{
 "set": [
  {
   "key": "Netherlands MP (Tiemersma 2002)",
   "rr": 1.9191,
   "lo": 0.8556,
   "hi": 4.3047,
   "w": 0.3738205622793005,
   "region": "Europe",
   "sex": "both",
   "expo": "fresh red meat",
   "cases": 102,
   "prov": "tiemersma2002_010;tiemersma2002_011;tiemersma2002_012 [GL_categories; conversion:cup:cup_rule]",
   "note": "nested case-control; GL with CUP dose rule (CUP's own 1.69 used 'as-used' doses not printed)"
  },
  {
   "key": "MCCS (English 2004)",
   "rr": 1.1882,
   "lo": 0.8888,
   "hi": 1.5666,
   "w": 2.8511127551730686,
   "region": "Australia",
   "sex": "both",
   "expo": "fresh red meat",
   "cases": 451,
   "prov": "english2004_005 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]",
   "note": "per serving/week × 5.83 (120 g/serving); main model not adjusted for processed meat"
  },
  {
   "key": "EPIC (Papadimitriou 2022)",
   "rr": 1.0562272809740614,
   "lo": 0.9457201447694336,
   "hi": 1.144284394932628,
   "w": 16.27960113134325,
   "region": "Europe",
   "sex": "both",
   "expo": "red meat (EPIC definition, fresh)",
   "cases": 5069,
   "prov": "papadimitriou2022_001 [^2.762]",
   "note": "per SD (36.2 g) → per 100 g; latest EPIC follow-up"
  },
  {
   "key": "SMC (Larsson 2005)",
   "rr": 1.2252,
   "lo": 0.8978,
   "hi": 1.6721,
   "w": 2.396692473379757,
   "region": "Europe",
   "sex": "women",
   "expo": "beef/pork main dish (unprocessed)",
   "cases": 733,
   "prov": "larsson2005_033;larsson2005_034;larsson2005_035;larsson2005_036 [GL_categories; conversion:cup:paper_median]",
   "note": "GL from paper's category medians × 120 g (CUP's construction)"
  },
  {
   "key": "MEC (Ollberding 2012)",
   "rr": 0.9665,
   "lo": 0.8292,
   "hi": 1.1264,
   "w": 8.345832425068963,
   "region": "N America",
   "sex": "both",
   "expo": "red meat excluding processed",
   "cases": 3404,
   "prov": "ollberding2012_066;ollberding2012_067;ollberding2012_068;ollberding2012_069;ollberding2012_070 [GL_categories; conversion:cup:paper_median]",
   "note": "GL with SLR energy conversion"
  },
  {
   "key": "NLCS (Gilsing 2015)",
   "rr": 1.0,
   "lo": 0.81,
   "hi": 1.2321,
   "w": 4.921684116560864,
   "region": "Europe",
   "sex": "both",
   "expo": "fresh red meat",
   "cases": 437,
   "prov": "gilsing2015_118 [continuous_scaled; per_50g]",
   "note": "per 50 g → ^2; case-cohort"
  },
  {
   "key": "JPHC + Takayama (Islam 2019)",
   "rr": 1.0879289499490137,
   "lo": 0.9062460355191965,
   "hi": 1.3060353962917748,
   "w": 6.244298288229828,
   "region": "Asia",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 3550,
   "prov": "islam2019_149 [continuous_scaled; per_100g]; islam2019_274 [continuous_scaled; per_100g] [strata combined, fixed]",
   "note": "pooled JPHC 5-y + Takayama; sex strata combined (fixed); replaces Takachi 2011 and Oba/Wada"
  },
  {
   "key": "UK Biobank (Knuppel 2020)",
   "rr": 1.4956,
   "lo": 1.0964,
   "hi": 2.0402,
   "w": 2.4030343520301347,
   "region": "Europe",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 3201,
   "prov": "knuppel2020_101;knuppel2020_102;knuppel2020_103;knuppel2020_104 [GL_categories; paper_dose_point]",
   "note": "GL from category means, model 2"
  },
  {
   "key": "DANSDA (Mejborn 2021)",
   "rr": 1.04,
   "lo": 0.67,
   "hi": 1.61,
   "w": 1.2422387360797047,
   "region": "Europe",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 127,
   "prov": "mejborn2021_006 [continuous_scaled; per_100g]",
   "note": "per 100 g"
  },
  {
   "key": "Israel pooled (Dankner 2024)",
   "rr": 1.15,
   "lo": 0.87,
   "hi": 1.52,
   "w": 2.935399993640986,
   "region": "Other",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 813,
   "prov": "dankner2024_016 [continuous_scaled; per_100g]",
   "note": "three Israeli cohorts, authors' meta-analysis"
  },
  {
   "key": "Sister Study (Mehta 2020)",
   "rr": 1.2996,
   "lo": 0.7744,
   "hi": 2.1904,
   "w": 0.8910541279097189,
   "region": "N America",
   "sex": "women",
   "expo": "unprocessed red meat",
   "cases": 210,
   "prov": "mehta2020_016 [continuous_scaled; per_50g]",
