meta_check.py on /home/claude/db/database/synthesis_extraction.csv (171 data rows) ==================================================================================================== PART A - naive groups: synth_id x outcome x analysis x increment (all rows with rr+ci) NB: these groups mix analyses the table does not distinguish (see K11 report). norat2002 | colorectal | hvl | hvl n_rows=8 k=7 RE 1.24 (1.01-1.51) FE 1.24 (1.01-1.51) Q=5.16 df=6 I2=0.0% tau2=0.0000 norat2002 | colon | hvl | hvl n_rows=9 k=4 RE 1.34 (1.04-1.73) FE 1.27 (1.08-1.49) Q=5.61 df=3 I2=46.5% tau2=0.0317 norat2002 | colon | dose_response | per_5g n_rows=1 k=1 RE 0.98 (0.93-1.03) FE 0.98 (0.93-1.03) Q=0.00 df=0 I2=0.0% tau2=0.0000 larsson2006 | colon | hvl | hvl n_rows=10 k=10 RE 1.23 (1.07-1.41) FE 1.23 (1.07-1.41) Q=2.75 df=9 I2=0.0% tau2=0.0000 larsson2006 | colorectal | hvl | hvl n_rows=13 k=13 RE 1.29 (1.15-1.44) FE 1.29 (1.15-1.44) Q=4.07 df=12 I2=0.0% tau2=0.0000 larsson2006 | rectum | hvl | hvl n_rows=7 k=7 RE 1.56 (1.25-1.95) FE 1.56 (1.25-1.95) Q=4.81 df=6 I2=0.0% tau2=0.0000 larsson2006 | proximal_colon | hvl | hvl n_rows=3 k=3 RE 1.15 (0.91-1.47) FE 1.15 (0.91-1.47) Q=0.72 df=2 I2=0.0% tau2=0.0000 larsson2006 | distal_colon | hvl | hvl n_rows=3 k=3 RE 1.31 (0.62-2.79) FE 1.18 (0.88-1.58) Q=12.36 df=2 I2=83.8% tau2=0.3673 larsson2006 | colorectal | dose_response | per_120g n_rows=12 (no usable rr/ci) larsson2006 | colon | dose_response | per_120g n_rows=2 (no usable rr/ci) wcrf2007 | colon | hvl | hvl n_rows=5 k=5 RE 1.59 (1.22-2.06) FE 1.59 (1.26-2.00) Q=5.08 df=4 I2=21.2% tau2=0.0192 wcrf2007 | colorectal | hvl | hvl n_rows=8 k=8 RE 1.26 (1.08-1.46) FE 1.26 (1.08-1.46) Q=4.37 df=7 I2=0.0% tau2=0.0000 wcrf2007 | colon | dose_response | per_time_week n_rows=4 k=4 RE 1.57 (0.91-2.72) FE 1.12 (0.95-1.31) Q=14.09 df=3 I2=78.7% tau2=0.2031 wcrf2007 | colorectal | dose_response | per_time_week n_rows=7 k=5 RE 1.28 (0.92-1.79) FE 1.26 (0.95-1.68) Q=4.36 df=4 I2=8.2% tau2=0.0162 wcrf2007 | colorectal | dose_response | per_100g n_rows=3 k=2 RE 1.20 (0.86-1.67) FE 1.18 (0.89-1.57) Q=1.30 df=1 I2=23.2% tau2=0.0142 cup2010 | colorectal | dose_response | per_100g n_rows=10 k=10 RE 1.18 (1.06-1.32) FE 1.18 (1.06-1.32) Q=8.35 df=9 I2=0.0% tau2=0.0000 cup2010 | colon | dose_response | per_100g n_rows=21 k=21 RE 1.14 (1.04-1.26) FE 1.14 (1.04-1.26) Q=12.25 df=20 I2=0.0% tau2=0.0000 cup2010 | rectum | dose_response | per_100g n_rows=7 k=7 RE 1.18 (0.98-1.43) FE 1.18 (0.98-1.43) Q=4.09 df=6 I2=0.0% tau2=0.0000 cup2010 | colorectal | hvl | hvl n_rows=12 k=12 RE 1.10 (1.00-1.21) FE 1.10 (1.02-1.19) Q=14.18 df=11 I2=22.4% tau2=0.0059 cup2010 | colon | hvl | hvl n_rows=12 k=12 RE 1.18 (1.04-1.35) FE 1.18 (1.04-1.35) Q=10.69 df=11 I2=0.0% tau2=0.0000 cup2010 | rectum | hvl | hvl n_rows=7 