppl Table 1, suppl"
    }
   }
  },
  {
   "key": "NIH-AARP (Zouiouich 2025)",
   "region": "N America",
   "women_only": false,
   "year_site_publication": 2025,
   "colon_mode": "constructed (R8.3)",
   "note": "addition model, per 50 g/1000 kcal = per 100 g/day at 2000 kcal/day (same assumption as the colorectal row); colon NOS (C18.8-18.9) in neither subsite",
   "cases": {
    "colon": 7002,
    "rectum": 2208,
    "proximal_colon": 4565,
    "distal_colon": 2437
   },
   "rows": {
    "colon": {
     "rr": 1.1314,
     "lo": 1.0509,
     "hi": 1.218,
     "prov": "zouiouich2025_142; zouiouich2025_182 [R8.3: proximal + distal combined, fixed]",
     "where": "Fig 2, 6"
    },
    "rectum": {
     "rr": 1.14,
     "lo": 1.0,
     "hi": 1.29,
     "prov": "zouiouich2025_214",
     "where": "Fig 2, 6"
    },
    "proximal_colon": {
     "rr": 1.09,
     "lo": 0.99,
     "hi": 1.19,
     "prov": "zouiouich2025_142",
     "where": "Fig 2, 6"
    },
    "distal_colon": {
     "rr": 1.21,
     "lo": 1.07,
     "hi": 1.37,
     "prov": "zouiouich2025_182",
     "where": "Fig 2, 6"
    }
   }
  },
  {
   "key": "NHS + HPFS (Bernstein 2015)",
   "region": "N America",
   "women_only": false,
   "year_site_publication": 2015,
   "colon_mode": "direct",
   "note": "Suppl. S5 per 100 g (unprocessed incl. hamburger); colon cases not printed (>= 1151 + 816); distal 816 in main text vs 817 (S3 + S4)",
   "cases": {
    "colon": null,
    "rectum": 589,
    "proximal_colon": 1151,
    "distal_colon": 817
   },
   "rows": {
    "colon": {
     "rr": 0.99,
     "lo": 0.87,
     "hi": 1.12,
     "prov": "bernstein2015_494 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    "rectum": {
     "rr": 1.08,
     "lo": 0.86,
     "hi": 1.35,
     "prov": "bernstein2015_512 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    "proximal_colon": {
     "rr": 1.12,
     "lo": 0.94,
     "hi": 1.32,
     "prov": "bernstein2015_500 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    "distal_colon": {
     "rr": 0.79,
     "lo": 0.65,
     "hi": 0.97,
     "prov": "bernstein2015_506 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    }
   }
  },
  {
   "key": "SWHS (Lee 2009)",
   "region": "Asia",
   "women_only": true,
   "year_site_publication": 2009,
   "colon_mode": "direct",
   "note": "CUP 2016's extraction (as the colorectal row); red meat undefined (mainly pork), lowest rung of the R8.1 hierarchy; own GL not possible (Q2-Q4 CIs not printed)",
   "cases": {
    "colon": 236,
    "rectum": 158,
    "proximal_colon": null,
    "distal_colon": null
   },
   "rows": {
    "colon": {
     "rr": 0.86,
     "lo": 0.43,
     "hi": 1.74,
     "prov": "CUP 2016 cup2016_lee2009_colon (SLR 2016 F132)",
     "where": "SLR 2016 F132"
    },
    "rectum": {
     "rr": 0.74,
     "lo": 0.33,
     "hi": 1.66,
     "prov": "CUP 2016 cup2016_lee2009_rectum (SLR 2016 F139)",
     "where": "SLR 2016 F139"
    }
   }
  },
  {
   "key": "BWHS (Yiannakou 2022)",
   "region": "N America",
   "women_only": true,
   "year_site_publication": 2022,
   "colon_mode": "constructed (R8.3)",
   "note": "GL from tertiles (85 g serving, CUP midpoint rule); unprocessed, partial (incl. 'dinner ham'); log10 slope not usable",
   "cases": {
    "colon": 314,
    "rectum": 104,
    "proximal_colon": 222,
    "distal_colon": 92
   },
   "rows": {
    "colon": {
     "rr": 0.7416,
     "lo": 0.3048,
     "hi": 1.8043,
     "prov": "yiannakou2022_061;yiannakou2022_062;yiannakou2022_063 [GL_categories; conversion:paper:cup_rule]; yiannakou2022_065;yiannakou2022_066;yiannakou2022_067 [GL_categories; conversion:paper:cup_rule] [R8.3: proximal + distal combined, fixed]",
     "where": "Table 3, 1258"
    },
    "rectum": {
     "rr": 3.1225,
     "lo": 0.6166,
     "hi": 15.8137,
     "prov": "yiannakou2022_069;yiannakou2022_070;yiannakou2022_071 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    },
    "proximal_colon": {
     "rr": 0.5813,
     "lo": 0.2023,
     "hi": 1.6702,
     "prov": "yiannakou2022_061;yiannakou2022_062;yiannakou2022_063 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    },
    "distal_colon": {
     "rr": 1.345,
     "lo": 0.2582,
     "hi": 7.0074,
     "prov": "yiannakou2022_065;yiannakou2022_066;yiannakou2022_067 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    }
   }
  }
 ],
 "main": {
  "colon": {
   "k": 11,
   "re": [
    1.1125,
    1.0058,
    1.2306
   ],
   "fe": [
    1.1034,
    1.0452,
    1.1649
   ],
   "I2": 46.0599,
   "tau2": 0.0099,
   "Q": 18.5391,
   "pQ": 0.0465,
   "logrr": 0.1066,
   "se": 0.0514,
   "reml": [
    1.1119,
    1.0066,
    1.2283
   ],
   "tau2_reml": 0.0095,
   "hksj": [
    1.1125,
    0.9775,
    1.2663
   ],
   "loo": {
    "MCCS (English 2004)": [
     1.1217,
     1.0073,
     1.249
    ],
    "EPIC (Norat 2005)": [
     1.1035,
     0.9857,
     1.2355
    ],
    "SMC (Larsson 2005)": [
     1.0881,
     0.9916,
     1.194
    ],
    "NLCS (Gilsing 2015)": [
     1.1345,
     1.0194,
     1.2625
    ],
    "JPHC + Takayama (Islam 2019)": [
     1.1275,
     1.0025,
     1.2682
    ],
    "UK Biobank (Knuppel 2020)": [
     1.081,
     1.0026,
     1.1656
    ],
    "Sister Study (Mehta 2020)": [
     1.1116,
     1.0007,
     1.2348
    ],
    "NIH-AARP (Zouiouich 2025)": [
     1.1188,
     0.9779,
     1.28
    ],
    "NHS + HPFS (Bernstein 2015)": [
     1.1437,
     1.0207,
     1.2814
    ],
    "SWHS (Lee 2009)": [
     1.1193,
     1.0089,
     1.2418
    ],
    "BWHS (Yiannakou 2022)": [
     1.1187,
     1.0098,
     1.2393
    ]
   },
   "egger": {
    "intercept": 0.1916,
    "p": 0.7849
   },
   "rows": [
    {
     "key": "MCCS (English 2004)",
     "rr": 1.0,
     "lo": 0.697,
     "hi": 1.4839,
     "w_re": 5.6215,
     "cohort": "mccs",
     "prov": "english2004_010 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]",
     "where": "Table 3, 1512"
    },
    {
     "key": "EPIC (Norat 2005)",
     "rr": 1.2,
     "lo": 0.96,
     "hi": 1.48,
     "w_re": 11.9695,
     "cohort": "epic",
     "prov": "norat2005_033 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    },
    {
     "key": "SMC (Larsson 2005)",
     "rr": 1.6799,
     "lo": 1.109,
     "hi": 2.5447,
     "w_re": 4.8281,
     "cohort": "smc",