   "note": "per 50 g → ^2"
  },
  {
   "key": "NIH-AARP (Zouiouich 2025)",
   "rr": 1.13,
   "lo": 1.06,
   "hi": 1.2,
   "w": 24.89445749043384,
   "region": "N America",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 9461,
   "prov": "zouiouich2025_134",
   "note": "addition model, per 50 g/1000 kcal ≈ per 100 g/day at 2000 kcal/day (assumption)"
  },
  {
   "key": "NHS + HPFS (Bernstein 2015)",
   "rr": 1.0,
   "lo": 0.89,
   "hi": 1.11,
   "w": 13.497316874866746,
   "region": "N America",
   "sex": "both",
   "expo": "unprocessed red meat (incl. hamburger)",
   "cases": 2731,
   "prov": "bernstein2015_488 [continuous_scaled; per_100g]",
   "note": "Suppl. S5, per 100 g"
  },
  {
   "key": "Million Women (Papier 2025)",
   "rr": 1.2763,
   "lo": 1.0,
   "hi": 1.5386,
   "w": 4.693672812654419,
   "region": "Europe",
   "sex": "women",
   "expo": "red meat (unprocessed, partial)",
   "cases": 12251,
   "prov": "papier2025_007 [continuous_scaled; per_20g]",
   "note": "Suppl. Data 1, per 20 g → ^5, measurement-error corrected"
  },
  {
   "key": "Alberta's Tomorrow (Al Rajabi 2021)",
   "rr": 1.2505779192602378,
   "lo": 0.6845069206009398,
   "hi": 2.2847762163869034,
   "w": 0.6667940087920138,
   "region": "N America",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 257,
   "prov": "alrajabi2021_057;alrajabi2021_059;alrajabi2021_061;alrajabi2021_063 [GL_categories; conversion::cup_rule]; alrajabi2021_058;alrajabi2021_060;alrajabi2021_062;alrajabi2021_064 [GL_categories; conversion::cup_rule] [strata combined, fixed]",
   "note": "GL, sex strata combined"
  },
  {
   "key": "BWHS (Yiannakou 2022)",
   "rr": 1.6262,
   "lo": 0.8412,
   "hi": 3.1436,
   "w": 0.5589106436393668,
   "region": "N America",
   "sex": "women",
   "expo": "unprocessed red meat (partial)",
   "cases": 564,
   "prov": "yiannakou2022_025;yiannakou2022_026;yiannakou2022_027 [GL_categories; conversion:paper:cup_rule]",
   "note": "GL from tertiles"
  },
  {
   "key": "Finnish cohorts (Tammi 2024)",
   "rr": 1.2299,
   "lo": 1.0,
   "hi": 1.5036,
   "w": 5.169138589780218,
   "region": "Europe",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 1124,
   "prov": "tammi2024_003 [continuous_scaled; per_100g_week]",
   "note": "per 100 g/week → ^7"
  },
  {
   "key": "Korea (Wie 2014)",
   "rr": 0.9044,
   "lo": 0.484,
   "hi": 1.7908,
   "w": 0.5673351809973209,
   "region": "Asia",
   "sex": "both",
   "expo": "unprocessed red meat",
   "cases": 53,
   "prov": "wie2014_007 [continuous_scaled; per_10g]",
   "note": "per 10 g → ^10"
  },
  {
   "key": "SWHS (Lee 2009)",
   "rr": 0.81,
   "lo": 0.5,
   "hi": 1.29,
   "w": 1.0676054371405077,
   "region": "Asia",
   "sex": "women",
   "expo": "red meat (undefined; mainly pork)",
   "cases": 394,
   "prov": "CUP 2016 cup2016_lee2009_colorectal",
   "note": "CUP 2016's extraction (GL); exposure definition not separable"
  }
 ],
 "main": {
  "k": 19,
  "re": [
   1.0986748969311173,
   1.045489548479073,
   1.1545658499433225
  ],
  "fe": [
   1.0983813945245888,
   1.0564865199851505,
   1.1419376064114264
  ],
  "I2": 14.939308786246572,
  "tau2": 0.0015730731489492682,
  "Q": 21.161361074255634,
  "reml": [
   1.098824163571634,
   1.0452655597118208,
   1.1551270691266102,
   0.001644141239484401
  ],
  "hksj": [
   1.0986748969311173,
   1.0415978375108212,
   1.1588796420999297
  ],
  "egger": [
   0.44357920532110645,
   0.2798788770965617
  ],
  "loo": {
   "tiemersma2002": [
    1.0957956079393696,
    1.0449339870258023,
    1.1491328919226382
   ],
   "english2004": [
    1.096909681808976,
    1.0409958093335787,
    1.1558267951304597
   ],
   "papadimitriou2022": [
    1.1083716247527857,
    1.0469395053472175,
    1.1734084465078065
   ],
   "larsson2005": [
    1.0962668919941991,
    1.0410152682547122,
    1.1544509817780773
   ],
   "ollberding2012": [
    1.1089527151854977,
    1.0585457175703832,
    1.1617600488148205
   ],
   "gilsing2015": [
    1.1046026204957577,
    1.0487677125550507,
    1.1634100998718995
   ],