k=7 RE 1.14 (0.83-1.56) FE 1.13 (0.90-1.42) Q=9.69 df=6 I2=38.1% tau2=0.0638 cup2010 | colorectal | dose_response | per_time_week n_rows=1 k=1 RE 1.03 (0.98-1.08) FE 1.03 (0.98-1.08) Q=0.00 df=0 I2=100.0% tau2=0.0000 cup2010 | colon | dose_response | per_time_week n_rows=1 k=1 RE 1.00 (0.94-1.07) FE 1.00 (0.94-1.07) Q=0.00 df=0 I2=0.0% tau2=0.0000 cup2010 | rectum | dose_response | per_time_week n_rows=1 k=1 RE 1.08 (1.00-1.17) FE 1.08 (1.00-1.17) Q=0.00 df=0 I2=0.0% tau2=0.0000 cup2010 | proximal_colon | hvl | hvl n_rows=2 k=2 RE 1.20 (0.93-1.54) FE 1.20 (0.93-1.54) Q=0.30 df=1 I2=0.0% tau2=0.0000 cup2010 | distal_colon | hvl | hvl n_rows=2 k=2 RE 1.18 (0.43-3.25) FE 1.13 (0.83-1.53) Q=10.80 df=1 I2=90.7% tau2=0.4819 ==================================================================================================== PART B - published analyses re-pooled from explicitly selected rows ---------------------------------------------------------------------------------------------------- Norat 2002 Table I / Fig 2 - red meat HvL, cohort (9 studies; Thun has no CI -> 8 pooled) published : 1.27 (1.11-1.45), n=9, p-het 0.45 recomputed: k=8 RE 1.38 (1.16-1.64) FE 1.38 (1.16-1.64) Q=5.40 df=7 I2=0.0% tau2=0.0000 L6 willett1990 colon RE wt 13.19% L7 giovannucci1994 colon RE wt 19.64% L10 bostick1994 colon RE wt 11.44% L13 kato1997 colorectal RE wt 8.89% L14 chen1998 colorectal RE wt 10.50% L15 hsing1998 colorectal RE wt 5.09% L16 singh1998 colorectal RE wt 15.43% L18 pietinen1999 colorectal RE wt 15.82% ---------------------------------------------------------------------------------------------------- Norat 2002 sensitivity: + Thun 1992 as read off Fig 2 (approx 1.14 (0.93-1.39), digitised by K11 from norat_p-05.png pixels) published : 1.27 (1.11-1.45) recomputed: k=9 RE 1.27 (1.11-1.45) FE 1.27 (1.11-1.45) Q=7.34 df=8 I2=0.0% tau2=0.0000 L6 willett1990 colon RE wt 7.45% L7 giovannucci1994 colon RE wt 11.09% L10 bostick1994 colon RE wt 6.46% L13 kato1997 colorectal RE wt 5.02% L14 chen1998 colorectal RE wt 5.93% L15 hsing1998 colorectal RE wt 2.87% L16 singh1998 colorectal RE wt 8.71% L18 pietinen1999 colorectal RE wt 8.93% Thun 1992 digitised RE wt 43.53% ---------------------------------------------------------------------------------------------------- Norat 2002 sensitivity: + Thun digitised, Singh as plotted in Fig 2 (approx 1.50 (0.95-2.36), digitised) published : 1.27 (1.11-1.45) recomputed: k=9 RE 1.28 (1.12-1.46) FE 1.28 (1.12-1.46) Q=7.64 df=8 I2=0.0% tau2=0.0000 L6 willett1990 colon RE wt 7.46% L7 giovannucci1994 colon RE wt 11.11% L10 bostick1994 colon RE wt 6.47% L13 kato1997 colorectal RE wt 5.03% L14 chen1998 colorectal RE wt 5.94% L15 hsing1998 colorectal RE wt 2.88% L18 pietinen1999 colorectal RE wt 8.95% L16 singh1998 colorectal RE wt 