     "prov": "larsson2005_037;larsson2005_038;larsson2005_039;larsson2005_040 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 234 (Table II) split proportional to RR]; larsson2005_041;larsson2005_042;larsson2005_043;larsson2005_044 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 155 (Table II) split proportional to RR] [R8.3: proximal + distal combined, fixed]",
     "where": "Table II, 831"
    },
    {
     "key": "NLCS (Gilsing 2015)",
     "rr": 0.9409,
     "lo": 0.7396,
     "hi": 1.21,
     "w_re": 10.3029,
     "cohort": "nlcs",
     "prov": "gilsing2015_128 [continuous_scaled; per_50g]",
     "where": "Table 4, Sci Rep 5:13484 (PMC text)"
    },
    {
     "key": "JPHC + Takayama (Islam 2019)",
     "rr": 1.0507,
     "lo": 0.8778,
     "hi": 1.2575,
     "w_re": 14.4438,
     "cohort": "jphc",
     "prov": "islam2019_174 [continuous_scaled; per_100g]; islam2019_299 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    {
     "key": "UK Biobank (Knuppel 2020)",
     "rr": 1.8649,
     "lo": 1.2725,
     "hi": 2.7331,
     "w_re": 5.5194,
     "cohort": "ukbiobank",
     "prov": "knuppel2020_116;knuppel2020_117;knuppel2020_118;knuppel2020_119 [GL_categories; paper_dose_point]",
     "where": "Suppl Table S5, suppl p. 19"
    },
    {
     "key": "Sister Study (Mehta 2020)",
     "rr": 1.2321,
     "lo": 0.6241,
     "hi": 2.4649,
     "w_re": 1.9942,
     "cohort": "sister",
     "prov": "mehta2020_235 [continuous_scaled; per_50g]",
     "where": "Suppl Table 1, suppl"
    },
    {
     "key": "NIH-AARP (Zouiouich 2025)",
     "rr": 1.1314,
     "lo": 1.0509,
     "hi": 1.218,
     "w_re": 23.3513,
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_142; zouiouich2025_182 [R8.3: proximal + distal combined, fixed]",
     "where": "Fig 2, 6"
    },
    {
     "key": "NHS + HPFS (Bernstein 2015)",
     "rr": 0.99,
     "lo": 0.87,
     "hi": 1.12,
     "w_re": 18.8121,
     "cohort": "nhs_hpfs",
     "prov": "bernstein2015_494 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    {
     "key": "SWHS (Lee 2009)",
     "rr": 0.86,
     "lo": 0.43,
     "hi": 1.74,
     "w_re": 1.9305,
     "cohort": "lee2009",
     "prov": "CUP 2016 cup2016_lee2009_colon (SLR 2016 F132)",
     "where": "SLR 2016 F132"
    },
    {
     "key": "BWHS (Yiannakou 2022)",
     "rr": 0.7416,
     "lo": 0.3048,
     "hi": 1.8043,
     "w_re": 1.2266,
     "cohort": "bwhs",
     "prov": "yiannakou2022_061;yiannakou2022_062;yiannakou2022_063 [GL_categories; conversion:paper:cup_rule]; yiannakou2022_065;yiannakou2022_066;yiannakou2022_067 [GL_categories; conversion:paper:cup_rule] [R8.3: proximal + distal combined, fixed]",
     "where": "Table 3, 1258"
    }
   ]
  },
  "rectum": {
   "k": 11,
   "re": [
    1.1409,
    1.0423,
    1.2489
   ],
   "fe": [
    1.1409,
    1.0423,
    1.2489
   ],
   "I2": 0.0,
   "tau2": 0.0,
   "Q": 7.2438,
   "pQ": 0.7022,
   "logrr": 0.1319,
   "se": 0.0461,
   "reml": [
    1.1409,
    1.0423,
    1.2489
   ],
   "tau2_reml": 0.0,
   "hksj": [
    1.1409,
    1.0454,
    1.2452
   ],
   "loo": {
    "MCCS (English 2004)": [
     1.1267,
     1.0275,
     1.2354
    ],
    "EPIC (Norat 2005)": [
     1.1304,
     1.0271,
     1.244
    ],
    "SMC (Larsson 2005)": [
     1.1455,
     1.0453,
     1.2554
    ],
    "NLCS (Gilsing 2015)": [
     1.1517,
     1.0503,
     1.2629
    ],
    "JPHC + Takayama (Islam 2019)": [
     1.1318,
     1.0305,
     1.243
    ],
    "UK Biobank (Knuppel 2020)": [
     1.1471,
     1.0464,
     1.2575
    ],
    "Sister Study (Mehta 2020)": [
     1.1389,
     1.0403,
     1.247
    ],
    "NIH-AARP (Zouiouich 2025)": [
     1.1419,
     1.0044,
     1.2983
    ],
    "NHS + HPFS (Bernstein 2015)": [
     1.153,
     1.0447,
     1.2726
    ],
    "SWHS (Lee 2009)": [
     1.1472,
     1.0475,
     1.2565
    ],
    "BWHS (Yiannakou 2022)": [
     1.1374,
     1.0389,
     1.2451
    ]
   },
   "egger": {
    "intercept": 0.1429,
    "p": 0.7609
   },
   "rows": [
    {
     "key": "MCCS (English 2004)",
     "rr": 1.5666,
     "lo": 0.9431,
     "hi": 2.3769,
     "w_re": 3.8241,
     "cohort": "mccs",
     "prov": "english2004_015 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]",
     "where": "Table 3, 1512"
    },
    {
     "key": "EPIC (Norat 2005)",
     "rr": 1.23,
     "lo": 0.94,
     "hi": 1.62,
     "w_re": 11.0295,
     "cohort": "epic",
     "prov": "norat2005_035 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    },
    {
     "key": "SMC (Larsson 2005)",
     "rr": 0.9782,
     "lo": 0.555,
     "hi": 1.7244,
     "w_re": 2.5425,
     "cohort": "smc",
     "prov": "larsson2005_045;larsson2005_046;larsson2005_047;larsson2005_048 [GL_categories; conversion:cup:paper_median]",
     "where": "Table II, 831"
    },
    {
     "key": "NLCS (Gilsing 2015)",
     "rr": 0.9025,
     "lo": 0.5625,
     "hi": 1.4161,
     "w_re": 3.8333,
     "cohort": "nlcs",
     "prov": "gilsing2015_138 [continuous_scaled; per_50g]",
     "where": "Table 4, Sci Rep 5:13484 (PMC text)"
    },
    {
     "key": "JPHC + Takayama (Islam 2019)",
     "rr": 1.2691,
     "lo": 0.9026,
     "hi": 1.7844,
     "w_re": 7.0344,
     "cohort": "jphc",
     "prov": "islam2019_199 [continuous_scaled; per_100g]; islam2019_324 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    {
     "key": "UK Biobank (Knuppel 2020)",
     "rr": 0.9697,
     "lo": 0.5853,
     "hi": 1.6066,
     "w_re": 3.2048,
     "cohort": "ukbiobank",
     "prov": "knuppel2020_131;knuppel2020_132;knuppel2020_133;knuppel2020_134 [GL_categories; paper_dose_point]",
     "where": "Suppl Table S5, suppl p. 19"
    },
    {
     "key": "Sister Study (Mehta 2020)",
     "rr": 1.6129,
     "lo": 0.4489,
     "hi": 5.7121,
     "w_re": 0.5051,
     "cohort": "sister",
     "prov": "mehta2020_240 [continuous_scaled; per_50g]",
     "where": "Suppl Table 1, suppl"
    },
    {
     "key": "NIH-AARP (Zouiouich 2025)",
     "rr": 1.14,
     "lo": 1.0,
     "hi": 1.29,
     "w_re": 50.3935,
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_214",
     "where": "Fig 2, 6"
    },
    {
     "key": "NHS + HPFS (Bernstein 2015)",
     "rr": 1.08,
     "lo": 0.86,
     "hi": 1.35,
     "w_re": 16.0702,
     "cohort": "nhs_hpfs",
     "prov": "bernstein2015_512 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    {
     "key": "SWHS (Lee 2009)",
     "rr": 0.74,
     "lo": 0.33,
     "hi": 1.66,
     "w_re": 1.2521,
     "cohort": "lee2009",