   "islam2019": [
    1.1009746436105448,
    1.042701140662981,
    1.1625048814108399
   ],
   "knuppel2020": [
    1.092028459526129,
    1.048437144362724,
    1.1374321892609673
   ],
   "mejborn2021": [
    1.1006037790559002,
    1.0445534217604835,
    1.1596617781698166
   ],
   "dankner2024": [
    1.0982007759958852,
    1.0417070061060623,
    1.1577583114336563
   ],
   "mehta2020": [
    1.0976068143945212,
    1.0426669349013913,
    1.1554415688066542
   ],
   "zouiouich2025": [
    1.091387613557601,
    1.028394961031999,
    1.158238778058242
   ],
   "bernstein2015": [
    1.11309766791086,
    1.0618020686919567,
    1.1668713546912877
   ],
   "papier2025": [
    1.0902775884910212,
    1.0385824405562298,
    1.1445458478280897
   ],
   "alrajabi2021": [
    1.0985780736553887,
    1.0431339962025032,
    1.1569690838473015
   ],
   "yiannakou2022": [
    1.0959875481730108,
    1.0437216818832398,
    1.1508707029856104
   ],
   "tammi2024": [
    1.0919008219625246,
    1.0378155967433307,
    1.1488046708333481
   ],
   "wie2014": [
    1.1007154371446695,
    1.0455857128765846,
    1.1587519403218822
   ],
   "lee2009": [
    1.1015370308425039,
    1.049495344832791,
    1.156159325804956
   ]
  }
 },
 "excluded": [
  [
   "Wang 2020 (NHS + NHSII + HPFS)",
   "new in the 2026 search (fetched by the author); overlaps NHS/HPFS; no whole-population all-CRC estimate for unprocessed red meat (only by age at onset) and no serving size defined — shown as sensitivity replacing Bernstein 2015"
  ],
  [
   "Nguyen 2020 (Shanghai Women's Health Study)",
   "fetched; red and processed meat only as a diet-score component"
  ],
  [
   "Vulcan 2017 (Malmö Diet and Cancer Study)",
   "new in the 2026 search; MDCS is the Malmö centre of EPIC, already inside Papadimitriou 2022 — overlap; shown as sensitivity"
  ],
  [
   "Andersen 2019 (Danish DCH), Beslay 2021 (NutriNet-Santé)",
   "new in the 2026 search; red and processed meat combined only (Beslay full text fetched and confirmed: HR per 50 g/day red+processed 1.42 (1.03–1.94) for CRC)"
  ],
  [
   "Pan 2023 (China Kadoorie)",
   "new in the 2026 search; early-onset CRC only, red meat frequency undefined"
  ],
  [
   "Järvinen 2001 (Finnish Mobile Clinic)",
   "exposure is total meat"
  ],
  [
   "Chao 2005 (CPS-II)",
   "red meat includes processed"
  ],
  [
   "Flood 2003 (BCDDP)",
   "red meat includes processed; superseded by nothing"
  ],
  [
   "Spencer 2010 (UK Dietary Cohort Consortium)",
   "nested case-control overlapping EPIC-Norfolk/EPIC-Oxford"
  ],
  [
   "Takachi 2011, Oba 2006, Wada 2017",
   "replaced by Islam 2019 (same cohorts)"
  ],
  [
   "Bradbury 2020",
   "UK Biobank, earlier/overlapping analysis of the cohort used through Knuppel 2020 (multiverse alternative)"
  ],
  [
   "Hoang 2023 (UK Biobank)",
   "later and larger UK Biobank analysis (4,681 cases), but only frequency categories (times/week) with no gram intake; Knuppel 2020 gives category means in grams and is kept. Hoang converted with CUP's rules (120 g/serving, midpoints) is a sensitivity analysis, not a multiverse option (R100; K26d)"
  ],
  [
   "Cross 2010",
   "NIH-AARP earlier follow-up (Zouiouich 2025 used)"
  ],
  [
   "Etemadi 2018",
   "incidence paper pooling NIH-AARP, PLCO (604 CRC cases) and the Agricultural Health Study (299); substitution-type models adjusted for total meat; cohort-specific estimates only in Suppl. Table 1, not on disk, so PLCO and AHS are not represented. NIH-AARP is covered by Zouiouich 2025. Open item: Etemadi 2018 Suppl. Table 1 not yet obtained (R102; K26d). Earlier stated reason 'NIH-AARP earlier follow-up / mortality' was wrong"
  ],
  [
   "Jin 2023",
   "per SD with no SD in grams"
  ],
  [
   "Butler 2008 (Singapore)",
   "highest vs lowest only"
  ],
  [
   "Key 2014",
   "diet-group comparison"
  ],
  [
   "Bostick 1994, Singh 1998, Sellers 1998",
   "colon only (colon pool)"
  ],
  [
   "Willett 1990, Giovannucci 1994, Wei 2004, Chan 2005",
   "NHS/HPFS earlier"
  ],
  [
   "Norat 2005",