8.51% Thun 1992 digitised RE wt 43.63% ---------------------------------------------------------------------------------------------------- Larsson 2006 Fig 1 / text p2660 - red meat HvL CRC (15 studies) published : 1.28 (1.15-1.42), Q=4.86, p=0.99, I2=0% recomputed: k=15 RE 1.28 (1.15-1.42) FE 1.28 (1.15-1.42) Q=4.86 df=14 I2=0.0% tau2=0.0000 L19 bostick1994 colon RE wt 4.08% L20 kato1997 colorectal RE wt 3.17% L21 chen1998 colorectal RE wt 3.74% L22 hsing1998 colorectal RE wt 1.81% L24 singh1998 colon RE wt 5.50% L25 pietinen1999 colorectal RE wt 5.64% L26 jarvinen2001 colorectal RE wt 2.47% L29 tiemersma2002 colorectal RE wt 3.24% L30 flood2003 colorectal RE wt 14.26% L31 wei2004 colorectal RE wt 4.13% L34 wei2004 colorectal RE wt 5.23% L37 english2004 colorectal RE wt 10.77% L40 larsson2005 colorectal RE wt 18.55% L45 chao2005 colorectal RE wt 7.57% L50 norat2005 colorectal RE wt 9.83% ---------------------------------------------------------------------------------------------------- Larsson 2006 Table II colon - all 10 colon rows in Table I published : 1.21 (1.05-1.40), n=9, Q=2.35 recomputed: k=10 RE 1.23 (1.07-1.41) FE 1.23 (1.07-1.41) Q=2.75 df=9 I2=0.0% tau2=0.0000 L19 bostick1994 colon RE wt 7.02% L23 hsing1998 colon RE wt 2.63% L24 singh1998 colon RE wt 9.47% L27 jarvinen2001 colon RE wt 2.61% L32 wei2004 colon RE wt 5.55% L35 wei2004 colon RE wt 7.02% L38 english2004 colon RE wt 11.18% L41 larsson2005 colon RE wt 10.49% L46 chao2005 colon RE wt 32.65% L51 norat2005 colon RE wt 11.38% leave out L19 bostick1994 -> k=9 RE 1.24 (1.08-1.43) FE 1.24 (1.08-1.43) Q=2.34 df=8 I2=0.0% tau2=0.0000 leave out L23 hsing1998 -> k=9 RE 1.21 (1.06-1.40) FE 1.21 (1.06-1.40) Q=1.95 df=8 I2=0.0% tau2=0.0000 leave out L24 singh1998 -> k=9 RE 1.21 (1.05-1.40) FE 1.21 (1.05-1.40) Q=2.35 df=8 I2=0.0% tau2=0.0000 leave out L27 jarvinen2001 -> k=9 RE 1.22 (1.06-1.41) FE 1.22 (1.06-1.41) Q=2.71 df=8 I2=0.0% tau2=0.0000 leave out L32 wei2004 -> k=9 RE 1.22 (1.06-1.41) FE 1.22 (1.06-1.41) Q=2.70 df=8 I2=0.0% tau2=0.0000 leave out L35 wei2004 -> k=9 RE 1.22 (1.06-1.41) FE 1.22 (1.06-1.41) Q=2.61 df=8 I2=0.0% tau2=0.0000 leave out L38 english2004 -> k=9 RE 1.24 (1.07-1.44) FE 1.24 (1.07-1.44) Q=2.45 df=8 I2=0.0% tau2=0.0000 leave out L41 larsson2005 -> k=9 RE 1.21 (1.04-1.40) FE 1.21 (1.04-1.40) Q=2.30 df=8 I2=0.0% tau2=0.0000 leave out L46 chao2005 -> k=9 RE 1.27 (1.07-1.50) FE 1.27 (1.07-1.50) Q=2.34 df=8 I2=0.0% tau2=0.0000 leave out L51 norat2005 -> k=9 RE 1.23 (1.07-1.43) FE 1.23 (1.07-1.43) Q=2.69 df=8 I2=0.0% tau2=0.0000 ---------------------------------------------------------------------------------------------------- Larsson 2006 Table II rectum (7 studies) published : 1.56 (1.25-1.95), Q=4.82, I2=0% recomputed: k=7 RE 1.56 (1.25-1.95) FE 1.56 (1.25-1.95) Q=4.81 