     "prov": "CUP 2016 cup2016_lee2009_rectum (SLR 2016 F139)",
     "where": "SLR 2016 F139"
    },
    {
     "key": "BWHS (Yiannakou 2022)",
     "rr": 3.1225,
     "lo": 0.6166,
     "hi": 15.8137,
     "w_re": 0.3104,
     "cohort": "bwhs",
     "prov": "yiannakou2022_069;yiannakou2022_070;yiannakou2022_071 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    }
   ]
  },
  "proximal_colon": {
   "k": 5,
   "re": [
    1.0273,
    0.894,
    1.1805
   ],
   "fe": [
    1.0632,
    0.9853,
    1.1473
   ],
   "I2": 42.7165,
   "tau2": 0.0093,
   "Q": 6.9828,
   "pQ": 0.1368,
   "logrr": 0.0269,
   "se": 0.0709,
   "reml": [
    1.0207,
    0.8742,
    1.1918
   ],
   "tau2_reml": 0.0133,
   "hksj": [
    1.0273,
    0.834,
    1.2654
   ],
   "loo": {
    "SMC (Larsson 2005)": [
     1.012,
     0.8635,
     1.1859
    ],
    "JPHC + Takayama (Islam 2019)": [
     1.0941,
     1.0102,
     1.1851
    ],
    "NIH-AARP (Zouiouich 2025)": [
     0.9652,
     0.7512,
     1.2401
    ],
    "NHS + HPFS (Bernstein 2015)": [
     0.9645,
     0.7636,
     1.2183
    ],
    "BWHS (Yiannakou 2022)": [
     1.0384,
     0.9054,
     1.1909
    ]
   },
   "rows": [
    {
     "key": "SMC (Larsson 2005)",
     "rr": 1.1676,
     "lo": 0.6648,
     "hi": 2.0507,
     "w_re": 5.4728,
     "cohort": "smc",
     "prov": "larsson2005_037;larsson2005_038;larsson2005_039;larsson2005_040 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 234 (Table II) split proportional to RR]",
     "where": "Table II, 831"
    },
    {
     "key": "JPHC + Takayama (Islam 2019)",
     "rr": 0.7973,
     "lo": 0.6192,
     "hi": 1.0267,
     "w_re": 19.3667,
     "cohort": "jphc",
     "prov": "islam2019_224 [continuous_scaled; per_100g]; islam2019_349 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    {
     "key": "NIH-AARP (Zouiouich 2025)",
     "rr": 1.09,
     "lo": 0.99,
     "hi": 1.19,
     "w_re": 43.5999,
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_142",
     "where": "Fig 2, 6"
    },
    {
     "key": "NHS + HPFS (Bernstein 2015)",
     "rr": 1.12,
     "lo": 0.94,
     "hi": 1.32,
     "w_re": 29.8799,
     "cohort": "nhs_hpfs",
     "prov": "bernstein2015_500 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    {
     "key": "BWHS (Yiannakou 2022)",
     "rr": 0.5813,
     "lo": 0.2023,
     "hi": 1.6702,
     "w_re": 1.6806,
     "cohort": "bwhs",
     "prov": "yiannakou2022_061;yiannakou2022_062;yiannakou2022_063 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    }
   ]
  },
  "distal_colon": {
   "k": 5,
   "re": [
    1.1659,
    0.8905,
    1.5265
   ],
   "fe": [
    1.1135,
    1.0164,
    1.2199
   ],
   "I2": 80.4233,
   "tau2": 0.0584,
   "Q": 20.4325,
   "pQ": 0.0004,
   "logrr": 0.1535,
   "se": 0.1375,
   "reml": [
    1.2111,
    0.8351,
    1.7564
   ],
   "tau2_reml": 0.1273,
   "hksj": [
    1.1659,
    0.7216,
    1.8839
   ],
   "loo": {
    "SMC (Larsson 2005)": [
     1.0455,
     0.8236,
     1.3272
    ],
    "JPHC + Takayama (Islam 2019)": [
     1.2231,
     0.813,
     1.8398
    ],
    "NIH-AARP (Zouiouich 2025)": [
     1.2053,
     0.7896,
     1.84
    ],
    "NHS + HPFS (Bernstein 2015)": [
     1.2791,
     1.0365,
     1.5784
    ],
    "BWHS (Yiannakou 2022)": [
     1.1651,
     0.8806,
     1.5417
    ]
   },
   "rows": [
    {
     "key": "SMC (Larsson 2005)",
     "rr": 2.5912,
     "lo": 1.4012,
     "hi": 4.7916,
     "w_re": 12.0565,
     "cohort": "smc",
     "prov": "larsson2005_041;larsson2005_042;larsson2005_043;larsson2005_044 [GL_categories (pipeline K19 covariance); conversion:cup:paper_median; cases ASSUMED: site total 155 (Table II) split proportional to RR]",
     "where": "Table II, 831"
    },
    {
     "key": "JPHC + Takayama (Islam 2019)",
     "rr": 1.1485,
     "lo": 0.9462,
     "hi": 1.3941,
     "w_re": 27.7226,
     "cohort": "jphc",
     "prov": "islam2019_249 [continuous_scaled; per_100g]; islam2019_374 [continuous_scaled; per_100g] [strata combined, fixed]",
     "where": "Table 4, page not marked in txt; Table 5, page not marked in txt"
    },
    {
     "key": "NIH-AARP (Zouiouich 2025)",
     "rr": 1.21,
     "lo": 1.07,
     "hi": 1.37,
     "w_re": 30.2993,
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_182",
     "where": "Fig 2, 6"
    },
    {
     "key": "NHS + HPFS (Bernstein 2015)",
     "rr": 0.79,
     "lo": 0.65,
     "hi": 0.97,
     "w_re": 27.4588,
     "cohort": "nhs_hpfs",
     "prov": "bernstein2015_506 [continuous_scaled; per_100g]",
     "where": "Suppl Table S5, suppl"
    },
    {
     "key": "BWHS (Yiannakou 2022)",
     "rr": 1.345,
     "lo": 0.2582,
     "hi": 7.0074,
     "w_re": 2.4629,
     "cohort": "bwhs",
     "prov": "yiannakou2022_065;yiannakou2022_066;yiannakou2022_067 [GL_categories; conversion:paper:cup_rule]",
     "where": "Table 3, 1258"
    }
   ]
  }
 },
 "ratio_tests": {
  "colon / rectum": {
   "ratio": 0.9751,
   "lo": 0.8516,
   "hi": 1.1165,
   "z": -0.3651,
   "p": 0.7151,
   "k_num": 11,
   "k_den": 11
  },
  "proximal / distal": {
   "ratio": 0.8811,
   "lo": 0.6506,
   "hi": 1.1932,
   "z": -0.8182,
   "p": 0.4132,
   "k_num": 5,
   "k_den": 5
  },
  "rectum / proximal (supplementary, for R8.7)": {
   "ratio": 1.1106,
   "lo": 0.9409,
   "hi": 1.3109,
   "z": 1.2403,
   "p": 0.2149,
   "k_num": 11,
   "k_den": 5
  },
  "rectum / proximal, same 5 cohorts (supplementary, for R8.7)": {
   "ratio": 1.1069,
   "lo": 0.9308,
   "hi": 1.3164,
   "z": 1.1493,
   "p": 0.2505,
   "k_num": 5,
   "k_den": 5,
   "rectum_5": {
    "k": 5,
    "re": [
     1.1372,
     1.0254,
     1.2611
    ],
    "fe": [
     1.1372,
     1.0254,
     1.2611
    ],
    "reml": [
     1.1372,
     1.0254,
     1.2611
    ],
    "hksj": [
     1.1372,
     1.0161,
     1.2727
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 2.3615,
    "studies": [
     "SMC (Larsson 2005)",
     "JPHC + Takayama (Islam 2019)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)",
     "BWHS (Yiannakou 2022)"
    ]
   }
  },
  "_note": "Approximation: the two pooled log-RRs come largely from the same cohorts and participants and are treated as independent; positive within-cohort correlation (shared confounder adjustment, shared exposure measurement) would make the true CI of the ratio narrower, so these tests are conservative under that assumption. No within-cohort covariances are published."