   "EPIC earlier (multiverse)"
  ],
  [
   "Kato 1997, Chen 1998, Phillips 1975, Goldbohm 1994, Fraser 1999, Kabat 2007, Nöthlings 2009",
   "no per-gram unprocessed estimate / superseded"
  ]
 ],
 "subgroups": {
  "region: Europe": {
   "k": 8,
   "re": [
    1.1601126656115242,
    1.0485189598549458,
    1.2835832716830082
   ],
   "I2": 31.800007480985187,
   "studies": [
    "Netherlands MP (Tiemersma 2002)",
    "EPIC (Papadimitriou 2022)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "UK Biobank (Knuppel 2020)",
    "DANSDA (Mejborn 2021)",
    "Million Women (Papier 2025)",
    "Finnish cohorts (Tammi 2024)"
   ]
  },
  "region: N America": {
   "k": 6,
   "re": [
    1.06815137375227,
    0.9760107555248272,
    1.1689905575224362
   ],
   "I2": 37.89421334775937,
   "studies": [
    "MEC (Ollberding 2012)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "BWHS (Yiannakou 2022)"
   ]
  },
  "region: Asia": {
   "k": 3,
   "re": [
    1.037457924170914,
    0.8796752562351752,
    1.2235412293298331
   ],
   "I2": 0.0,
   "studies": [
    "JPHC + Takayama (Islam 2019)",
    "Korea (Wie 2014)",
    "SWHS (Lee 2009)"
   ]
  },
  "women-only cohorts": {
   "k": 5,
   "re": [
    1.2225264756810719,
    1.0483760789715022,
    1.4256057665941928
   ],
   "I2": 0.0,
   "studies": [
    "SMC (Larsson 2005)",
    "Sister Study (Mehta 2020)",
    "Million Women (Papier 2025)",
    "BWHS (Yiannakou 2022)",
    "SWHS (Lee 2009)"
   ]
  },
  "mixed/men cohorts": {
   "k": 14,
   "re": [
    1.0864528916496876,
    1.032906344246929,
    1.1427753274519374
   ],
   "I2": 15.274481046828548,
   "studies": [
    "Netherlands MP (Tiemersma 2002)",
    "MCCS (English 2004)",
    "EPIC (Papadimitriou 2022)",
    "MEC (Ollberding 2012)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "DANSDA (Mejborn 2021)",
    "Israel pooled (Dankner 2024)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "Finnish cohorts (Tammi 2024)",
    "Korea (Wie 2014)"
   ]
  },
  "explicitly unprocessed (database flag = no; excludes partial/undefined rows)": {
   "k": 13,
   "re": [
    1.1100308478046943,
    1.0301942166339415,
    1.1960545528046138
   ],
   "I2": 0.42014436200995636,
   "studies": [
    "Netherlands MP (Tiemersma 2002)",
    "MCCS (English 2004)",
    "SMC (Larsson 2005)",
    "MEC (Ollberding 2012)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "DANSDA (Mejborn 2021)",
    "Israel pooled (Dankner 2024)",
    "Sister Study (Mehta 2020)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "Finnish cohorts (Tammi 2024)",
    "Korea (Wie 2014)"
   ]
  },
  "partial / undefined exposure rows only": {
   "k": 6,
   "re": [
    1.0873998689209432,
    1.005885412439869,
    1.1755200545767628
   ],
   "I2": 44.51448436906463,
   "studies": [
    "EPIC (Papadimitriou 2022)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "Million Women (Papier 2025)",
    "BWHS (Yiannakou 2022)",
    "SWHS (Lee 2009)"
   ]
  },
  "published ≥ 2015": {
   "k": 13,
   "re": [
    1.1078391101203107,
    1.0528056208110983,
    1.1657493744824656
   ],
   "I2": 13.249440557312015,
   "studies": [
    "EPIC (Papadimitriou 2022)",
    "NLCS (Gilsing 2015)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "DANSDA (Mejborn 2021)",
    "Israel pooled (Dankner 2024)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "Million Women (Papier 2025)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "BWHS (Yiannakou 2022)",
    "Finnish cohorts (Tammi 2024)"
   ]
  },
  "published < 2015": {
   "k": 6,
   "re": [
    1.0569452362492227,
    0.9098861783189834,
    1.2277725050113752
   ],
   "I2": 19.935634051130553,
   "studies": [
    "Netherlands MP (Tiemersma 2002)",
    "MCCS (English 2004)",
    "SMC (Larsson 2005)",
    "MEC (Ollberding 2012)",
    "Korea (Wie 2014)",
    "SWHS (Lee 2009)"
   ]
  },
  "published ≤ 2015 (overview article split)": {
   "k": 8,
   "re": [
    1.0147950325199528,
    0.9416043145864068,
    1.0936748505443168
   ],
   "I2": 0.0,
   "studies": [
    "Netherlands MP (Tiemersma 2002)",