df=6 I2=0.0% tau2=0.0000 L28 jarvinen2001 rectum RE wt 4.05% L33 wei2004 rectum RE wt 4.25% L36 wei2004 rectum RE wt 5.12% L39 english2004 rectum RE wt 12.72% L44 larsson2005 rectum RE wt 26.40% L49 chao2005 rectum RE wt 32.42% L54 norat2005 rectum RE wt 15.05% ---------------------------------------------------------------------------------------------------- Larsson 2006 Table II proximal colon (3) published : 1.15 (0.91-1.47), Q=0.72 recomputed: k=3 RE 1.15 (0.91-1.47) FE 1.15 (0.91-1.47) Q=0.72 df=2 I2=0.0% tau2=0.0000 L42 larsson2005 proximal_colon RE wt 30.82% L47 chao2005 proximal_colon RE wt 53.67% L52 norat2005 proximal_colon RE wt 15.51% ---------------------------------------------------------------------------------------------------- Larsson 2006 Table II distal colon (3) published : 1.31 (0.62-2.79), Q=12.36, I2=83.8% recomputed: k=3 RE 1.31 (0.62-2.79) FE 1.18 (0.88-1.58) Q=12.36 df=2 I2=83.8% tau2=0.3673 L43 larsson2005 distal_colon RE wt 34.04% L48 chao2005 distal_colon RE wt 35.90% L53 norat2005 distal_colon RE wt 30.06% ---------------------------------------------------------------------------------------------------- WCRF 2007 Fig 4.3.2 - per time/week (9 lines, 7 studies) published : 1.43 (1.05-1.94); I2=58% p=0.01 (CUP 2010 Table 36) recomputed: k=9 RE 1.43 (1.05-1.94) FE 1.15 (1.00-1.32) Q=19.00 df=8 I2=57.9% tau2=0.0918 L82 willett1990 colon RE wt 17.26% L83 bostick1994 colon RE wt 24.41% L84 giovannucci1994 colon RE wt 13.73% L85 singh1998 colon RE wt 1.45% L86 chen1998 colorectal RE wt 5.13% L87 chen1998 colorectal RE wt 11.52% L88 tiemersma2002 colorectal RE wt 3.96% L89 tiemersma2002 colorectal RE wt 2.47% L90 english2004 colorectal RE wt 20.07% ---------------------------------------------------------------------------------------------------- WCRF 2007 Fig 4.3.3 - per 100 g/day (Larsson CI printed 1.05-0.95 -> not usable) published : 1.29 (1.05-1.59) fig / 1.29 (1.04-1.60) text / 1.29 (0.94-1.78) CUP T36; I2=32% recomputed: k=2 RE 1.20 (0.86-1.67) FE 1.18 (0.89-1.57) Q=1.30 df=1 I2=23.2% tau2=0.0142 L91 pietinen1999 colorectal RE wt 62.86% L92 norat2005 colorectal RE wt 37.14% (no usable CI, not pooled: L93 larsson2005 colorectal) ---------------------------------------------------------------------------------------------------- WCRF 2007 Fig 4.3.3 sensitivity - Larsson upper CI imputed symmetric on log scale (1.43^2/1.05=1.95) published : 1.29 (1.05-1.59) recomputed: k=3 RE 1.29 (1.04-1.60) FE 1.29 (1.05-1.59) Q=2.11 df=2 I2=5.4% tau2=0.0020 L91 pietinen1999 colorectal RE wt 36.32% L92 norat2005 colorectal RE wt 18.67% L93 larsson2005 colorectal RE wt 45.01% ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 70 (= Chan Fig 4 CRC) - DR per 100 g/day CRC published : 1.17 (1.05-1.31), I2=0%, p=0.483 recomputed: k=8 RE 1.17 (1.05-1.31) FE 1.17 (1.05-1.31) Q=6.59 df=7 I2=0.0% tau2=0.0000 L96 lee2009 colorectal RE wt 6.85% printed 6.78% diff +0.07 L97 nothlings2009 colorectal RE wt 6.30% printed 6.25% diff +0.05 L98 larsson2005 colorectal RE wt 13.28% printed 13.11% diff +0.17 L99 norat2005 colorectal RE wt 44.45% printed 44.43% diff +0.02 L100 english2004 colorectal RE wt 15.40% printed 15.79% diff -0.39 L101 tiemersma2002 colorectal RE wt 3.00% printed 2.98% diff +0.02 L102 jarvinen2001 colorectal RE wt 7.81% printed 7.74% diff +0.07 L103 pietinen1999 colorectal RE wt 2.91% printed 2.92% diff -0.01 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 71 female subtotal (Lee, Larsson from Fig 70 rows; Tiemersma F) published : 1.05 (0.78-1.42), I2=21.9%; printed wts Lee 35.70, Larsson 55.60, Tiemersma 8.71 recomputed: k=3 RE 1.05 (0.78-1.43) FE 1.07 (0.84-1.37) Q=2.62 df=2 I2=23.6% tau2=0.0187 L96 lee2009 colorectal RE wt 35.96% printed 35.70% diff +0.26 L98 larsson2005 colorectal RE wt 55.24% printed 55.60% diff -0.36 L104 tiemersma2002 colorectal RE wt 8.80% printed 8.71% diff +0.09 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 71 male subtotal (Tiemersma M; Pietinen from Fig 70 row) published : 1.28 (0.49-3.35), I2=64.3%; printed wts Tiemersma 43.79, Pietinen 56.21 recomputed: k=2 RE 1.28 (0.49-3.35) FE 1.15 (0.67-1.97) Q=2.82 df=1 I2=64.5% tau2=0.3152 L105 tiemersma2002 colorectal RE wt 43.88% printed 43.79% diff +0.09 L103 pietinen1999 colorectal RE wt 56.12% printed 56.21% diff -0.09 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 74 - DR per 100 g/day colon published : 1.12 (0.97-1.29), I2=0%, p=0.888 recomputed: k=9 RE 1.12 (0.97-1.29) FE 1.12 (0.97-1.29) Q=3.66 df=8 I2=0.0% tau2=0.0000 L106 lee2009 colon RE wt 4.91% printed 4.94% diff -0.03 L107 oba2006 colon RE wt 2.11% printed 2.13% diff -0.02 L108 norat2005 colon RE wt 42.55% printed 42.51% diff +0.04 L109 english2004 colon RE wt 14.19% printed 13.95% diff +0.24 L110 wei2004 colon RE wt 15.39% printed 15.55% diff -0.16 L111 wei2004 colon RE wt 9.44% printed 9.45% diff -0.01 L112 jarvinen2001 colon RE wt 7.43% printed 7.47% diff -0.04 L113 singh1998 colon RE wt 0.70% printed 0.70% diff +0.00 L114 bostick1994 colon RE wt 3.29% printed 3.29% diff -0.00 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 75 female subtotal published : 1.00 (0.72-1.38); printed wts Lee 26.64, Oba 4.66, Wei 50.94, Bostick 17.76 recomputed: k=4 RE 1.00 (0.72-1.38) FE 1.00 (0.72-1.38) Q=1.89 df=3 I2=0.0% tau2=0.0000 L106 lee2009 colon RE wt 26.51% printed 26.64% diff -0.13 L115 oba2006 colon RE wt 4.71% printed 4.66% diff +0.05 L111 wei2004 colon RE wt 51.01% printed 50.94% diff +0.07 L114 bostick1994 colon RE wt 17.77% printed 17.76% diff +0.01 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 