 },
 "subgroups": {
  "colon": {
   "region: Europe": {
    "k": 4,
    "re": [
     1.3225,
     0.9883,
     1.7696
    ],
    "fe": [
     1.2229,
     1.0623,
     1.4076
    ],
    "reml": [
     1.3268,
     0.977,
     1.8018
    ],
    "hksj": [
     1.3225,
     0.805,
     2.1726
    ],
    "I2": 73.4844,
    "tau2": 0.0628,
    "Q": 11.3141,
    "studies": [
     "EPIC (Norat 2005)",
     "SMC (Larsson 2005)",
     "NLCS (Gilsing 2015)",
     "UK Biobank (Knuppel 2020)"
    ]
   },
   "region: N America": {
    "k": 4,
    "re": [
     1.074,
     0.9734,
     1.185
    ],
    "fe": [
     1.0925,
     1.0255,
     1.1639
    ],
    "reml": [
     1.0677,
     0.947,
     1.2039
    ],
    "hksj": [
     1.074,
     0.9306,
     1.2395
    ],
    "I2": 25.8637,
    "tau2": 0.0028,
    "Q": 4.0466,
    "studies": [
     "Sister Study (Mehta 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)",
     "BWHS (Yiannakou 2022)"
    ]
   },
   "region: Asia": {
    "k": 2,
    "skipped": "k < 3",
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "SWHS (Lee 2009)"
    ]
   },
   "women-only cohorts": {
    "k": 4,
    "re": [
     1.199,
     0.818,
     1.7575
    ],
    "fe": [
     1.279,
     0.949,
     1.7237
    ],
    "reml": [
     1.1897,
     0.8002,
     1.7688
    ],
    "hksj": [
     1.199,
     0.6603,
     2.1771
    ],
    "I2": 31.0232,
    "tau2": 0.048,
    "Q": 4.3493,
    "studies": [
     "SMC (Larsson 2005)",
     "Sister Study (Mehta 2020)",
     "SWHS (Lee 2009)",
     "BWHS (Yiannakou 2022)"
    ]
   },
   "mixed-sex cohorts": {
    "k": 7,
    "re": [
     1.097,
     0.9893,
     1.2163
    ],
    "fe": [
     1.0979,
     1.039,
     1.1601
    ],
    "reml": [
     1.0933,
     1.0008,
     1.1944
    ],
    "hksj": [
     1.097,
     0.9409,
     1.2789
    ],
    "I2": 54.6048,
    "tau2": 0.009,
    "Q": 13.2172,
    "studies": [
     "MCCS (English 2004)",
     "EPIC (Norat 2005)",
     "NLCS (Gilsing 2015)",
     "JPHC + Takayama (Islam 2019)",
     "UK Biobank (Knuppel 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)"
    ]
   },
   "published <= 2015": {
    "k": 6,
    "re": [
     1.0713,
     0.9281,
     1.2366
    ],
    "fe": [
     1.0439,
     0.9511,
     1.1457
    ],
    "reml": [
     1.069,
     0.9319,
     1.2263
    ],
    "hksj": [
     1.0713,
     0.8784,
     1.3065
    ],
    "I2": 40.0491,
    "tau2": 0.0117,
    "Q": 8.3402,
    "studies": [
     "MCCS (English 2004)",
     "EPIC (Norat 2005)",
     "SMC (Larsson 2005)",
     "NLCS (Gilsing 2015)",
     "NHS + HPFS (Bernstein 2015)",
     "SWHS (Lee 2009)"
    ]
   },
   "published > 2015": {
    "k": 5,
    "re": [
     1.1745,
     0.9906,
     1.3925
    ],
    "fe": [
     1.1353,
     1.062,
     1.2136
    ],
    "reml": [
     1.1905,
     0.9571,
     1.4809
    ],
    "hksj": [
     1.1745,
     0.8831,
     1.562
    ],
    "I2": 50.8316,
    "tau2": 0.0153,
    "Q": 8.1353,
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "UK Biobank (Knuppel 2020)",
     "Sister Study (Mehta 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "BWHS (Yiannakou 2022)"
    ]
   }
  },
  "rectum": {
   "region: Europe": {
    "k": 4,
    "re": [
     1.0878,
     0.8915,
     1.3275
    ],
    "fe": [
     1.0878,
     0.8915,
     1.3275
    ],
    "reml": [
     1.0878,
     0.8914,
     1.3275
    ],
    "hksj": [
     1.0878,
     0.8501,
     1.392
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 1.7454,
    "studies": [
     "EPIC (Norat 2005)",
     "SMC (Larsson 2005)",
     "NLCS (Gilsing 2015)",
     "UK Biobank (Knuppel 2020)"
    ]
   },
   "region: N America": {
    "k": 4,
    "re": [
     1.1336,
     1.0153,
     1.2656
    ],
    "fe": [
     1.1336,
     1.0153,
     1.2656
    ],
    "reml": [
     1.1336,
     1.0152,
     1.2657
    ],
    "hksj": [
     1.1336,
     0.9803,
     1.3109
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 1.9788,
    "studies": [
     "Sister Study (Mehta 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)",
     "BWHS (Yiannakou 2022)"
    ]
   },
   "region: Asia": {
    "k": 2,
    "skipped": "k < 3",
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "SWHS (Lee 2009)"
    ]
   },
   "women-only cohorts": {
    "k": 4,
    "re": [
     1.0357,
     0.6799,
     1.5778
    ],
    "fe": [
     1.0357,
     0.6799,
     1.5778
    ],
    "reml": [
     1.0357,
     0.6799,
     1.5779
    ],
    "hksj": [
     1.0357,
     0.526,
     2.0395
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 2.9482,
    "studies": [
     "SMC (Larsson 2005)",
     "Sister Study (Mehta 2020)",
     "SWHS (Lee 2009)",
     "BWHS (Yiannakou 2022)"
    ]
   },
   "mixed-sex cohorts": {
    "k": 7,
    "re": [
     1.1463,
     1.045,
     1.2574
    ],
    "fe": [
     1.1463,
     1.045,
     1.2574
    ],
    "reml": [
     1.1463,
     1.0449,
     1.2575
    ],
    "hksj": [
     1.1463,
     1.0421,
     1.2609
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 4.0828,
    "studies": [
     "MCCS (English 2004)",
     "EPIC (Norat 2005)",
     "NLCS (Gilsing 2015)",
     "JPHC + Takayama (Islam 2019)",
     "UK Biobank (Knuppel 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)"
    ]
   },
   "published <= 2015": {
    "k": 6,
    "re": [
     1.1212,
     0.9693,
     1.2969
    ],
    "fe": [
     1.1212,
     0.9693,
     1.2969
    ],
    "reml": [
     1.1212,
     0.9693,
     1.2969
    ],
    "hksj": [
     1.1212,
     0.9326,
     1.3479
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 4.6508,
    "studies": [
     "MCCS (English 2004)",
     "EPIC (Norat 2005)",
     "SMC (Larsson 2005)",
     "NLCS (Gilsing 2015)",
     "NHS + HPFS (Bernstein 2015)",
     "SWHS (Lee 2009)"
    ]
   },
   "published > 2015": {
    "k": 5,
    "re": [
     1.1535,
     1.0279,
     1.2945
    ],
    "fe": [
     1.1535,
     1.0279,
     1.2945
    ],
    "reml": [
     1.1535,
     1.0278,
     1.2946
    ],
    "hksj": [
     1.1535,
     1.0137,
     1.3126
    ],
    "I2": 0.0,
    "tau2": 0.0,
    "Q": 2.5031,
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "UK Biobank (Knuppel 2020)",
     "Sister Study (Mehta 2020)",
     "NIH-AARP (Zouiouich 2025)",
     "BWHS (Yiannakou 2022)"
    ]
   }
  },
  "proximal_colon": {
   "region: Europe": {
    "k": 1,
    "skipped": "k < 3",
    "studies": [
     "SMC (Larsson 2005)"
    ]
   },
   "region: N America": {
    "k": 3,
    "re": [
     1.0927,
     1.008,
     1.1845
    ],
    "fe": [
     1.0927,
     1.008,
     1.1845
    ],
    "reml": [
     1.0927,
     1.0079,
     1.1846
    ],
    "hksj": [
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     0.9394,
     1.271
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    "tau2": 0.0,
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   "region: Asia": {
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     "BWHS (Yiannakou 2022)"
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   "mixed-sex cohorts": {
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     0.8758,
     1.2004
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     0.9858,
     1.15
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    "reml": [
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     0.8532,
     1.2179
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    "hksj": [
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     0.6786,
     1.5493
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    "I2": 64.4019,
    "tau2": 0.0122,
    "Q": 5.6183,
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     "NHS + HPFS (Bernstein 2015)"
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     "NHS + HPFS (Bernstein 2015)"
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     0.6895,
     1.2353
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     0.9603,
     1.1409
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    "reml": [
     0.9225,