    "MCCS (English 2004)",
    "SMC (Larsson 2005)",
    "MEC (Ollberding 2012)",
    "NLCS (Gilsing 2015)",
    "NHS + HPFS (Bernstein 2015)",
    "Korea (Wie 2014)",
    "SWHS (Lee 2009)"
   ]
  },
  "published > 2015 (overview article split)": {
   "k": 11,
   "re": [
    1.1309934264035533,
    1.0806728525544613,
    1.1836571331873873
   ],
   "I2": 0.0,
   "studies": [
    "EPIC (Papadimitriou 2022)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "DANSDA (Mejborn 2021)",
    "Israel pooled (Dankner 2024)",
    "Sister Study (Mehta 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "Million Women (Papier 2025)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "BWHS (Yiannakou 2022)",
    "Finnish cohorts (Tammi 2024)"
   ]
  },
  "≥ 1000 cases": {
   "k": 8,
   "re": [
    1.0994558935782321,
    1.0268871825523342,
    1.1771529360405697
   ],
   "I2": 49.08602612499885,
   "studies": [
    "EPIC (Papadimitriou 2022)",
    "MEC (Ollberding 2012)",
    "JPHC + Takayama (Islam 2019)",
    "UK Biobank (Knuppel 2020)",
    "NIH-AARP (Zouiouich 2025)",
    "NHS + HPFS (Bernstein 2015)",
    "Million Women (Papier 2025)",
    "Finnish cohorts (Tammi 2024)"
   ]
  },
  "< 1000 cases": {
   "k": 11,
   "re": [
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    0.9974819864776068,
    1.2462885275535658
   ],
   "I2": 0.0,
   "studies": [
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    "MCCS (English 2004)",
    "SMC (Larsson 2005)",
    "NLCS (Gilsing 2015)",
    "DANSDA (Mejborn 2021)",
    "Israel pooled (Dankner 2024)",
    "Sister Study (Mehta 2020)",
    "Alberta's Tomorrow (Al Rajabi 2021)",
    "BWHS (Yiannakou 2022)",
    "Korea (Wie 2014)",
    "SWHS (Lee 2009)"
   ]
  }
 },
 "sensitivity": {
  "without Million Women (calibrated)": {
   "k": 18,
   "re": [
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    1.0385824405562298,
    1.1445458478280897
   ],
   "I2": 11.610708777030352
  },
  "without NIH-AARP (energy-density assumption)": {
   "k": 18,
   "re": [
    1.091387613557601,
    1.028394961031999,
    1.158238778058242
   ],
   "I2": 14.298370647396519
  },
  "without nested case-control (Tiemersma)": {
   "k": 18,
   "re": [
    1.0957956079393696,
    1.0449339870258023,
    1.1491328919226382
   ],
   "I2": 12.02713169643143
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  "without the two largest (MWS, NIH-AARP)": {
   "k": 17,
   "re": [
    1.0746520545132288,
    1.0150208659229085,
    1.1377864998070075
   ],
   "I2": 7.795391073188214
  },
  "UK Biobank → Hoang 2023 (frequency categories, CUP dose rules 120 g/serving)": {
   "k": 19,
   "re": [
    1.1092780735522172,
    1.052473612669398,
    1.1691484039612123
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   "I2": 23.1598513448881
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  "with Malmö DCS (Vulcan 2017) added despite EPIC overlap": {
   "k": 20,
   "re": [
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    1.0456699325635397,
    1.148668593690644
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   "I2": 11.282607635020076
  },
  "NHS/HPFS → Wang 2020 (NHS+NHSII+HPFS, per 3 servings/wk → per 100 g at 120 g/serving; age strata combined)": {
   "k": 19,
   "re": [
    1.1039449340004626,
    1.0583870106256286,
    1.1514638833151376
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   "I2": 4.814412865991372
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 },
 "multiverse": {
  "n": 1152,
  "significant": 1152,
  "median": 1.1103538907725379,
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  "max": 1.1381675369663957,
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   "EPIC (Papadimitriou 2022)": [
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    "Norat 2005 calibrated"
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   "SMC (Larsson 2005)": [
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   "MEC (Ollberding 2012)": [
    "main",
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   "JPHC + Takayama (Islam 2019)": [