75 male subtotal published : 1.06 (0.75-1.50); printed wts Oba 7.54, Wei 92.46 recomputed: k=2 RE 1.07 (0.76-1.51) FE 1.07 (0.76-1.51) Q=0.00 df=1 I2=0.0% tau2=0.0000 L116 oba2006 colon RE wt 7.65% printed 7.54% diff +0.11 L110 wei2004 colon RE wt 92.35% printed 92.46% diff -0.11 ---------------------------------------------------------------------------------------------------- Chan 2011 Fig 4 - DR per 100 g/day colon (10 rows incl. Larsson 2005) published : 1.17 (1.02-1.33), I2=0%, p=0.646 recomputed: k=10 RE 1.17 (1.02-1.34) FE 1.17 (1.02-1.34) Q=6.93 df=9 I2=0.0% tau2=0.0000 L155 larsson2005 colon RE wt 10.33% printed 10.33% diff +0.00 L156 bostick1994 colon RE wt 2.95% printed 2.95% diff -0.00 L157 singh1998 colon RE wt 0.63% printed 0.63% diff -0.00 L158 jarvinen2001 colon RE wt 6.66% printed 6.70% diff -0.04 L159 english2004 colon RE wt 12.73% printed 12.51% diff +0.22 L160 wei2004 colon RE wt 8.47% printed 8.47% diff -0.00 L161 wei2004 colon RE wt 13.80% printed 13.95% diff -0.15 L162 norat2005 colon RE wt 38.15% printed 38.12% diff +0.03 L163 oba2006 colon RE wt 1.89% printed 1.91% diff -0.02 L164 lee2009 colon RE wt 4.40% printed 4.43% diff -0.03 ---------------------------------------------------------------------------------------------------- CUP 2010 SLR Fig 78 (= Chan Fig 4 rectal) - DR per 100 g/day rectum published : 1.18 (0.98-1.42), I2=0%, p=0.666 recomputed: k=7 RE 1.18 (0.98-1.43) FE 1.18 (0.98-1.43) Q=4.09 df=6 I2=0.0% tau2=0.0000 L117 lee2009 rectum RE wt 5.36% printed 5.34% diff +0.02 L118 larsson2005 rectum RE wt 10.75% printed 10.87% diff -0.12 L119 norat2005 rectum RE wt 47.17% printed 47.17% diff +0.00 L120 english2004 rectum RE wt 16.43% printed 16.35% diff +0.08 L121 wei2004 rectum RE wt 7.22% printed 7.30% diff -0.08 L122 wei2004 rectum RE wt 4.80% printed 4.72% diff +0.08 L123 jarvinen2001 rectum RE wt 8.28% printed 8.24% diff +0.04 ---------------------------------------------------------------------------------------------------- Chan 2011 Table 1 - HvL CRC (= SLR Fig 73, 12 studies) published : 1.10 (1.00-1.21), I2=22%, p=0.22 recomputed: k=12 RE 1.10 (1.00-1.21) FE 1.10 (1.02-1.19) Q=14.18 df=11 I2=22.4% tau2=0.0059 L124 cross2010 colorectal RE wt 21.08% L125 lee2009 colorectal RE wt 7.84% L126 nothlings2009 colorectal RE wt 10.29% L127 butler2008 colorectal RE wt 13.05% L128 chan2005 colorectal RE wt 6.11% L129 larsson2005 colorectal RE wt 12.42% L130 norat2005 colorectal RE wt 11.11% L131 english2004 colorectal RE wt 7.14% L132 tiemersma2002 colorectal RE wt 2.46% L133 jarvinen2001 colorectal RE wt 1.90% L134 pietinen1999 colorectal RE wt 4.19% L135 kato1997 colorectal RE wt 2.41% ---------------------------------------------------------------------------------------------------- Chan 2011 Table 1 - HvL colon (SLR Fig 77, all 12 lines entered separately) published : 1.18 (1.04-1.35), n=10, I2=0%, p=0.70 recomputed: k=12 RE 1.18 (1.04-1.35) FE 1.18 (1.04-1.35) Q=10.69 df=11 I2=0.0% tau2=0.0000 L136 lee2009 colon RE wt 8.12% L137 oba2006 colon RE wt 7.50% L138 oba2006 colon RE wt 7.39% L139 larsson2005 colon RE wt 8.18% L140 larsson2005 colon RE wt 10.76% L141 norat2005 colon RE wt 18.68% L142 english2004 colon RE wt 9.98% L143 wei2004 colon RE wt 4.95% L144 wei2004 colon RE wt 6.27% L145 jarvinen2001 colon RE wt 2.33% L146 singh1998 colon RE wt 8.45% L147 bostick1994 colon RE wt 7.39% ---------------------------------------------------------------------------------------------------- Chan 2011 HvL colon - Oba M+F and Larsson prox+dist combined (FE) within study -> 10 studies published : 1.18 (1.04-1.35), n=10, I2=0% recomputed: k=10 RE 1.18 (1.04-1.35) FE 1.18 (1.04-1.35) Q=6.42 df=9 I2=0.0% tau2=0.0000 L136 lee2009 colon RE wt 8.12% L141 norat2005 colon RE wt 18.68% L142 english2004 colon RE wt 9.98% L143 wei2004 colon RE wt 4.95% L144 wei2004 colon RE wt 6.27% L145 jarvinen2001 colon RE wt 2.33% L146 singh1998 colon RE wt 8.45% L147 bostick1994 colon RE wt 7.39% Oba 2006 M+F FE 0.90 (0.64-1.27) RE wt 14.90% Larsson 2005 prox+dist FE 1.42 (1.05-1.92) RE wt 18.94% ---------------------------------------------------------------------------------------------------- Chan 2011 Table 1 - HvL rectum (= SLR Fig 81, 7 lines) published : 1.14 (0.83-1.56), I2=38%, p=0.14 recomputed: k=7 RE 1.14 (0.83-1.56) FE 1.13 (0.90-1.42) Q=9.69 df=6 I2=38.1% tau2=0.0638 L148 lee2009 rectum RE wt 14.86% L149 larsson2005 rectum RE wt 24.20% L150 norat2005 rectum RE wt 23.57% L151 english2004 rectum RE wt 15.55% L152 wei2004 rectum RE wt 6.98% L153 wei2004 rectum RE wt 8.12% L154 jarvinen2001 rectum RE wt 6.71% ---------------------------------------------------------------------------------------------------- Chan 2011 Table 1 - HvL proximal colon (Larsson 2005 + Chao 2005) published : 1.13 (0.83-1.54), n=2, I2=0%, p=0.83 recomputed: k=2 RE 1.20 (0.93-1.54) FE 1.20 (0.93-1.54) Q=0.30 df=1 I2=0.0% tau2=0.0000 L168 larsson2005 proximal_colon RE wt 40.72% L170 chao2005 proximal_colon RE wt 59.28% ---------------------------------------------------------------------------------------------------- Chan 2011 Table 1 - HvL distal colon (Larsson 2005 + Chao 2005) published : 1.57 (0.98-2.49), n=2, I2=53%, p=0.15 recomputed: k=2 RE 1.18 (0.43-3.25) FE 1.13 (0.83-1.53) Q=10.80 df=1 I2=90.7% tau2=0.4819 L169 larsson2005 distal_colon RE wt 49.52% L171 chao2005 distal_colon RE wt 50.48% NB: no pair of Larsson/Chao/Norat proximal or distal values available in the sources reproduces Chan T1; Larsson+Norat distal = 1.83 (1.25-2.68), Larsson+Chao = 1.18 (0.43-3.25). Unresolved (see report).