     0.6884,
     1.2363
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    "hksj": [
     0.9229,
     0.5112,
     1.6661
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    "I2": 68.6984,
    "tau2": 0.0391,
    "Q": 6.3894,
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "NIH-AARP (Zouiouich 2025)",
     "BWHS (Yiannakou 2022)"
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   }
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    "studies": [
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     0.6788,
     1.4771
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     0.9694,
     1.1958
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    "reml": [
     1.0011,
     0.6832,
     1.4671
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    "hksj": [
     1.0013,
     0.5152,
     1.9459
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    "I2": 84.2378,
    "tau2": 0.0758,
    "Q": 12.6886,
    "studies": [
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)",
     "BWHS (Yiannakou 2022)"
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   },
   "region: Asia": {
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    "studies": [
     "JPHC + Takayama (Islam 2019)"
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    "studies": [
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     "BWHS (Yiannakou 2022)"
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   "mixed-sex cohorts": {
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     1.0395,
     0.8088,
     1.336
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    "fe": [
     1.0918,
     0.9955,
     1.1976
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    "reml": [
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     0.8018,
     1.3465
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    "hksj": [
     1.0395,
     0.5864,
     1.8429
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    "I2": 84.5652,
    "tau2": 0.0413,
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    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "NIH-AARP (Zouiouich 2025)",
     "NHS + HPFS (Bernstein 2015)"
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   "published <= 2015": {
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     "NHS + HPFS (Bernstein 2015)"
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   "published > 2015": {
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     1.0747,
     1.3231
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     1.1925,
     1.0747,
     1.3231
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    "reml": [
     1.1925,
     1.0746,
     1.3232
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    "hksj": [
     1.1925,
     1.1058,
     1.2859
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    "I2": 0.0,
    "tau2": 0.0,
    "Q": 0.2183,
    "studies": [
     "JPHC + Takayama (Islam 2019)",
     "NIH-AARP (Zouiouich 2025)",
     "BWHS (Yiannakou 2022)"
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   }
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   "k": 8,
   "re": [
    1.0865,
    0.9572,
    1.2333
   ],
   "fe": [
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    0.9733,
    1.1463
   ],
   "reml": [
    1.0863,
    0.9573,
    1.2327
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   "hksj": [
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    0.9213,
    1.2813
   ],
   "I2": 43.0915,
   "tau2": 0.0124,
   "Q": 12.3004,
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    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "Sister Study (Mehta 2020)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)"
   ]
  },
  "colon: constructed from subsites only (R8.3)": {
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   "re": [
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    0.8849,
    1.6769
   ],
   "fe": [
    1.1418,
    1.0621,
    1.2276
   ],
   "reml": [
    1.2176,
    0.8925,
    1.6612
   ],
   "hksj": [
    1.2181,
    0.576,
    2.5762
   ],
   "I2": 53.3266,
   "tau2": 0.0435,
   "Q": 4.2851,
   "studies": [
    "SMC (Larsson 2005)",
    "NIH-AARP (Zouiouich 2025)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "proximal_colon: + UK Biobank (Bradbury 2020 Suppl. S9, GL)": {
   "k": 6,
   "re": [
    1.0376,
    0.9202,
    1.17
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   "fe": [
    1.0637,
    0.9863,
    1.1471
   ],
   "reml": [
    1.0292,
    0.8959,
    1.1823
   ],
   "hksj": [
    1.0376,
    0.8847,
    1.217
   ],
   "I2": 28.4976,
   "tau2": 0.0059,
   "Q": 6.9928,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)"
   ]
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  "distal_colon: + UK Biobank (Bradbury 2020 Suppl. S9, GL)": {
   "k": 6,
   "re": [
    1.2683,
    0.9655,
    1.666
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   "fe": [
    1.1303,
    1.0327,
    1.2371
   ],
   "reml": [
    1.341,
    0.916,
    1.9632
   ],
   "hksj": [
    1.2683,
    0.8044,
    1.9996
   ],
   "I2": 80.389,
   "tau2": 0.0696,
   "Q": 25.4959,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)"
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  "proximal_colon: + EPIC (Norat 2005 right side, GL)": {
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   "re": [
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    0.9246,
    1.1848
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   "fe": [
    1.0685,
    0.9914,
    1.1516
   ],
   "reml": [
    1.0443,
    0.9157,
    1.191
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   "hksj": [
    1.0467,
    0.883,
    1.2407
   ],
   "I2": 33.4458,
   "tau2": 0.0072,
   "Q": 7.5127,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "EPIC (Norat 2005)"
   ]
  },
  "proximal_colon: + UK Biobank (Bradbury) + EPIC (Norat)": {
   "k": 7,
   "re": [
    1.0538,
    0.947,
    1.1727
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   "fe": [
    1.0689,
    0.9923,
    1.1514
   ],
   "reml": [
    1.0493,
    0.9315,
    1.1821
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   "hksj": [
    1.0538,
    0.9208,
    1.2061
   ],
   "I2": 20.209,
   "tau2": 0.0041,
   "Q": 7.5196,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)",
    "EPIC (Norat 2005)"
   ]
  },
  "distal_colon: + EPIC (Norat 2005 left side, GL)": {
   "k": 6,
   "re": [
    1.1646,
    0.9238,
    1.4682
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   "fe": [
    1.1182,
    1.0232,
    1.2221
   ],
   "reml": [
    1.1884,
    0.8977,
    1.5732
   ],
   "hksj": [
    1.1646,
    0.8148,
    1.6645
   ],
   "I2": 75.7126,
   "tau2": 0.0495,
   "Q": 20.5868,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "EPIC (Norat 2005)"
   ]
  },
  "distal_colon: + UK Biobank (Bradbury) + EPIC (Norat)": {
   "k": 7,
   "re": [
    1.2474,
    0.9836,
    1.5819
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   "fe": [
    1.1341,
    1.0385,
    1.2383
   ],
   "reml": [
    1.2966,
    0.9546,
    1.761
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   "hksj": [
    1.2474,
    0.8704,
    1.7877
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   "I2": 76.5608,
   "tau2": 0.0598,
   "Q": 25.5981,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)",
    "EPIC (Norat 2005)"
   ]
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  "colon: calibrated EPIC (Norat) only": {
   "k": 11,
   "re": [
    1.1091,
    0.9947,
    1.2366
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   "fe": [
    1.0992,
    1.0396,
    1.1622
   ],
   "reml": [
    1.1145,
    0.9896,
    1.2552
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   "hksj": [
    1.1091,
    0.9655,
    1.2741
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   "I2": 45.6428,
   "tau2": 0.0109,
   "Q": 18.3968,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
   ]