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   "UK Biobank (Knuppel 2020)": [
    "main",
    "Bradbury 2020 (same cohort)"
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   "NIH-AARP (Zouiouich 2025)": [
    "main",
    "at 1800 kcal",
    "at 2200 kcal"
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     "lo": 0.8556,
     "hi": 4.3047,
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     "cohort": "monica_nl",
     "prov": "tiemersma2002_010;tiemersma2002_011;tiemersma2002_012 [GL_categories; conversion:cup:cup_rule]"
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     "rr": 1.69,
     "lo": 0.88,
     "hi": 3.23,
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     "cohort": "tiemersma2002",
     "prov": "CUP 2016 cup2016_tiemersma2002_colorectal"
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   "MCCS (English 2004)": {
    "main": {
     "rr": 1.1882,
     "lo": 0.8888,
     "hi": 1.5666,
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     "cohort": "mccs",
     "prov": "english2004_005 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]"
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    "adjusted for processed meat": {
     "rr": 1.1225,
     "lo": 0.8888,
     "hi": 1.5666,
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     "cohort": "mccs",
     "prov": "english2004_076 [continuous_scaled; per_serving_week x5.833 (portion 120.0 g)]"
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   "EPIC (Papadimitriou 2022)": {
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     "rr": 1.0562272809740614,
     "lo": 0.9457201447694336,
     "hi": 1.144284394932628,
     "label": "papadimitriou2022",
     "cohort": "epic",
     "prov": "papadimitriou2022_001 [^2.762]"
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    "Norat 2005 observed": {
     "rr": 1.21,
     "lo": 1.02,
     "hi": 1.43,
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     "cohort": "epic",
     "prov": "norat2005_031 [continuous_scaled; per_100g]"
    },
    "Norat 2005 calibrated": {
     "rr": 1.49,
     "lo": 0.91,
     "hi": 2.43,
     "label": "norat2005",
     "cohort": "epic",
     "prov": "norat2005_032"
    }
   },
   "SMC (Larsson 2005)": {
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     "rr": 1.2252,
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     "cohort": "smc",
     "prov": "larsson2005_033;larsson2005_034;larsson2005_035;larsson2005_036 [GL_categories; conversion:cup:paper_median]"
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    "total red meat per 100 g (paper)": {
     "rr": 1.2,
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     "cohort": "smc",
     "prov": "larsson2005_085 [continuous_scaled; per_100g]"
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   },
   "MEC (Ollberding 2012)": {
    "main": {
     "rr": 0.9665,
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     "hi": 1.1264,
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     "cohort": "mec",
     "prov": "ollberding2012_066;ollberding2012_067;ollberding2012_068;ollberding2012_069;ollberding2012_070 [GL_categories; conversion:cup:paper_median]"
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    "total red meat (CUP's row)": {
     "rr": 1.01,
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     "cohort": "ollberding2012",
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   "JPHC + Takayama (Islam 2019)": {
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     "hi": 1.3060353962917748,
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     "cohort": "jphc",
     "prov": "islam2019_149 [continuous_scaled; per_100g]; islam2019_274 [continuous_scaled; per_100g] [strata combined, fixed]"
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   },
   "UK Biobank (Knuppel 2020)": {
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     "cohort": "ukbiobank",
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    "Bradbury 2020 (same cohort)": {
     "rr": 1.3871,
     "lo": 0.9939,
     "hi": 1.936,
