{
 "id": "wcrf2007",
 "title": "WCRF/AICR Second Expert Report 2007 (Fig 4.3.2: red meat 'per time/week', cohort studies — the values are per time/day, see deviations)",
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     "lo": 1.02,
     "hi": 1.43,
     "w": 73.48323261646706,
     "note": "model: observed estimate"
    },
    {
     "label": "larsson2005",
     "cohort": "smc",
     "rr": 1.2252,
     "lo": 0.8978,
     "hi": 1.6721,
     "w": 21.69039453060665,
     "note": "exposure: unprocessed red meat as main dish, GL with 120 g/serving (R105)"
    }
   ],
   "loo": {
    "pietinen1999": [
     1.2134474560528639,
     1.0460520308837942,
     1.4076304859875004
    ],
    "norat2005": [
     1.13306311980827,
     0.8364710909879975,
     1.5348193706888922
    ],
    "larsson2005": [
     1.1575809973954871,
     0.9139976248829654,
     1.4660801396532215
    ]
   }
  }
 ],
 "deviations": [
  {
   "study": "english2004",
   "class": "transcription",
   "text": "Fig 4.3.2 is labelled 'per time/week', but English 2004 prints 1.03 (0.98–1.08) per serving/week and the figure's 1.23 (0.88–1.73) equals 1.03^7 = 1.23 (0.87–1.71); SLR 2010 calls the same analysis 'per time/day' (p156, Table 36). The increment is per time/day; Willett's 1.81 and Giovannucci's 2.20 are likewise implausible as weekly slopes",
   "page": "SER Fig 4.3.2 p121; SLR 2010 p156–157; English 2004 Table 3",
   "alternative": null,
   "alt_note": "",
   "outcome": "colorectal/colon"
  },
  {
   "study": "chen1998_rapid",
   "class": "duplicate",
   "text": "Chen 1998 entered twice, split by NAT2 genotype (rapid / slow acetylators); one study",
   "page": "Fig 4.3.2",
   "alternative": [
    1.1361221508551176,
    0.6281276538282716,
    2.0549541702180054
   ],
   "alt_note": "NAT2 strata combined (fixed)",
   "outcome": "colorectal/colon"
  },
  {
   "study": "chen1998_slow",
   "class": "duplicate",
   "text": "see rapid row",
   "page": "Fig 4.3.2",
   "alternative": "remove",
   "alt_note": "",
   "outcome": "colorectal/colon"
  },
  {
   "study": "chen1998_rapid",
   "class": "inclusion",
   "text": "Physicians' Health Study nested case-control",
   "page": "Chen 1998",
   "alternative": null,
   "alt_note": "",
   "outcome": "colorectal/colon"
  },
  {
   "study": "willett1990",
   "class": "inclusion",
   "text": "NHS 1980–86 (150 colon cases); the report cites Wei 2004 (NHS+HPFS to 2000, 1,139 colon + 339 rectal cases, ref 19) but used it only in the HvL plot. Wei's continuous estimate cannot substitute: its printed unit (per week) contradicts the paper's Methods (per day) and the row is 'disputed' (rettelogg R15)",
   "page": "SER refs 9, 19; SLR 2010 Table 37",
   "alternative": "remove",
   "alt_note": "superseded cohort; no usable continuous row in Wei 2004",
   "outcome": "colorectal/colon"
  },
  {
   "study": "giovannucci1994",
   "class": "inclusion",
   "text": "HPFS 1986–92 (205 colon cases); superseded by Wei 2004 (same cohort), which the report cites",
   "page": "SER refs 10, 19",
   "alternative": "remove",
   "alt_note": "superseded cohort",
   "outcome": "colorectal/colon"
  },
  {
   "study": "singh1998",
   "class": "dose",
   "text": "4.51 (0.38–53.27) per time/week from a never / <1 / ≥1 time per week scale; the top category is open (≥1/week)",
   "page": "Singh 1998 Table 3",
   "alternative": null,
   "alt_note": "",
   "outcome": "colorectal/colon"
  },
  {
   "study": "bostick1994",
   "class": "transcription",
   "text": "0.96 (0.80–1.14) per time/week has a CI four to five times narrower (log width 0.35) than a GL slope from Bostick's four categories, three above the reference (212 cases) can give (0.94; 0.43–2.04 per 100 g); cannot be checked without the 2005 SLR (called the 2006 SLR in the protocol)",
   "page": "Fig 4.3.2; Bostick 1994 Table 3",
   "alternative": null,
   "alt_note": "",
   "outcome": "colorectal/colon"
  },
  {
   "study": "pietinen1999",
   "class": "exposure",
   "text": "Fig 4.3.3's 1.05 (0.74–1.48) is ATBC red meat including processed meat (Pietinen 1999 Table 5, multivariate): GL from those categories gives 1.05 (0.74–1.49). The paper's red meat row without processed meat (beef, pork, lamb; the row CUP 2010 and 2016 used) gives 0.83 (0.43–1.61)",
   "page": "SER Fig 4.3.3 p121; Pietinen 1999 Table 5; derived_per100g.csv",
   "alternative": [
    0.8338,
    0.4313,
    1.6119
   ],
   "alt_note": "unprocessed red meat, GL (R105)",
   "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"
  },
  {
   "study": "larsson2005",
   "class": "exposure",
   "text": "Fig 4.3.3's 1.43 (1.05–[0.95]) is SMC total red meat including processed meat (bacon, sausage, ham/cold cuts, blood pudding): GL from those categories gives 1.43 (1.05–1.95), which also confirms that the misprinted upper limit should be about 1.95. The paper's unprocessed 'red meat as main dish' row with CUP's 120 g/serving gives 1.23 (0.90–1.67)",
   "page": "SER Fig 4.3.3 p121; Larsson 2005 Table I; derived_per100g.csv",
   "alternative": [
    1.2252,
    0.8978,
    1.6721
   ],
   "alt_note": "unprocessed red meat as main dish, GL with 120 g/serving (R105)",
   "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"
  },
  {
   "study": "norat2005",
   "class": "model",
   "text": "Norat's 1.49 (0.91–2.43) is EPIC's measurement-error-calibrated estimate for fresh red meat; the observed estimate is 1.21 (1.02–1.43) (the value CUP 2010/2016 used). Shown as a model choice, not corrected",
   "page": "SER Fig 4.3.3; Norat 2005 Table 4",
   "alternative": [
    1.21,
    1.02,
    1.43
   ],
   "alt_note": "observed estimate",
   "outcome": "colorectal (Fig 4.3.3, per 100 g/day)"
  }
 ],
 "notes": [
  "R105 (2.11.2026): Fig 4.3.3's Pietinen and Larsson values are reproduced within rounding from the papers' total red meat rows (incl. processed; Pietinen's upper limit 1.49 vs printed 1.48): 1.0523 and 1.4326 (1.054–1.947). Not registered as deviations before K27a.",
  "Fig 4.3.3 (per 100 g/day, 3 studies): Larsson 2005 is printed '1.43 (1.05–0.95)' in the report itself (PDF excerpt supplied by the author). Reading the upper limit off the forest plot (≈1.94) reproduces the figure's summary as a fixed-effect pool and the text's as random effects; SLR 2010 Table 36's 1.29 (0.94–1.78) remains unexplained. Norat's 1.49 is EPIC's *calibrated* estimate. The HvL plot (Fig 4.3.1) has no summary; Fig 4.3.4 is a line graph without values. The 2006 SLR is not on disk; per-study weights and case numbers are not printed."
 ]
}