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  "colon: calibrated EPIC (Norat) + regression-dilution-corrected UK Biobank (Knuppel)": {
   "k": 11,
   "re": [
    1.1102,
    0.9954,
    1.2382
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   "fe": [
    1.0997,
    1.04,
    1.1627
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   "reml": [
    1.1167,
    0.9891,
    1.2608
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   "hksj": [
    1.1102,
    0.9661,
    1.2758
   ],
   "I2": 46.0828,
   "tau2": 0.0111,
   "Q": 18.547,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
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    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
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  "rectum: calibrated EPIC (Norat) only": {
   "k": 11,
   "re": [
    1.1415,
    1.0383,
    1.2549
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   "fe": [
    1.1415,
    1.0383,
    1.2549
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   "reml": [
    1.1415,
    1.0383,
    1.255
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   "hksj": [
    1.1415,
    1.0324,
    1.2621
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   "I2": 0.0,
   "tau2": 0.0,
   "Q": 8.7036,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
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    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
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  "rectum: calibrated EPIC (Norat) + regression-dilution-corrected UK Biobank (Knuppel)": {
   "k": 11,
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    1.1418,
    1.0386,
    1.2552
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   "fe": [
    1.1418,
    1.0386,
    1.2552
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   "reml": [
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    1.0386,
    1.2553
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   "hksj": [
    1.1418,
    1.0329,
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   "I2": 0.0,
   "tau2": 0.0,
   "Q": 8.6591,
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    "MCCS (English 2004)",
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    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
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    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
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  },
  "proximal_colon: + UK Biobank (Bradbury 2020, regression-dilution corrected per 50 g -> ^2)": {
   "k": 6,
   "re": [
    1.0357,
    0.9189,
    1.1673
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   "fe": [
    1.0628,
    0.9855,
    1.1461
   ],
   "reml": [
    1.0265,
    0.8936,
    1.1792
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   "hksj": [
    1.0357,
    0.8838,
    1.2137
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   "I2": 28.4518,
   "tau2": 0.0059,
   "Q": 6.9883,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)"
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  },
  "distal_colon: + UK Biobank (Bradbury 2020, regression-dilution corrected per 50 g -> ^2)": {
   "k": 6,
   "re": [
    1.2752,
    0.9684,
    1.679
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   "fe": [
    1.1311,
    1.0334,
    1.238
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   "reml": [
    1.3506,
    0.9167,
    1.9899
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   "hksj": [
    1.2752,
    0.8027,
    2.0258
   ],
   "I2": 80.7474,
   "tau2": 0.0713,
   "Q": 25.9705,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)",
    "UK Biobank (Bradbury 2020)"
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  "colon: textbook GL covariance for the GL rows (UK Biobank (Knuppel 2020), SMC (Larsson 2005), BWHS (Yiannakou 2022))": {
   "k": 11,
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    1.0058,
    1.2259
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   "fe": [
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    1.0448,
    1.1644
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   "reml": [
    1.1088,
    1.0081,
    1.2194
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   "hksj": [
    1.1104,
    0.9791,
    1.2595
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   "I2": 44.5053,
   "tau2": 0.0093,
   "Q": 18.0197,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
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    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
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  "rectum: textbook GL covariance for the GL rows (UK Biobank (Knuppel 2020), SMC (Larsson 2005), BWHS (Yiannakou 2022))": {
   "k": 11,
   "re": [
    1.1393,
    1.041,
    1.247
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   "fe": [
    1.1393,
    1.041,
    1.247
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   "reml": [
    1.1393,
    1.0409,
    1.2471
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   "hksj": [
    1.1393,
    1.0358,
    1.2533
   ],
   "I2": 0.0,
   "tau2": 0.0,
   "Q": 8.6189,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
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  },
  "proximal_colon: textbook GL covariance for the GL rows (SMC (Larsson 2005), BWHS (Yiannakou 2022))": {
   "k": 5,
   "re": [
    1.0253,
    0.8939,
    1.1761
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   "fe": [
    1.0622,
    0.9844,
    1.1462
   ],
   "reml": [
    1.0177,
    0.8721,
    1.1875
   ],
   "hksj": [
    1.0253,
    0.8362,
    1.2573
   ],
   "I2": 41.8585,
   "tau2": 0.009,
   "Q": 6.8798,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "distal_colon: textbook GL covariance for the GL rows (SMC (Larsson 2005), BWHS (Yiannakou 2022))": {
   "k": 5,
   "re": [
    1.1593,
    0.8921,
    1.5066
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   "fe": [
    1.1142,
    1.0172,
    1.2204
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   "reml": [
    1.1926,
    0.8457,
    1.6818
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   "hksj": [
    1.1593,
    0.7411,
    1.8135
   ],
   "I2": 79.7009,
   "tau2": 0.0554,
   "Q": 19.7053,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "colon: BWHS with the cohort's printed person-years instead of pseudo person-years": {
   "k": 11,
   "re": [
    1.1125,
    1.0057,
    1.2306
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   "fe": [
    1.1034,
    1.0452,
    1.1649
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   "reml": [
    1.1119,
    1.0065,
    1.2283
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   "hksj": [
    1.1125,
    0.9772,
    1.2665
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   "I2": 46.1331,
   "tau2": 0.0099,
   "Q": 18.5643,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "rectum: BWHS with the cohort's printed person-years instead of pseudo person-years": {
   "k": 11,
   "re": [
    1.1407,
    1.0422,
    1.2487
   ],
   "fe": [
    1.1407,
    1.0422,
    1.2487
   ],
   "reml": [
    1.1407,
    1.0421,
    1.2487
   ],
   "hksj": [
    1.1407,
    1.0465,
    1.2435
   ],
   "I2": 0.0,
   "tau2": 0.0,
   "Q": 7.0506,
   "studies": [
    "MCCS (English 2004)",
    "EPIC (Norat 2005)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "SWHS (Lee 2009)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "proximal_colon: BWHS with the cohort's printed person-years instead of pseudo person-years": {
   "k": 5,
   "re": [
    1.0272,
    0.8938,
    1.1806
   ],
   "fe": [
    1.0632,
    0.9852,
    1.1473
   ],
   "reml": [
    1.0207,
    0.8741,
    1.1918
   ],
   "hksj": [
    1.0272,
    0.8337,
    1.2657
   ],
   "I2": 42.8008,
   "tau2": 0.0094,
   "Q": 6.9931,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "distal_colon: BWHS with the cohort's printed person-years instead of pseudo person-years": {
   "k": 5,
   "re": [
    1.1654,
    0.8901,