     "label": "bradbury2020",
     "cohort": "ukbiobank",
     "prov": "bradbury2020_006;bradbury2020_007;bradbury2020_008;bradbury2020_009 [GL_categories; paper_dose_point]"
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   },
   "NIH-AARP (Zouiouich 2025)": {
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     "cohort": "nih_aarp",
     "prov": "zouiouich2025_134"
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    "at 1800 kcal": {
     "rr": 1.1454497672404487,
     "lo": 1.0668850464702246,
     "hi": 1.2245574428122177,
     "label": "zouiouich2025",
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_134 [^1.111]"
    },
    "at 2200 kcal": {
     "rr": 1.117514406159317,
     "lo": 1.0543998417261937,
     "hi": 1.1802743008522547,
     "label": "zouiouich2025",
     "cohort": "nih_aarp",
     "prov": "zouiouich2025_134 [^0.909]"
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   }
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   {
    "key": "DANSDA (Mejborn 2021)",
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   {
    "key": "Israel pooled (Dankner 2024)",
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   {
    "key": "Sister Study (Mehta 2020)",
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    "cohort": "sister"
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   {
    "key": "NHS + HPFS (Bernstein 2015)",
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   {
    "key": "Million Women (Papier 2025)",
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   {
    "key": "Alberta's Tomorrow (Al Rajabi 2021)",
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   {
    "key": "BWHS (Yiannakou 2022)",
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   {
    "key": "Finnish cohorts (Tammi 2024)",
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   {
    "key": "Korea (Wie 2014)",
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   {
    "key": "SWHS (Lee 2009)",
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   "Netherlands MP (Tiemersma 2002) = CUP value": {
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   "MCCS (English 2004) = main": {
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   "MCCS (English 2004) = adjusted for processed meat": {
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   "EPIC (Papadimitriou 2022) = main": {
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   "EPIC (Papadimitriou 2022) = Norat 2005 observed": {
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   "SMC (Larsson 2005) = main": {
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   "SMC (Larsson 2005) = total red meat per 100 g (paper)": {
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   "MEC (Ollberding 2012) = main": {
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   "MEC (Ollberding 2012) = total red meat (CUP's row)": {
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   "JPHC + Takayama (Islam 2019) = main": {
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   "JPHC + Takayama (Islam 2019) = Wada 2017 (Takayama only)": {
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   "UK Biobank (Knuppel 2020) = main": {
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   "UK Biobank (Knuppel 2020) = Bradbury 2020 (same cohort)": {
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   "NIH-AARP (Zouiouich 2025) = main": {
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   "NIH-AARP (Zouiouich 2025) = at 1800 kcal": {
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   "model = random": {
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    "set": "alrajabi2021_m2_colorectal_women_red",
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 "absolute_risk": {
  "assumptions": {
   "baseline_risk_pct_before_80": 6.5,
   "mean_intake_g_day": 89.0,
   "new_cases_2025": 4876,
   "formula": "risk(g) = 6.5 % x RR^((g - 89)/100); per 1,000 = 10 x difference in %; cases/year = 4876 x (1 - 1/RR^((89-50)/100))"
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 }
}