    1.5257
   ],
   "fe": [
    1.1135,
    1.0164,
    1.2199
   ],
   "reml": [
    1.2101,
    0.8346,
    1.7545
   ],
   "hksj": [
    1.1654,
    0.7214,
    1.8826
   ],
   "I2": 80.4149,
   "tau2": 0.0584,
   "Q": 20.4237,
   "studies": [
    "SMC (Larsson 2005)",
    "JPHC + Takayama (Islam 2019)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "BWHS (Yiannakou 2022)"
   ]
  }
 },
 "reporting_bias": {
  "table": [
   {
    "cohort": "Netherlands MP (Tiemersma 2002)",
    "crc_cases": 102,
    "crc_weight_re": 0.3738,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "site analysis for fish only"
   },
   {
    "cohort": "MCCS (English 2004)",
    "crc_cases": 451,
    "crc_weight_re": 2.8511,
    "site_source": "MCCS (English 2004)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 283,
     "rectum": 169,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   },
   {
    "cohort": "EPIC (Papadimitriou 2022)",
    "crc_cases": 5069,
    "crc_weight_re": 16.2796,
    "site_source": "EPIC (Norat 2005)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 855,
     "rectum": 474,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   },
   {
    "cohort": "SMC (Larsson 2005)",
    "crc_cases": 733,
    "crc_weight_re": 2.3967,
    "site_source": "SMC (Larsson 2005)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": true,
     "distal_colon": true
    },
    "colon_mode": "constructed (R8.3)",
    "cases": {
     "colon": 389,
     "rectum": 230,
     "proximal_colon": 234,
     "distal_colon": 155
    },
    "why_not": null
   },
   {
    "cohort": "MEC (Ollberding 2012)",
    "crc_cases": 3404,
    "crc_weight_re": 8.3458,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "colon/rectum analysed, 'data not shown'"
   },
   {
    "cohort": "NLCS (Gilsing 2015)",
    "crc_cases": 437,
    "crc_weight_re": 4.9217,
    "site_source": "NLCS (Gilsing 2015)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 307,
     "rectum": 92,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   },
   {
    "cohort": "JPHC + Takayama (Islam 2019)",
    "crc_cases": 3550,
    "crc_weight_re": 6.2443,
    "site_source": "JPHC + Takayama (Islam 2019)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": true,
     "distal_colon": true
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 2552,
     "rectum": 1127,
     "proximal_colon": 1200,
     "distal_colon": 1150
    },
    "why_not": null
   },
   {
    "cohort": "UK Biobank (Knuppel 2020)",
    "crc_cases": 3201,
    "crc_weight_re": 2.403,
    "site_source": "UK Biobank (Knuppel 2020)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 2114,
     "rectum": 1109,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   },
   {
    "cohort": "DANSDA (Mejborn 2021)",
    "crc_cases": 127,
    "crc_weight_re": 1.2422,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "colorectal only"
   },
   {
    "cohort": "Israel pooled (Dankner 2024)",
    "crc_cases": 813,
    "crc_weight_re": 2.9354,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "colorectal and GI only (suppl. S1-S6 checked)"
   },
   {
    "cohort": "Sister Study (Mehta 2020)",
    "crc_cases": 210,
    "crc_weight_re": 0.8911,
    "site_source": "Sister Study (Mehta 2020)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 116,
     "rectum": 30,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   },
   {
    "cohort": "NIH-AARP (Zouiouich 2025)",
    "crc_cases": 9461,
    "crc_weight_re": 24.8945,
    "site_source": "NIH-AARP (Zouiouich 2025)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": true,
     "distal_colon": true
    },
    "colon_mode": "constructed (R8.3)",
    "cases": {
     "colon": 7002,
     "rectum": 2208,
     "proximal_colon": 4565,
     "distal_colon": 2437
    },
    "why_not": null
   },
   {
    "cohort": "NHS + HPFS (Bernstein 2015)",
    "crc_cases": 2731,
    "crc_weight_re": 13.4973,
    "site_source": "NHS + HPFS (Bernstein 2015)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": true,
     "distal_colon": true
    },
    "colon_mode": "direct",
    "cases": {
     "colon": null,
     "rectum": 589,
     "proximal_colon": 1151,
     "distal_colon": 817
    },
    "why_not": null
   },
   {
    "cohort": "Million Women (Papier 2025)",
    "crc_cases": 12251,
    "crc_weight_re": 4.6937,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "sites only for red + processed meat (excl. R8.1)"
   },
   {
    "cohort": "Alberta's Tomorrow (Al Rajabi 2021)",
    "crc_cases": 257,
    "crc_weight_re": 0.6668,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "no site breakdown in main text (Suppl. A-C not on disk)"
   },
   {
    "cohort": "BWHS (Yiannakou 2022)",
    "crc_cases": 564,
    "crc_weight_re": 0.5589,
    "site_source": "BWHS (Yiannakou 2022)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": true,
     "distal_colon": true
    },
    "colon_mode": "constructed (R8.3)",
    "cases": {
     "colon": 314,
     "rectum": 104,
     "proximal_colon": 222,
     "distal_colon": 92
    },
    "why_not": null
   },
   {
    "cohort": "Finnish cohorts (Tammi 2024)",
    "crc_cases": 1124,
    "crc_weight_re": 5.1691,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "colorectal only (Online Resources 1-5 checked)"
   },
   {
    "cohort": "Korea (Wie 2014)",
    "crc_cases": 53,
    "crc_weight_re": 0.5673,
    "site_source": null,
    "reports": {
     "colon": false,
     "rectum": false,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": null,
    "cases": {
     "colon": null,
     "rectum": null,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": "colorectal only"
   },
   {
    "cohort": "SWHS (Lee 2009)",
    "crc_cases": 394,
    "crc_weight_re": 1.0676,
    "site_source": "SWHS (Lee 2009)",
    "reports": {
     "colon": true,
     "rectum": true,
     "proximal_colon": false,
     "distal_colon": false
    },
    "colon_mode": "direct",
    "cases": {
     "colon": 236,
     "rectum": 158,
     "proximal_colon": null,
     "distal_colon": null
    },
    "why_not": null
   }
  ],
  "n_cohorts": 19,
  "n_reporting_colon": 11,
  "n_reporting_subsites": 5,
  "nonreporting": [
   "Netherlands MP (Tiemersma 2002)",
   "MEC (Ollberding 2012)",
   "DANSDA (Mejborn 2021)",
   "Israel pooled (Dankner 2024)",
   "Million Women (Papier 2025)",
   "Alberta's Tomorrow (Al Rajabi 2021)",
   "Finnish cohorts (Tammi 2024)",
   "Korea (Wie 2014)"
  ],
  "nonreporting_crc_cases": 18131,
  "total_crc_cases": 44932,
  "nonreporting_case_share": 0.4035,
  "nonreporting_crc_weight_pct": 23.9942,
  "total_weight_check": 100.0,
  "subsite_nonreporting_crc_weight_pct": 52.4083,
  "subsite_nonreporting_crc_cases": 27893,
  "inventory_claim": {
   "weight_pct": 23.9,
   "cases": 18316,
   "case_share_pct": 41,
   "set": "20 cohorts incl. ATBC (Pietinen 1999, 185 cases, colorectal only), before R100"
  },
  "inventory_claim_verified": true,
  "site_cases_in_pools": {
   "colon": 14168,
   "rectum": 6290,
   "proximal_colon": 7372,
   "distal_colon": 4651
  }
 },
 "comparison": {
  "CUP 2016 colon (published 1.22 (1.06-1.39); reproduced)": {
   "k": 11,
   "re": [
    1.2159,
    1.0631,
    1.3908
   ],
   "I2": 11.8908,
   "source": "all.json cup2016 run 'Colon – published per-study values (SLR 2016 Fig. 132, p363)'"
  },
  "CUP 2016 colon set, corrected + later follow-ups (Islam 2019, Bernstein 2015)": {
   "k": 8,
   "re": [
    1.0656,
    0.9432,
    1.2039
   ],
   "I2": 16.0745,
   "source": "all.json cup2016 run 'Colon – corrected + follow-ups'"
  },
  "2026 colorectal pool (update2026.json)": {
   "k": 19,
   "re": [
    1.0987,
    1.0455,
    1.1546
   ],
   "I2": 14.9393
  }
 },
 "checks": {
  "gl_recomputation": {
   "UK Biobank (Knuppel 2020) colon": {
    "pipeline_recomputed": [
     1.8649,
     1.2725,
     2.7331
    ],
    "textbook": [
     1.9019,
     1.2855,
     2.8138
    ],
    "used": [
     1.8649,
     1.2725,
     2.7331
    ]
   },
   "UK Biobank (Knuppel 2020) rectum": {
    "pipeline_recomputed": [
     0.9697,
     0.5853,
     1.6066
    ],
    "textbook": [
     0.9465,
     0.5717,
     1.567
    ],
    "used": [
     0.9697,
     0.5853,
     1.6066
    ]
   },
   "SMC (Larsson 2005) proximal_colon": {
    "pipeline_recomputed": [
     1.1676,
     0.6648,
     2.0507
    ],
    "textbook": [
     1.1096,
     0.6408,
     1.9216
    ],
    "used": [
     1.1676,
     0.6648,
     2.0507
    ]
   },
   "SMC (Larsson 2005) distal_colon": {
    "pipeline_recomputed": [
     2.5912,
     1.4012,
     4.7916
    ],
    "textbook": [
     2.3294,
     1.3211,
     4.1073
    ],
    "used": [
     2.5912,
     1.4012,
     4.7916
    ]
   },
   "SMC (Larsson 2005) rectum": {
    "pipeline_recomputed": [
     0.9782,
     0.555,
     1.7244
    ],
    "textbook": [
     0.9359,
     0.5407,
     1.6201
    ],
    "used": [
     0.9782,
     0.555,
     1.7244
    ]
   },
   "BWHS (Yiannakou 2022) proximal_colon": {
    "pipeline_recomputed": [
     0.5813,
     0.2023,
     1.6702
    ],
    "textbook": [
     0.5905,
     0.2095,
     1.6642
    ],
    "used": [
     0.5813,
     0.2023,
     1.6702
    ]
   },
   "BWHS (Yiannakou 2022) distal_colon": {
    "pipeline_recomputed": [
     1.345,
     0.2582,
     7.0074
    ],
    "textbook": [
     1.3824,
     0.2716,
     7.0357
    ],
    "used": [
     1.345,
     0.2582,
     7.0074
    ]
   },
   "BWHS (Yiannakou 2022) rectum": {
    "pipeline_recomputed": [
     3.1225,
     0.6166,
     15.8137
    ],
    "textbook": [
     4.3839,
     0.8289,
     23.1851
    ],
    "used": [
     3.1225,
     0.6166,
     15.8137
    ]
   }
  },
  "larsson_vs_cup2016": {
   "proximal": {
    "own": [
     1.1676,
     0.6648,
     2.0507
    ],
    "cup": [
     1.17,
     0.66,
     2.05
    ]
   },
   "distal": {
    "own": [
     2.5912,
     1.4012,
     4.7916
    ],
    "cup": [
     2.59,
     1.4,
     4.79
    ]
   },
   "rectum": {
    "own": [
     0.9782,
     0.555,
     1.7244
    ],
    "cup": [
     0.98,
     0.55,
     1.72
    ]
   }
  }
 },
 "sensitivity_rows": {
  "bradbury_gl": {
   "proximal_colon": {
    "rr": 1.0961,
    "lo": 0.6051,
    "hi": 1.9856,
    "prov": "bradbury2020_209;bradbury2020_210;bradbury2020_211;bradbury2020_212 [GL_categories; paper_dose_point]",
    "where": "Suppl Table S9, suppl"
   },
   "distal_colon": {
    "rr": 2.324,
    "lo": 1.2324,
    "hi": 4.3824,
    "prov": "bradbury2020_214;bradbury2020_215;bradbury2020_216;bradbury2020_217 [GL_categories; paper_dose_point]",
    "where": "Suppl Table S9, suppl"
   }
  },
  "bradbury_calibrated": {
   "proximal_colon": {
    "rr": 1.0404,
    "lo": 0.5929,
    "hi": 1.8496,
    "prov": "bradbury2020_213 [continuous_scaled; per_50g]",
    "where": "Suppl Table S9, suppl"
   },
   "distal_colon": {
    "rr": 2.4025,
    "lo": 1.2769,
    "hi": 4.5369,
    "prov": "bradbury2020_218 [continuous_scaled; per_50g]",
    "where": "Suppl Table S9, suppl"
   }
  },
  "norat_right_left_gl": {
   "proximal_colon": {
    "rr": 1.2483,
    "lo": 0.8158,
    "hi": 1.9099,
    "prov": "norat2005_016;norat2005_017;norat2005_018;norat2005_019;norat2005_020 [GL_categories (pipeline K19 covariance); conversion::cup_rule; cases ASSUMED: site total 351 (Table 3) split proportional to RR]",
    "where": "Table 3, 911"
   },
   "distal_colon": {
    "rr": 1.2063,
    "lo": 0.8178,
    "hi": 1.7794,
    "prov": "norat2005_021;norat2005_022;norat2005_023;norat2005_024;norat2005_025 [GL_categories (pipeline K19 covariance); conversion::cup_rule; cases ASSUMED: site total 391 (Table 3) split proportional to RR]",
    "where": "Table 3, 911"
   }
  },
  "calibrated": {
   "colon": {
    "EPIC (Norat 2005)": {
     "rr": 1.36,
     "lo": 0.74,
     "hi": 2.5,
     "prov": "norat2005_034 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    },
    "UK Biobank (Knuppel 2020)": {
     "rr": 1.8496,
     "lo": 1.2769,
     "hi": 2.6896,
     "prov": "knuppel2020_120 [continuous_scaled; per_50g]",
     "where": "Suppl Table S5, suppl p. 19"
    }
   },
   "rectum": {
    "EPIC (Norat 2005)": {
     "rr": 1.75,
     "lo": 0.93,
     "hi": 3.3,
     "prov": "norat2005_036 [continuous_scaled; per_100g]",
     "where": "Table 4, 912"
    },
    "UK Biobank (Knuppel 2020)": {
     "rr": 0.9801,
     "lo": 0.5929,
     "hi": 1.6129,
     "prov": "knuppel2020_135 [continuous_scaled; per_50g]",
     "where": "Suppl Table S5, suppl p. 19"
    }
   }
  },
  "textbook_gl": {
   "UK Biobank (Knuppel 2020)": {
    "colon": {
     "rr": 1.9019,
     "lo": 1.2855,
     "hi": 2.8138
    },
    "rectum": {
     "rr": 0.9465,
     "lo": 0.5717,
     "hi": 1.567
    }
   },
   "SMC (Larsson 2005)": {
    "proximal_colon": {
     "rr": 1.1096,
     "lo": 0.6408,
     "hi": 1.9216
    },
    "distal_colon": {
     "rr": 2.3294,
     "lo": 1.3211,
     "hi": 4.1073
    },
    "rectum": {
     "rr": 0.9359,
     "lo": 0.5407,
     "hi": 1.6201
    },
    "colon": {
     "rr": 1.5886,
     "lo": 1.0707,
     "hi": 2.3569
    }
   },
   "BWHS (Yiannakou 2022)": {
    "proximal_colon": {
     "rr": 0.5905,
     "lo": 0.2095,
     "hi": 1.6642
    },
    "distal_colon": {
     "rr": 1.3824,
     "lo": 0.2716,
     "hi": 7.0357
    },
    "rectum": {
     "rr": 4.3839,
     "lo": 0.8289,
     "hi": 23.1851
    },
    "colon": {
     "rr": 0.7547,
     "lo": 0.3149,
     "hi": 1.8087
    }
   }
  },
  "bwhs_printed_py": {
   "proximal_colon": {
    "rr": 0.5793,
    "lo": 0.2012,
    "hi": 1.6674
   },
   "distal_colon": {
    "rr": 1.322,
    "lo": 0.2537,
    "hi": 6.8889
   },
   "rectum": {
    "rr": 2.8839,
    "lo": 0.5809,
    "hi": 14.3181
   },
   "colon": {
    "rr": 0.7364,
    "lo": 0.3023,
    "hi": 1.7938
   }
  }
 },
 "cup2016_five_common": {
  "cohorts": [
   "lee2009",
   "larsson2005",
   "norat2005",
   "english2004",
   "jarvinen2001"
  ],
  "note": "CUP 2016 per-study values for the 5 cohorts in all three CUP pools; SMC proximal+distal combined (fixed) for colon",
  "colorectal": {
   "k": 5,
   "re": [
    1.1915,
    1.0556,
    1.3448
   ],
   "I2": 0.0,
   "rows": [
    {
     "study": "lee2009",
     "rr": 0.81,
     "lo": 0.5,
     "hi": 1.29
    },
    {
     "study": "larsson2005",
     "rr": 1.23,
     "lo": 0.9,
     "hi": 1.67
    },
    {
     "study": "norat2005",
     "rr": 1.21,
     "lo": 1.02,
     "hi": 1.43
    },
    {
     "study": "english2004",
     "rr": 1.19,
     "lo": 0.89,
     "hi": 1.58
    },
    {
     "study": "jarvinen2001",
     "rr": 1.37,
     "lo": 0.92,
     "hi": 2.06
    }
   ]
  },
  "colon": {
   "k": 5,
   "re": [
    1.209,
    1.016,
    1.4385
   ],
   "I2": 9.4336,
   "rows": [
    {
     "study": "lee2009",
     "rr": 0.86,
     "lo": 0.43,
     "hi": 1.74
    },
    {
     "study": "larsson2005_proximal",
     "rr": 1.6852,
     "lo": 1.1108,
     "hi": 2.5564
    },
    {
     "study": "norat2005",
     "rr": 1.2,
     "lo": 0.96,
     "hi": 1.48
    },
    {
     "study": "english2004",
     "rr": 1.0,
     "lo": 0.69,
     "hi": 1.46
    },
    {
     "study": "jarvinen2001",
     "rr": 1.3,
     "lo": 0.77,
     "hi": 2.17
    }
   ]
  },
  "rectum": {
   "k": 5,
   "re": [
    1.2221,
    1.0013,
    1.4915
   ],
   "I2": 0.0,
   "rows": [
    {
     "study": "lee2009",
     "rr": 0.74,
     "lo": 0.33,
     "hi": 1.66
    },
    {
     "study": "larsson2005",
     "rr": 0.98,
     "lo": 0.55,
     "hi": 1.72
    },
    {
     "study": "norat2005",
     "rr": 1.23,
     "lo": 0.94,
     "hi": 1.62
    },
    {
     "study": "english2004",
     "rr": 1.57,
     "lo": 0.99,
     "hi": 2.49
    },
    {
     "study": "jarvinen2001",
     "rr": 1.32,
     "lo": 0.69,
     "hi": 2.53
    }
   ]
  }
 },
 "r87": {
  "colon_significantly_above_1": true,
  "colon_hksj_above_1": false,
  "colon_reml_above_1": true,
  "distal_point_gt_proximal": true,
  "rectum_point_gt_proximal": true,
  "proximal_vs_distal_ratio_significant": false,
  "rectum_vs_proximal_ratio_significant": false
 }
}